Patient Oriented Research and Mentoring Program in Orthopedics

以患者为中心的骨科研究和指导计划

• 批准号: 8997060
• 负责人: Elena Losina
• 金额: $ 18.42万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8997060
• 关键词: Address; Age; Age-Years; Aging; Area; Award; Awareness; Behavioral; Behavioral Sciences; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Coupled; Degenerative polyarthritis; Dependency; Diagnosis; Disease; Effectiveness; Elderly; Ensure; Epidemic; Epidemiologist; Evaluation; Evidence based practice; Faculty; Funding; Goals; Grant; Health; Human; Implant; Intervention; Knee Osteoarthritis; Lead; Life; Longevity; Measures; Mentors; Methodology; Midcareer Investigator Award in Patient-Oriented Research; Moderate Exercise; Musculoskeletal; Musculoskeletal Diseases; Nursing Students; Obesity; Occupational Exposure; Occupational injury; Online Systems; Operative Surgical Procedures; Orthopedics; Outcomes Research; Pain; Paper; Patients; Persons; Physical activity; Prevention; Preventive Intervention; Publishing; Quality of life; Randomized Clinical Trials; Readiness; Research; Research Personnel; Research Training; Risk; Risk Factors; Scientist; Source; Structure; Therapeutic Intervention; Time; Training; Training Programs; Work; age group; base; career; clinical care; cohort; design; disability; doctoral student; emerging adult; evidence base; functional disability; innovation; insight; interest; knee replacement arthroplasty; modifiable risk; next generation; patient expectation; patient oriented research; prevent; programs; randomized trial; research study; shared decision making; success; tool; willingness; young adult

DESCRIPTION (provided by applicant): Musculoskeletal (MSK) disorders and particularly osteoarthritis (OA) are a major source of pain, functional impairment, and worsening quality of life across all age groups. Total knee replacement (TKR) is a costly, frequent intervention for knee OA. Its success is generally measured on the basis of implant longevity and pain relief. However, compelling evidence that moderate physical activity enhances overall health indicates that the value of TKR could be increased substantially if TKR recipients engaged in adequate levels of physical activity after rehabilitating from their surgeries. The evidence base in MSK and orthopedic clinical science has substantial gaps. I have devoted the last 15 years to addressing these research needs by designing rigorous patient-oriented research studies and mentoring younger clinical scientists. Through the next K24 cycle, I hope to continue to train young scientists in rigorous studies of MSK and orthopedic problems. In this competitive renewal application, I request five years of funding to enlarge and strengthen the mentoring and research programs. Aim I: To further strengthen my research training program, which focuses on preparing young investigators for rigorous patient-oriented research on MSK and orthopedic disorders. Aim II: To further develop a comprehensive patient-oriented research program in MSK and orthopedic disorders. I highlight two research studies in this proposal: Study 1: Portraying physical activity (PA) over 5 years among recipients of total knee replacement (TKR). Aim 1.1: To follow an established cohort of TKR recipients over 5 years to document long-term trajectories of engagement in PA. Aim 1.2: To determine risk factors for low or declining engagement in PA over 5 years post-TKR. Study 2: Raising awareness of knee OA and willingness to undertake behavioral changes to reduce the risk of knee OA. Aim 2.1. To develop an individualized web-based knee OA risk calculator that incorporates demographic and clinical factors to predict 5, 10, 15, 20, 25, 30-year and life time risk of symptomatic knee OA. Aim 2.2. To conduct a proof of concept randomized trial to establish whether the use of a knee OA risk calculator results in greater readiness for behavioral changes to reduce the risk of knee OA.

描述（由申请人提供）：肌肉骨骼（MSK）疾病，特别是骨关节炎（OA）是所有年龄组疼痛、功能损害和生活质量恶化的主要来源。全膝关节置换术（TKR）是一种昂贵且频繁的膝关节OA治疗方法。其成功与否通常是根据种植体寿命和疼痛缓解程度来衡量的。然而，有令人信服的证据表明，适度的身体活动可以增强整体健康，如果接受TKR的人在手术康复后进行适当的身体活动，TKR的价值就可以大大增加。证据基础在MSK和