Neurodynamics of Compound Threat Cue Perception

复合威胁线索感知的神经动力学

• 批准号: 9054169
• 负责人: KESTUTIS KVERAGA
• 金额: $ 71.92万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9054169
• 关键词: Address; Affective; Amygdaloid structure; Anger; Anterior; Anxiety; Anxiety Disorders; Appearance; Attention; Autistic Disorder; Awareness; Borderline Personality Disorder; Brain; Brain region; Conscious; Cues; Discipline; Disease; Early Diagnosis; Emotional; Emotions; Eye; Face; Face Processing; Facial Expression; Fright; Functional Magnetic Resonance Imaging; Future; Gender; Goals; Health; Image; Impairment; Individual; Individual Differences; Language; Lead; Lesion; Lobectomy; Mediating; Methods; Modeling; Neurobiology; Neurosciences Research; Participant; Pathway interactions; Pattern; Perception; Peripheral; Phase; Prefrontal Cortex; Process; Prosopagnosia; Research; Resolution; Route; Sampling; Schizophrenia; Sex Discrimination; Signal Transduction; Social Interaction; Social Perception; Social Psychology; Source; Staging; Stimulus; Structure of superior temporal sulcus; System; Testing; Time; Turner' s Syndrome; Visual Pathways; Work; base; causal model; experience; gaze; interest; neuromechanism; patient population; psychologic; relating to nervous system; response; showing emotion; social; theories; trait; visual cognition; visual neuroscience

DESCRIPTION (provided by applicant): Social cues, such as eye gaze, facial and bodily emotion, gender, appearance, have largely been studied independent of one another, often isolated within separate fields. Emotional expression, for example, has been most extensively studied within a social psychological framework, and facial identity largely within a visual cognition framework. Importantly, neither discipline adequately addresses the combined influences of various cues on social perception. This research takes an interdisciplinary, multi-method approach to this question. A conceptual merger is required now, one that focuses specifically on the intersection of social cues in perceptual processing. Because of shared social meanings across cues, we predict that compound social cues will lead to interactions in brain systems known to be important for social and emotion processing, such as the amygdala, orbitofrontal cortex, and superior temporal sulcus. We also predict that under conditions of restricted awareness, responses will be preferentially attuned to congruent (i.e., "clear") cues, whereas for conscious processing they will be preferentially attuned to incongruent (i.e., "ambiguous") threat cues. Research examining the neurobiological underpinnings of affective perception is in its formative stages. In the current application, we contend that social and emotional messages inherently share meaning. If substantiated, the complexities of our nonverbal social language will be more tractable and clearly delineated, and the interplay of reflexive- versus conscious-level processing will be further elucidated. Notably, the brain regions of interest that will be examined have been implicated in the types of socio-emotional impairments that characterize such psychopathological disorders as autism, schizophrenia, borderline personality disorder, and Turner's syndrome, as well as various forms of related brain lesions (e.g., temporal lobectomy). We specifically aim to make significant strides toward future work applying compound social cue theory to patient populations with anxiety disorders and deficits in socio-emotional perception related to the particular brain systems of interest.

描述（由申请人提供）：社会线索，如眼睛凝视，面部和身体情感，性别，外观，在很大程度上是相互独立的研究，往往孤立在不同的领域。例如，情感表达在社会心理学框架内得到了最广泛的研究，而面部识别主要在视觉认知框架内进行。重要的是，这两个学科都没有充分解决各种线索对社会感知的综合影响。本研究采取跨学科、多方法的研究方法。现在需要一个概念的合并，一个专门关注感知处理中社会线索的交叉点的合并。由于各种线索之间具有共同的社会意义，我们预测复合社会线索将导致大脑系统中的相互作用，这些系统对社会和情绪处理至关重要，例如杏仁核、眶额皮质和上级颞沟。我们还预测，在有限的意识条件下，反应将优先调谐到一致（即，“清晰”）线索，而对于有意识的处理，它们将优先调谐到不一致的（即，“模糊的”）威胁线索。考察情感感知的神经生物学基础的研究正处于形成阶段。在本申请中，我们主张社交和情感消息本质上共享含义。如果得到证实，我们的非言语社交语言的复杂性将更容易处理和清晰地描绘，反射与意识层面处理的相互作用将得到进一步阐明。值得注意的是， 将被检查的感兴趣的疾病已经涉及表征诸如自闭症、精神分裂症、边缘型人格障碍和特纳综合征的精神病理学障碍的社会情感障碍的类型，以及各种形式的相关脑损伤（例如，颞叶切除术）。我们的具体目标是在未来的工作中取得重大进展，将复合社会线索理论应用于患有焦虑症和与感兴趣的特定大脑系统相关的社会情感感知缺陷的患者人群。