Behavioral Assessment and Medical (BAM) Core

行为评估和医疗 (BAM) 核心

基本信息

批准号：
9274271
负责人：
ROBERT Kernachan HEATON
金额：
$ 73.61万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9274271
关键词：
4-aminospiroperidol Acquired Immunodeficiency Syndrome Address Adherence Affect Aging Alcohol or Other Drugs use Anemia Animals Attention deficit hyperactivity disorder Automobile Driving Behavior Behavior assessment Biological Assay Biological Markers Blood Blood Vessels Cell Aging Central Nervous System Diseases Cerebrospinal Fluid Clinical Clinical assessments Cognitive Cohort Studies Collaborations Collection Comorbidity Complex Consensus Consequences of HIV Coronary Data Dependence Diabetes Mellitus Diagnosis Disease Disinhibition Drug usage Dyslipidemias Eligibility Determination Emotional Employment Equipment and supply inventories Esthesia Failure Fibrin fragment D Functional disorder Funding HIV HIV-associated neurocognitive disorder Health Hemoglobin Hepatic Human Hypertension Image Impairment Impulsivity Injury Interleukin-6 Intervention Laboratories Lead Leadership Life Liver diseases Longevity Measures Medical Mentors Methamphetamine Methamphetamine dependence Methods Mitochondria Mitochondrial DNA Monitor Moods Nervous System Physiology Neurocognitive Neurocognitive Deficit Neuropathogenesis Outcome Oxidative Stress Participant Pathogenesis Pattern Performance Phenotype Physical Performance Pilot Projects Plasma Public Health Quality of life Recording of previous events Research Research Activity Research Personnel Resources Risk Risk Behaviors Role Specimen Staging Standardization Stroke System Technical Expertise Telomere Shortening Testing Training Transaminases Translational Research Unemployment United States Department of Veterans Affairs Unsafe Sex base co-infection experience frailty functional outcomes immune activation immune function improved indexing innovation instrument multidisciplinary neurobehavioral neurobehavioral disorder neuropsychiatry novel psychosocial repository sample collection social symposium synergism transmission process virtual reality volunteer

项目摘要

The Behavioral Assessment and Medical (BAM) Core is a new component of the competing TMARC renewal, that merges the Clinical Assessment and Laboratory (CAL) and Neuropsychiatric (NP) Cores from the prior funding period to improve resource efficiency. Now comprised of the Neuromedical and Laboratory Unit (NLU) and the Neuropsychiatric Unit (NPU), the BAM Core will extensively contribute to Center objectives by providing to TMARC Projects and Scientific Cores: 1) comprehensive neuromedical and neurobehavioral characterization of human participants, 2) specimen collection/management, and 3) collaboration and training regarding the analyses/interpretation of neuromedical, laboratory, and neurobehavioral data. Standardized neuromedical assessments will focus on aspects of health affected by HIV, METH and aging, including participants' medical and treatment history, neurological functioning, HIV disease staging, and medical comorbidity status (e.g., VACS Index, frailty). Laboratory assessments will include tests for co-infections, clinical lab assays (e.g., hepatic transaminases, hemoglobin), and soluble and cellular biomarkers in cerebrospinal fluid and blood that reflect HIV replication, immune functioning, and oxidative stress. New measures of biologic aging - cell senescence (telomere shortening) and mitochondrial aging (mtDNA injury) are added in support of TMARC's aging theme. The NLU also will provide assays for TMARC's animal projects and support for TMARC's pilot project on cell senescence. The NPU will provide comprehensive neurobehavioral assessments, including neurocognitive abilities, complex frontal systems behaviors (impulsivity/disinhibition, sensation-seeking, and apathy), comorbid psychiatric conditions (mood, ADHD, ASPD, and substance-related), plus key outcomes such as ART adherence, risky behaviors (unsafe sex, drug use, driving), performance-based lADL assessments, independence in real world functioning (e.g., lADLs, employment, health role functioning), psychosocial functioning (social and emotional functioning, quality of life) and support for TMARC's pilot project examining the utility of novel, virtual reality tasks to assess the everyday impact of neurobehavioral impairments due to METH, HIV and aging.

行为评估和医学（BAM）核心是竞争性TMARC续订的新组成部分，该组件合并了临床评估和实验室（CAL）和神经精神病学（NP）核心（NP）核心（NP）核心（NP）核心，以提高资源效率。现在由神经医学和实验室单元（NLU）和神经精神病学部门（NPU）组成，BAM核心将通过为TMARC项目和科学核心提供广泛的贡献，从而为中心目标做出了贡献：1）全面的神经医学和神经性的神经毛发和神经性的参与者，以及针对人类的分析/管理/管理和3）和3），以及3）和3），以及3）和3），以及3）和3），以及3）和3）。神经医学，实验室和神经行为数据。标准化的神经医学评估将集中在受艾滋病毒，甲基苯丙胺和衰老影响的健康方面，包括参与者的医学和治疗史，神经功能功能，艾滋病毒疾病分期以及医疗合并症状态（例如，VACS指数，脆弱）。实验室评估将包括针对共同感染的测试，临床实验室测定（例如，肝转氨酶，血红蛋白）以及脑脊液液和血液中反映HIV复制，免疫功能和氧化应激的血液中的可溶性和细胞生物标志物。为了支持TMARC的衰老主题，添加了生物老化 - 细胞衰老（端粒缩短）和线粒体衰老（mtDNA损伤）的新措施。 NLU还将为TMARC的动物项目提供测定，并支持TMARC的细胞衰老试点项目。 The NPU will provide comprehensive neurobehavioral assessments, including neurocognitive abilities, complex frontal systems behaviors (impulsivity/disinhibition, sensation-seeking, and apathy), comorbid psychiatric conditions (mood, ADHD, ASPD, and substance-related), plus key outcomes such as ART adherence, risky behaviors (unsafe sex, drug use, driving), performance-based LADL评估，现实世界中的独立性（例如LADL，就业，健康角色功能），心理社会功能（社交和情感功能，生活质量）以及对TMARC的试点项目的支持，以研究新颖，虚拟现实任务的实用性，以评估因甲基甲基甲基甲基甲基甲基甲基和脂肪而评估Neurobehavior危害的日常影响。