APOLLO - Upper Midwest
阿波罗 - 上中西部
基本信息
- 批准号:9440897
- 负责人:
- 金额:$ 27.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-25 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:APOL1 geneAcuteAfricanAfrican AmericanApolipoproteinsCaregiversCaringChronic Kidney FailureClinicalDataDecision MakingDiseaseDonor personEnd stage renal failureEpidemiologyEventFibrinogenGenesGeneticGenotypeGoalsGraft SurvivalHospitalsIncidenceIndividualInterventionInvestigationKidneyKidney FailureKidney TransplantationLiving DonorsMidwestern United StatesMonitorNephrologyOperative Surgical ProceduresOrganOrgan DonorOrgan ProcurementsOrgan TransplantationOutcomePopulationPrecipitating FactorsProteinuriaPublic HealthRelative RisksRenal functionResearchResearch PersonnelRiskRisk FactorsSocioeconomic FactorsTransplant RecipientsTransplantationUniversitiesVariantWisconsinbaseclinical riskclinically significantdelayed graft functiongenetic variantgraft failuregraft functionhigh riskmortalityrisk variant
项目摘要
ABSTRACT
Recipients of a kidney transplant from an African-American deceased donor have worse
outcomes than their counterparts receiving an organ from a White deceased donor. The extent
to which this is due to the presence of high-risk APOL1 genotypes in African-American donors is
unknown. Several recent studies have found a positive association between high-risk APOL1
genotypes and graft failure, but these have been based on relatively few events, have come
primarily from a few large centers, and have not analyzed donor-recipient pairs. The proposed
studies will investigate the association of a kidney donor's APOL1 status with recipient
outcomes. We will also study estimate the impact of APLO1 status on living donor outcomes.
We have assembled a consortium including 6 organ procurement organizations covering 7
states in the Upper Midwest, 123 recovering hospitals, 25 transplant centers and collaborators
in transplant surgery, transplant nephrology, epidemiology and genetics to achieve these goals.
These findings will provide a greater understanding of the impact of the presence of high-risk
APOL1 variants in both recipients and living donors. These data are needed for informed
decision-making for recipients, potential living donors, and their caregivers. Both the relative and
absolute risk of clinically significant events associated with high-risk APOL1 variants will be
estimated with much greater precision that previous studies, allowing more informed decisions
on acceptance of specific organs for transplantation.
摘要
接受非裔美国人已故捐赠者肾移植的患者情况更糟,
从白色死者捐赠者那里获得器官的结果。程度
这是由于非洲裔美国人供体中存在高风险APOL 1基因型,
未知最近的几项研究发现,高风险APOL 1
基因型和移植失败,但这些都是基于相对较少的事件,
主要来自几个大的中心,并且没有分析供体-受体对。拟议
研究将调查肾脏捐献者的APOL 1状态与受体的关系,
结果。我们还将研究评估APLO 1状态对活体供体结果的影响。
我们组建了一个包括6个器官采购组织的联盟,涵盖7个
上中西部各州、123家康复医院、25个移植中心和合作者
在移植手术、移植肾脏学、流行病学和遗传学中实现这些目标。
这些发现将使人们更好地了解高风险的存在所产生的影响。
受体和活体供体中的APOL 1变体。需要这些数据来了解
接受者、潜在活体捐赠者及其护理人员的决策。无论是相对的,
与高风险APOL 1变异体相关的临床显著事件的绝对风险将是
比以前的研究更精确地估计,从而做出更明智的决定
接受特定的器官移植。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brad C Astor其他文献
Brad C Astor的其他文献
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{{ truncateString('Brad C Astor', 18)}}的其他基金
Dynamic Prediction of Renal Failure Using Longitudinal Prognostic Information among Patients with Chronic Kidney Disease and Kidney Transplant
利用慢性肾病和肾移植患者的纵向预后信息动态预测肾衰竭
- 批准号:
10369592 - 财政年份:2019
- 资助金额:
$ 27.28万 - 项目类别:
Dynamic Prediction of Renal Failure Using Longitudinal Prognostic Information among Patients with Chronic Kidney Disease and Kidney Transplant
利用慢性肾病和肾移植患者的纵向预后信息动态预测肾衰竭
- 批准号:
9912766 - 财政年份:2019
- 资助金额:
$ 27.28万 - 项目类别:
1/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
1/14 APOL1长期肾移植结果网络(APOLLO)临床中心
- 批准号:
10731266 - 财政年份:2017
- 资助金额:
$ 27.28万 - 项目类别:
Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
慢性肾脏病的预测因素和后果的纵向研究
- 批准号:
8145010 - 财政年份:2010
- 资助金额:
$ 27.28万 - 项目类别:
Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
慢性肾脏病的预测因素和后果的纵向研究
- 批准号:
7179560 - 财政年份:2007
- 资助金额:
$ 27.28万 - 项目类别:
Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
慢性肾脏病的预测因素和后果的纵向研究
- 批准号:
7470898 - 财政年份:2007
- 资助金额:
$ 27.28万 - 项目类别:
Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
慢性肾脏病的预测因素和后果的纵向研究
- 批准号:
7568799 - 财政年份:2007
- 资助金额:
$ 27.28万 - 项目类别:
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