APOLLO - Upper Midwest

阿波罗 - 上中西部

• 批准号: 9977188
• 负责人: Brad C Astor
• 金额: $ 34.11万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9977188
• 关键词: APOL1 gene; Acute; African; African American; Apolipoproteins; Caregivers; Caring; Chronic Kidney Failure; Clinical; Data; Decision Making; Disease; Donor person; End stage renal failure; Epidemiology; Event; Fibrinogen; Genes; Genetic; Genotype; Goals; Graft Survival; Hospitals; Incidence; Individual; Intervention; Investigation; Kidney; Kidney Failure; Kidney Transplantation; Living Donors; Midwestern United States; Monitor; Nephrology; Organ; Organ Donor; Organ Procurements; Organ Transplantation; Outcome; Population; Precipitating Factors; Proteinuria; Public Health; Relative Risks; Renal function; Research; Research Personnel; Risk; Risk Factors; Socioeconomic Factors; Transplant Recipients; Transplantation; Transplantation Surgery; Universities; Variant; Wisconsin; base; clinical risk; clinically significant; delayed graft function; genetic variant; graft failure; graft function; high risk; living kidney donor; mortality; risk variant; transplant centers

ABSTRACT Recipients of a kidney transplant from an African-American deceased donor have worse outcomes than their counterparts receiving an organ from a White deceased donor. The extent to which this is due to the presence of high-risk APOL1 genotypes in African-American donors is unknown. Several recent studies have found a positive association between high-risk APOL1 genotypes and graft failure, but these have been based on relatively few events, have come primarily from a few large centers, and have not analyzed donor-recipient pairs. The proposed studies will investigate the association of a kidney donor's APOL1 status with recipient outcomes. We will also study estimate the impact of APLO1 status on living donor outcomes. We have assembled a consortium including 6 organ procurement organizations covering 7 states in the Upper Midwest, 123 recovering hospitals, 25 transplant centers and collaborators in transplant surgery, transplant nephrology, epidemiology and genetics to achieve these goals. These findings will provide a greater understanding of the impact of the presence of high-risk APOL1 variants in both recipients and living donors. These data are needed for informed decision-making for recipients, potential living donors, and their caregivers. Both the relative and absolute risk of clinically significant events associated with high-risk APOL1 variants will be estimated with much greater precision that previous studies, allowing more informed decisions on acceptance of specific organs for transplantation.

摘要 接受非裔美国人已故捐赠者肾移植的患者情况更糟， 从白色死者捐赠者那里获得器官的结果。程度 这是由于非洲裔美国人供体中存在高风险APOL 1基因型， 未知最近的几项研究发现，高风险APOL 1 基因型和移植失败，但这些都是基于相对较少的事件， 主要来自几个大的中心，并且没有分析供体-受体对。拟议 研究将调查肾脏捐献者的APOL 1状态与受体的关系， 结果。我们还将研究评估APLO 1状态对活体供体结果的影响。 我们组建了一个包括6个器官采购组织的联盟，涵盖7个 上中西部各州、123家康复医院、25个移植中心和合作者 在移植手术、移植肾脏学、流行病学和遗传学方面，以实现这些目标。 这些发现将使人们更好地了解高风险的存在所产生的影响。 受体和活体供体中的APOL 1变体。需要这些数据来了解 接受者、潜在活体捐赠者及其护理人员的决策。无论是相对的， 与高风险APOL 1变异体相关的临床显著事件的绝对风险将是 比以前的研究更精确地估计，从而做出更明智的决定 接受特定的器官移植。