REGULATORY FACTORS IN THE GI TRACT

胃肠道的调节因素

• 批准号: 7007348
• 负责人: ELLEN LI
• 金额: $ 111.31万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7007348
• 关键词: biomedical facility; clinical research; gastrointestinal system

DESCRIPTION (provided by applicant): This application is for continued support of the Digestive Diseases Research Core Center (DDRCC) at Washington University St. Louis, focusing on regulatory factors in the GI tract. We believe that by gaining a fundamental understanding of the regulation of GI-processes, we will be able to more rationally prevent and treat GI diseases, including peptic ulcer, inflammatory bowel disease and acute and chronic liver diseases. Our philosophy is that the most effective way to develop new opportunities in digestive diseases related research is to invest in motivated individuals, especially at early stages of their careers. Consequently, the Washington University DDRCC focuses on mentoring and training students, residents, fellows and junior faculty with the goal of fostering new independent investigators in digestive diseases-related research. This center has excelled in developing young independent researchers though our Pilot/Feasibility Program. Our success can also be measured by the fact that both total extramural and NIDDK digestive diseases-related research base has more than doubled since the center's inception in 2000. The programmatic themes of the Digestive Diseases Research Core Center reflect its outstanding research base and are: 1.) Host-microbial interactions, inflammation and mucosal immunity; 2.) Gut development, differentiation and epithelial renewal; 3.) Nutrient transport, metabolism and signaling; 4.) Hepatobiliary metabolism, injury-repair. Washington University DDRCC investigators have been at the forefront in each of these programmatic themes. Partnership between a junior DDRCC investigator and clinical gastroenterologist has led to a novel paradigm in the treatment of inflammatory bowel disease. DDRCC investigators have pioneered the use of DNA microarray analyses of laboratory and clinical human samples to identify novel biomarkers and mediators in each of the four programmatic themes. These successes have in turn prompted us to propose to expand the Research Core services, including gnotobiotics, laser capture microdissection, DNA microarray, proteomics and bioinformatics. The goals of this DDRCC are to continue to promote and enhance interdisciplinary digestive disease research through its four research core facilities (Murine Models, Morphology, Functional Genomics and Proteomics).

描述（由申请人提供）： 此申请是为了继续支持华盛顿大学圣路易斯分校的消化系统疾病研究核心中心（DDRCC），重点是胃肠道中的调节因子。我们相信，通过对GI过程调控的基本了解，我们将能够更合理地预防和治疗GI疾病，包括消化性溃疡，炎症性肠病和急性和慢性肝病。我们的理念是，在消化系统疾病相关研究中开发新机会的最有效方法是投资于有动力的个人，特别是在他们职业生涯的早期阶段。因此，华盛顿大学DDRCC专注于指导和培训学生、住院医师、研究员和初级教师，目标是培养消化系统疾病相关研究的新独立研究人员。该中心通过我们的试点/可行性计划在发展年轻的独立研究人员方面表现出色。我们的成功也可以通过这样一个事实来衡量，即自2000年该中心成立以来，总的校外和NIDDK消化系统疾病相关的研究基础已经翻了一番多。消化系统疾病研究核心中心的纲领性主题反映了其杰出的研究基础，是：1。宿主-微生物相互作用、炎症和粘膜免疫; 2.）肠发育、分化和上皮更新; 3.）营养物质运输、代谢和信号传导; 4.）肝胆代谢、损伤修复。华盛顿大学DDRCC研究人员一直在这些方案主题的最前沿。DDRCC初级研究者和临床胃肠病学家之间的合作关系为炎症性肠病的治疗带来了新的范例。DDRCC研究人员率先使用实验室和临床人体样本的DNA微阵列分析，以确定四个方案主题中的每一个的新生物标志物和介质。这些成功反过来又促使我们建议扩大研究核心服务，包括gnotobiotics，激光捕获显微切割，DNA微阵列，蛋白质组学和生物信息学。该DDRCC的目标是通过其四个研究核心设施（小鼠模型，形态学，功能基因组学和蛋白质组学）继续促进和加强跨学科的消化系统疾病研究。