REGULATORY FACTORS IN THE GI TRACT

此申请是为了建立消化系统疾病研究 圣路易斯华盛顿大学医学院（WUMS）核心中心（DDRCC）， 专注于胃肠道中的调节因子。解甲返乡协调中心的概念 从大量的合作和协同互动中产生 从事消化疾病相关研究的研究人员，并将 包括临床和基础科学领域的36名主要研究人员 华盛顿大学医学院的部门作为正式成员。 华盛顿大学DDRCC的目标是：1）正式化， 提供扩大广泛协作和协同的机制， 许多独立供资的机构之间已经有互动， 从事消化系统疾病相关研究的研究人员; 2）汇集 部门和司的资源，以提供服务和专门知识， 可能无法以其他方式提供给个别研究人员， （3）为调查人员提供资助， 消化系统疾病相关的研究计划，随后将 竞争更传统的融资机制。的部件 描述（直接取自应用程序） DDRCC包括转基因小鼠/干细胞核心设施，形态学核心设施， 实验室，细胞生物学核心实验室和蛋白质结构和大分子 图形核心设施。这四个核心的设计，以方便分析 体内和体外胃肠道中的调节因子，以及 将结构与功能联系起来。这些核心在许多情况下将扩大 现有的小型设施。行政核心将监督 整个DDRCC的运行。它还将管理P/F计划， 鼓励年轻和成熟的研究人员参与， 消化系统疾病相关研究。此外，NIH赞助的一般 华盛顿大学的临床研究中心将提供DDRCC 参与者拥有进行临床研究的资源，目前正在 DDRCC的几个主要成员正在使用，他们是 翻译GI研究。这些组成部分和目标合在一起， 在华盛顿大学医学院定义DDRCC。

This application is for the establishment of the Digestive Diseases Research Core Center (DDRCC) at Washington University Medical School (WUMS), St. Louis, focusing on regulatory factors in the GI tract. The concept of a DDRCC has emerged from the collaborative and synergistic interactions of a large number of investigators engaged in digestive-diseases related research, and will include thirty-six principal investigators in the clinical and basic science departments of the Washington University School of Medicine as full members. The goals for the DDRCC at Washington University are to 1) formalize and provide mechanisms for expanding the extensive collaborative and synergistic interactions already in place between a large number of independently funded investigators engaged in digestive-diseases related research; 2) pool departmental and divisional resources to provide services and expertise that may otherwise not be available to individual investigators, in a cost-effective manner; and 3) provide funding support for investigators to develop new digestive-diseases related research initiatives that will subsequently be competitive for more conventional mechanisms of funding. The components of the DESCRIPTION (Taken directly from the application) DDRCC include a Transgenic Mouse/Stem Cell Core Facility, a Morphology Core Facility, Cell Biology Core facility and a Protein Structure and Macromolecular Graphics Core Facility. These four cores are designed to facilitate analysis of the regulatory factors in the GI tract both in vivo and in vitro, and to correlate structure with function. These cores in many cases will be expanded from existing mini-facilities. The Administrative Core will oversee the operation of the DDRCC as a whole. It will also administer the P/F program to foster participation by younger and established investigators in digestive-diseases related research. In addition, the NIH-sponsored General Clinical Research Center at Washington University will provide DDRCC participants with resources for conducting clinical research, and is currently being utilized by several key members of the DDRCC who are experts in translational GI research. Taken together, these components and objectives define the DDRCC at the Washington University School of Medicine.