REGULATORY FACTORS IN THE GI TRACT

本申请是为建立消化系统疾病研究室而准备的 华盛顿大学医学院核心中心(DDRCC)，圣路易斯， 关注胃肠道的调节因素。DDRCC的概念有 从大量的协作和协同互动中涌现出来 从事消化系统疾病相关研究的研究人员，并将 包括36名临床和基础科学领域的主要研究人员 华盛顿大学医学院院系为正式成员。 华盛顿大学DDRCC的目标是1)正规化和 提供扩展广泛的协作性和协同性的机制 已经在大量独立资助的 从事消化系统疾病相关研究的调查人员；2)人才库 部门和部门资源，以提供下列服务和专业知识 可能无法以其他方式提供给个人调查人员，以经济高效的方式 方式；3)为调查人员提供资金支持，以开发新的 与消化疾病相关的研究倡议，随后将 在更传统的筹资机制方面具有竞争力。的组件 描述(直接从应用程序中获取) DDRCC包括转基因小鼠/干细胞核心设施，形态核心 设施、细胞生物学核心设施和蛋白质结构与大分子 图形核心设备。这四个内核的设计目的是方便分析 在体内和体外的胃肠道调节因子，以及 将结构与功能联系起来。在许多情况下，这些核心将被扩展 从现有的迷你设施。行政核心将监督 复员方案协调委员会作为一个整体的运作。它还将管理P/F计划以 促进年轻和成熟的调查人员参与 消化系统疾病的相关研究。此外，由美国国立卫生研究院赞助的将军 华盛顿大学临床研究中心将提供DDRCC 参与者拥有进行临床研究的资源，目前正在 被DDRCC的几个关键成员利用，他们是 翻译GI研究。总而言之，这些组件和目标 在华盛顿大学医学院定义DDRCC。

This application is for the establishment of the Digestive Diseases Research Core Center (DDRCC) at Washington University Medical School (WUMS), St. Louis, focusing on regulatory factors in the GI tract. The concept of a DDRCC has emerged from the collaborative and synergistic interactions of a large number of investigators engaged in digestive-diseases related research, and will include thirty-six principal investigators in the clinical and basic science departments of the Washington University School of Medicine as full members. The goals for the DDRCC at Washington University are to 1) formalize and provide mechanisms for expanding the extensive collaborative and synergistic interactions already in place between a large number of independently funded investigators engaged in digestive-diseases related research; 2) pool departmental and divisional resources to provide services and expertise that may otherwise not be available to individual investigators, in a cost-effective manner; and 3) provide funding support for investigators to develop new digestive-diseases related research initiatives that will subsequently be competitive for more conventional mechanisms of funding. The components of the DESCRIPTION (Taken directly from the application) DDRCC include a Transgenic Mouse/Stem Cell Core Facility, a Morphology Core Facility, Cell Biology Core facility and a Protein Structure and Macromolecular Graphics Core Facility. These four cores are designed to facilitate analysis of the regulatory factors in the GI tract both in vivo and in vitro, and to correlate structure with function. These cores in many cases will be expanded from existing mini-facilities. The Administrative Core will oversee the operation of the DDRCC as a whole. It will also administer the P/F program to foster participation by younger and established investigators in digestive-diseases related research. In addition, the NIH-sponsored General Clinical Research Center at Washington University will provide DDRCC participants with resources for conducting clinical research, and is currently being utilized by several key members of the DDRCC who are experts in translational GI research. Taken together, these components and objectives define the DDRCC at the Washington University School of Medicine.