High Performance Computing for Multiscale Modeling of Biological Systems

用于生物系统多尺度建模的高性能计算

• 批准号: 9278815
• 负责人: Ivet Bahar
• 金额: $ 157.62万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9278815
• 关键词: Address; Automobile Driving; Award; BRAIN initiative; Big Data; Binding; Biological; Biological Process; Biological Sciences; Biomedical Research; Biomedical Technology; Brain; Cell model; Cellular Structures; Cellular biology; Chromatin Structure; Collaborations; Communities; Computational Biology; Computer software; Computing Methodologies; Data; Development; Educational workshop; Ensure; Environment; Event; Feedback; Florida; Functional disorder; Funding; Future; Genetic Transcription; Genomics; Goals; High Performance Computing; Image; Immune System Diseases; Institutes; Institution; Interdisciplinary Study; Internet; Intervention; Joints; Laboratories; Lead; Length; Light; Maps; Methods; Mission; Modeling; Molecular; Molecular Models; Molecular Structure; Morphology; Nervous system structure; Neurobiology; Neurotransmitters; Process; Regulation; Research; Research Personnel; Research Training; Resources; Science; Scientist; Series; Services; Signal Transduction; Software Tools; Structure; Supercomputing; Synapses; Synaptic plasticity; System; Systems Biology; T-Lymphocyte; Technology; Training; United States National Institutes of Health; Universities; Vision; austin; base; bioimaging; biological research; biological systems; computerized tools; data to knowledge; design; dopamine transporter; experience; fascinate; innovation; meetings; member; molecular modeling; multi-scale modeling; nanoscale; network models; neurotransmission; novel; program dissemination; programs; research and development; simulation; social media; spatiotemporal; structural biology; synaptic function; technology development; tool; trafficking; web portal

I. Overall - Abstract We propose to renew the Biomedical Technology and Research Resource (BTRR) on High Performance Computing for Multiscale Modeling of Biological Systems, hereafter referred to as MMBioS. MMBioS is a joint effort between the University of Pittsburgh (Pitt; lead institution), Carnegie Mellon University (CMU), the Pittsburgh Supercomputing Center (PSC), and the Salk Institute for Biological Studies (Salk). Our mission is to continue to develop computational methods and usable software tools to advance research and training at the interface between computing technology and life sciences. Our biological theme remains: realistic and efficient modeling, analysis and simulations of molecular and cellular structure and dynamics toward understanding and predicting the origin and mechanism of biological function/dysfunction at multiple scales, with focus on synaptic signaling and regulation events, thus facilitating the discovery of new treatments against nervous and immune systems' disorders. Building on the progress made during the past award in starting to fill the gap between modeling efforts at disparate scales of structural biology, cellular microphysiology and large- scale bioimage analysis, we now further expand our efforts toward developing more powerful tools and an integrated platform for efficient implementation and use of our technology. We have increased the scope and number of our Technology Research and Development Projects from 3 to 4, to advance and enable the adaptation of molecular modeling (TR&D1), cell modeling (TR&D2), (cellular) network modeling (TR&D3), and image-derived modeling (TR&D4) methods and software to new challenges. These are driven by seven Driving Biomedical Projects (DBPs) on: the dynamics of neurotransmitter transporters at both molecular and cellular levels (DBP1; NIH and U of Florida); regulation and binding to PSD-95 and its relation to AMPAR trafficking (DBP2; Caltech), multiscale modeling of dopamine transporter function (DBP3; Pitt); spatiotemporal modeling of T cell signaling (DBP4; Bristol, UK); constructing a dynamic, spatial map of transcription and chromatin structure (DBP6; NIH); structure and function of synapses (DBP7; UT Austin); and scalable approaches to modeling using large sets of rules and images (DBP8; Harvard). Previous DBP5 (Allen Brain Institute) on functional connectomics has been successfully completed. We will continue our vigorous training and dissemination programs, and a broad range of Collaboration of Service Projects (C&SPs), taking advantage of the unique experience and capabilities of the PSC, the strengths of the Departments of Computational and Systems Biology (Pitt) and Computational Biology (CMU), and cutting-edge research at the Computational Neurobiology Laboratory at Salk.

I.总体-摘要 我们建议更新生物医学技术和研究资源（BTRR）的高 生物系统多尺度建模的性能计算，以下简称为 MMBioS。MMBioS是匹兹堡大学（皮特;牵头机构），卡内基 梅隆大学（CMU）、匹兹堡超级计算中心（PSC）和索尔克研究所 生物学研究（索尔克）。我们的使命是继续发展计算方法和可用的 在计算技术与生活之间的界面上推进研究和培训的软件工具 以理工科为重我们的生物主题仍然是：现实和有效的建模，分析和模拟 分子和细胞结构和动力学，以了解和预测起源， 在多个尺度上的生物功能/功能障碍的机制，重点是突触信号传导和 调节事件，从而促进发现针对神经和免疫的新疗法。 系统紊乱在上一次颁奖期间取得的进展基础上，开始填补差距 在不同尺度的结构生物学、细胞微生理学和大型生物学的建模工作之间， 规模生物图像分析，我们现在进一步扩大我们的努力，开发更强大的工具， 高效实施和使用我们技术的集成平台。我们加大 我们的技术研究和开发项目的范围和数量从3到4，以推进和 使分子建模（TR&D1），细胞建模（TR&D2），（细胞）网络的适应 建模（TR&D3）和图像衍生建模（TR&D4）方法和软件的新挑战。 这些是由七个驱动生物医学项目（DBP）驱动的：神经递质的动态 分子和细胞水平的转运蛋白（DBP 1; NIH和U of佛罗里达）;调节和结合 PSD-95及其与AMPAR运输（DBP 2; Caltech）的关系，多巴胺的多尺度建模 转运蛋白功能（DBP 3; Pitt）; T细胞信号传导的时空建模（DBP 4;布里斯托，英国）; 构建转录和染色质结构的动态空间图（DBP 6; NIH）;结构和 突触功能（DBP 7; UT Austin）;以及使用大型规则集进行建模的可扩展方法 和图像（DBP 8;哈佛）。上一篇DBP 5（艾伦脑研究所）对功能性连接组学的研究 已成功完成。我们将继续大力开展培训和宣传活动， 广泛的服务项目合作（C& SP），利用独特的经验 和PSC的能力，计算和系统生物学系的优势 （皮特）和计算生物学（CMU），以及计算神经生物学的前沿研究 实验室在Salk。