EDAC: ENCODE Data Analysis Center

EDAC：ENCODE数据分析中心

• 批准号: 9248178
• 负责人: Mark Bender Gerstein
• 金额: $ 200万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2021-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9248178
• 关键词: ATAC-seq; Alleles; Alpha Cell; Binding; Biochemical; Biological; Biological Assay; Biophysics; Catalogs; ChIP-seq; Chromatin; Collaborations; Communities; Computational Biology; Computing Methodologies; DNA Methylation; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Element; Data Set; Deoxyribonucleases; Development; Disease; Elements; Encyclopedia of DNA Elements; Encyclopedias; Enhancers; Epigenetic Process; Event; Evolution; Feedback; Genes; Genetic; Genetic Transcription; Genome; Genomic Segment; Genomics; Genotype-Tissue Expression Project; Goals; Guidelines; Health; Human; Human Biology; Human Genome; Intuition; Leadership; Location; Machine Learning; Manuscripts; Measures; Metadata; Methods; Mus; National Human Genome Research Institute; Nucleotides; Pathway Analysis; Process; Proteomics; Publications; RNA; RNA-Binding Proteins; Recording of previous events; Records; Reporting; Reproducibility; Research; Research Infrastructure; Research Personnel; Resolution; Resource Informatics; Resources; Science; Signal Transduction; Standardization; Subgroup; Techniques; The Cancer Genome Atlas; Transcriptional Regulation; Variant; Work; Writing; base; bisulfite sequencing; cell type; comparative; computerized data processing; data exchange; data integration; experience; experimental study; functional genomics; genetic variant; genome wide association study; high throughput analysis; histone modification; insight; member; mouse genome; novel; symposium; transcription factor; transcriptome sequencing; whole genome; working group

PROJECT SUMMARY The goal of the Encyclopedia of DNA Elements (ENCODE) project is to catalog all functional elements in the human genome through the integration and analysis of high-throughput data. We propose to continue the ENCODE Data Analysis Center (EDAC, DAC) which will provide support and leadership in analyzing and integrating data from the ENCODE project as well as work closely with other ENCODE groups including the Data Coordination Center. Our proposed DAC team (Zhiping Weng, Mark Gerstein, Manolis Kellis, Roderic Guigo, Rafael Irizarry, X. Shirley Liu, Anshul Kundaje, and William Noble) has expertise across a wide range of fields including transcriptional regulation, epigenetics, evolution, genomics and proteomics, regulatory RNA, biophysics, and computational biology, where they are the leaders in machine learning, statistical genetics, networks, and gene annotation. These investigators also have a history of successfully working collaboratively in large consortia, particularly with other ENCODE groups. Their publication records demonstrate their synergistic approach to producing high-impact science and useful resources that benefit the broader biomedical communities. The proposed DAC will pursue the following four aims: Aim 1. Analyze and integrate data and metadata from a broad range of functional genomics projects; Aim 2. Serve as an informatics resource by supporting the activities of the ENCODE Analysis Working Group; Aim 3. Create high-quality Encyclopedias of DNA elements in the human and mouse genomes; Aim 4. Assess quality and utility of the ENCODE data and provide feedback to NHGRI and the Consortium.

项目总结 DNA元素百科全书(ENCODE)项目的目标是将 通过整合和分析人类基因组的高通量数据。我们建议继续 编码数据分析中心(EDAC、DAC)，该中心将在分析和 整合ENCODE项目的数据并与其他ENCODE小组密切合作，包括 数据协调中心。我们建议的DAC团队(翁志平，马克·格斯坦，马诺利斯·凯利斯，罗德里克 Guigo、Rafael Irizarry、X.Shirley Liu、Anshul Kundaje和William Noble)拥有广泛的专业知识 包括转录调控、表观遗传学、进化、基因组和蛋白质组学、调控RNA、 生物物理学和计算生物学，他们是机器学习、统计遗传学、 网络和基因注释。这些调查人员也有成功合作的历史 在大型财团中，特别是与其他ENCODE集团。他们的出版记录证明了他们的 以协同方法产生高影响力的科学和有用的资源，使更广泛的人受益 生物医学社区。 拟议的发文咨询委员会将追求以下四个目标：目标1.分析和整合来自 广泛的功能基因组学项目；目标2。作为信息学资源，支持 编码分析工作组的活动；目标3.创建高质量的DNA元素百科全书 在人类和小鼠基因组中；目标4.评估编码数据的质量和用途，并提供 向NHGRI和财团提供反馈。