CDU Diversity-promoting Institutions Drug Abuse Research Development Program

描述(申请人提供)：尽管NIDA和其他机构的戒烟努力取得了成功，但仍有数百万美国人在继续吸烟。此外，我们的实验室还发现了尼古丁对代谢影响的重要结果，包括尼古丁加上高脂肪饮食(HFD)会导致肝脏和肌肉脂肪变性。我们还使用了一个大型数据库，显示二手烟与糖尿病和肥胖症都有关联。这导致我们将查尔斯·R·德鲁医学与科学大学(CDU)促进机构药物滥用研究计划(DIDARP)的主题定为“尼古丁的新陈代谢影响：它很重要”。我们的培训主题将继续是以美国国立卫生研究院路线图为基础的“未来研究团队”。我们的培训计划将侧重于所有级别的少数族裔受训人员，并通过解决药物滥用问题从长远来看有所不同。该DIDARP的研究、培训和教育计划的总体目标是提高CDU进行物质滥用研究的能力，主要关注尼古丁的代谢影响。CDU DIDARP的具体目标是：1.增加与尼古丁代谢影响有关的高质量药物成瘾研究项目的数量，使CDU能够发展专业知识和获得初步数据，以便能够竞争NIDA P01、P50或ROI补助金；2.通过提供有意义的教育和研究经验，继续培养未被充分代表的学生和其他受训人员对药物滥用研究的兴趣；以及3.继续加强CDU的研究基础设施，以支持药物滥用研究。为了实现这些目标，我们将有3个相关的跨学科项目：项目1：尼古丁加剧高脂肪饮食诱导 肥胖小鼠的肝脏脂肪变性和骨骼肌异常。试点项目A：了解多巴胺在暴饮暴食、尼古丁和酒精使用中的作用：一项翻译PET研究。试点项目B：二手烟与糖尿病、肥胖症和其他慢性病的关系。实现这些目标最终将有助于减少与药物滥用有关的健康差距。

DESCRIPTION (provided by applicant): Although smoking cessation efforts by NIDA and others have been successful, millions of Americans continue to smoke. Additionally, our laboratories have found important results on the metabolic effects of nicotine, including findings that nicotine plus a high fat diet (HFD) leads to hepatic and muscle steatosis. We have also used a large database to show that secondhand smoke is associated with both diabetes and obesity. This has led us to develop the theme of the Charles R. Drew University of Medicine and Science (CDU) Diversity-Promoting Institution Drug Abuse Research Program (DIDARP) to be "Metabolic Effects of Nicotine: it Matters." Our training theme will continue to be "Research Teams of the Future" that is based on the NIH roadmap. Our training program will focus on minority trainees at all levels and make a difference in the long run by tackling the problem of substance abuse. The overarching goal of the research, training and education programs of this DIDARP are to enhance CDU's capacity to conduct substance abuse research with a primary focus on the metabolic effects of nicotine. The specific goals of CDU DIDARP are: 1. To increase the number of high quality drug addiction research projects related to the metabolic effects of nicotine to allow CDU to develop expertise and acquire preliminary data to be able to compete for NIDA P01, P50 or ROI grants; 2. To continue to foster interest in substance abuse research among under-represented students and other trainees by providing meaningful educational and research experiences; and 3. To continue to enhance the research infrastructure at CDU to support substance abuse research. To achieve these goals, we will have 3 related, cross-disciplinary projects: Project 1: Nicotine exacerbates high fat diet-induced hepatic steatosis and skeletal muscle abnormalities in obese mice. Pilot Project A: Understanding the role of dopamine in binge-eating, nicotine and alcohol use: a translational PET study. Pilot Project B: The association between secondhand smoking and diabetes, obesity and other chronic diseases. Achieving these goals will eventually help reduce the health disparities as related to substance abuse.