Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart Disease
脑动脉完整性与先天性心脏病的脑损伤和认知有关
基本信息
- 批准号:9157665
- 负责人:
- 金额:$ 50.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2020-05-31
- 项目状态:已结题
- 来源:
- 关键词:18 year oldAdolescentAffectAgeAlzheimer&aposs DiseaseAreaArteriesBloodBlood capillariesBrainBrain InjuriesBrain regionCognitionCognitiveCognitive deficitsComparative StudyCongenital AbnormalityCongenital Heart DefectsContrast MediaDataDiabetes MellitusDiffusion Magnetic Resonance ImagingDiseaseEndotheliumEpilepsyGenderHippocampus (Brain)HypertensionHypoxemiaHypoxiaImage AnalysisImaging TechniquesInjuryInvestigationLanguageLeadLearningLinkLow Cardiac OutputMagnetic Resonance ImagingMeasuresMemoryMeningitisMorbidity - disease rateMultiple SclerosisOperative Surgical ProceduresParietalPatientsPerformancePilot ProjectsPopulationProceduresProcessPublic HealthPublishingQuality of lifeRadiationRegional PerfusionReportingResearchResearch DesignSample SizeSamplingSchoolsSiteSpin LabelsStrokeTimeTissuesTraumatic Brain InjuryTravelVisuospatialbasebrain tissuecapillarycerebral arterycognitive functioncognitive testingcongenital heart disorderdiffusion weightedeffective interventioneffective therapyexecutive functionfrontal lobehigh riskimprovedinclusion criteriaindexingmortalitynerve injurypalliationpatient populationpreventrelating to nervous systemrepairedwater diffusion
项目摘要
PROJECT SUMMARY/ ABSTRACT
Adolescents with congenital heart disease (CHD) show brain injury in regions (hippocampus, frontal
cortex, temporal, and parietal), which control cognition. Abnormalities in these sites are associated with
cognitive deficits. However, the underlying cause of brain injury in these areas in CHD is unclear. Alteration in
cerebral artery integrity (measured by arterial transit time [ATT]), which is associated with neural injury in other
diseases, is a potential cause of brain injury in CHD. However, there are no published reports of cerebral artery
integrity in CHD or regarding any associations between cerebral artery integrity, brain injury, and cognition in
this condition. We will use a comparative study design, 80 subjects (40 CHD / 40 Healthy controls), with
inclusion criteria for CHD will be subjects between 14-18 years of age, have undergone surgical repair or
palliation, and controls will be age- and gender-matched to CHD subjects. Using non-invasive brain magnetic
resonance imaging (MRI) procedures, our preliminary study is the first to report abnormalities in ATT values
(via diffusion-weighted pseudo-continuous arterial spin labeling [pCASL] procedures) in CHD and that these
changes are associated with brain injury (as examined by diffusion tensor imaging based mean diffusivity [MD],
an MRI measure of tissue integrity) in the hippocampus, frontal cortex, temporal, and parietal regions in CHD
subjects compared to controls. However, while promising, the sample size in this preliminary study was quite
small and did not allow us to control for important covariates, such as age and gender. Therefore, the specific
aims of this proposal are to: 1) compare ATT values (calculated from diffusion-weighted pCASL) between CHD
and age- and gender-matched control subjects; 2) compare regional MD values, derived from diffusion tensor
imaging data and cognitive scores (measured by the total Montreal Assessment of Cognition [MoCA] and
general memory index (GMI) score from the Wide Range Assessment of Memory and Learning [WRAML2])
between CHD and age- and gender-matched control subjects; 3) examine the relationships between altered
ATT (indicating cerebral artery integrity), regional MD values (assessment of injury), and cognitive scores in
CHD patients.
In summary, CHD patients show significant brain injury in areas that control cognition. These deficits are
associated with poor school performance, increased morbidity and mortality, and poorer quality of life. A
potential cause of this brain injury may be compromised cerebral artery integrity; however, status of the artery
integrity and its association with brain injury and cognition has not been reported in CHD. Information from
this study has the potential to disclose a process contributing to brain injury in CHD. Thus, it has important
implications on identification of effective treatments for CHD by repairing cerebral artery integrity as used in
other conditions (such as stroke and traumatic brain injury), which could dramatically improve cognitive
function, reduce mortality and morbidity, and increase quality of life in this high risk patient population.
项目摘要/摘要
先天性心脏病(CHD)青少年表现为脑部损伤(海马体、额叶
大脑皮层、颞叶和顶叶),它们控制认知。这些部位的异常与
认知缺陷。然而,CHD患者这些区域脑损伤的潜在原因尚不清楚。更改中
脑动脉完整性(以动脉通过时间[ATT]衡量),这与其他患者的神经损伤有关
疾病,是CHD脑损伤的潜在原因。然而,目前还没有关于脑动脉的报道。
CHD的完整性或关于脑动脉完整性、脑损伤和认知之间的任何联系
这种情况。我们将采用比较研究设计,80名受试者(40名CHD/40名健康对照),
冠心病的纳入标准将包括年龄在14-18岁之间、接受过手术修复或
缓解,对照将与CHD受试者的年龄和性别匹配。使用非侵入性脑磁力
在磁共振成像(MRI)过程中,我们的初步研究首次报告了ATT值的异常
(通过扩散加权伪连续动脉自旋标记[pCASL]程序)治疗CHD,这些
变化与脑损伤相关(如通过基于扩散张量成像的平均扩散系数[MD]检查,
冠心病患者的海马区、额叶皮质、颞区和顶区的组织完整性的MRI测量
受试者与对照组的比较。然而,尽管前景看好,但这项初步研究的样本量相当大。
很小,不允许我们控制重要的协变量,如年龄和性别。因此,具体的
该建议的目的是:1)比较CHD和CHD之间的ATT值(根据扩散加权的pCASL计算
和年龄和性别匹配的对照受试者;2)比较由扩散张量得出的区域MD值
成像数据和认知分数(由蒙特利尔认知评估[MoCA]和
记忆和学习广度评估的一般记忆指数(GMI)得分[WRAML2])
冠心病与年龄和性别匹配的对照组之间的关系;3)检查改变与
ATT(指示大脑动脉完整性)、区域MD值(损伤评估)和认知评分
冠心病患者。
总而言之,CHD患者在控制认知的区域表现出明显的脑损伤。这些赤字是
与学业成绩差、发病率和死亡率增加以及生活质量下降有关。一个
这种脑损伤的潜在原因可能是大脑动脉的完整性受损;然而,动脉的状态
完整性及其与脑损伤和认知的关系在CHD中尚未见报道。信息来自
这项研究有可能揭示CHD脑损伤的一个过程。因此,它具有重要的
脑动脉完整性修复术对冠心病有效治疗的意义
其他情况(如中风和创伤性脑损伤),可以显著改善认知能力
在这一高危患者群体中,改善其功能,降低死亡率和发病率,提高生活质量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rajesh Kumar其他文献
Rajesh Kumar的其他文献
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{{ truncateString('Rajesh Kumar', 18)}}的其他基金
Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting- A Randomized Clinical Trial
接受冠状动脉搭桥术的老年人的硫胺素干预和认知——一项随机临床试验
- 批准号:
10811014 - 财政年份:2023
- 资助金额:
$ 50.2万 - 项目类别:
Brain Metabolites, Brain Antioxidant, and Cerebral Blood Flow Deficits in Single Ventricle Heart Disease
单心室心脏病中的脑代谢物、脑抗氧化剂和脑血流缺陷
- 批准号:
10644553 - 财政年份:2023
- 资助金额:
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Brain Changes in Pediatric Obstructive Sleep Apnea
小儿阻塞性睡眠呼吸暂停的大脑变化
- 批准号:
10468277 - 财政年份:2021
- 资助金额:
$ 50.2万 - 项目类别:
Brain Changes in Pediatric Obstructive Sleep Apnea
小儿阻塞性睡眠呼吸暂停的大脑变化
- 批准号:
10218463 - 财政年份:2021
- 资助金额:
$ 50.2万 - 项目类别:
Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart Disease
脑动脉完整性与先天性心脏病的脑损伤和认知有关
- 批准号:
9337504 - 财政年份:2016
- 资助金额:
$ 50.2万 - 项目类别:
Blood-Brain Barrier Deficit and Brain Injury in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停中的血脑屏障缺陷和脑损伤
- 批准号:
8887911 - 财政年份:2015
- 资助金额:
$ 50.2万 - 项目类别:
Blood-Brain Barrier Deficit and Brain Injury in Obstructive Sleep Apnea
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- 批准号:
9038446 - 财政年份:2015
- 资助金额:
$ 50.2万 - 项目类别:
Blood-Brain Barrier Dysfunction and Brain Injury in Heart Failure
心力衰竭时的血脑屏障功能障碍和脑损伤
- 批准号:
9297116 - 财政年份:2014
- 资助金额:
$ 50.2万 - 项目类别:
Blood-Brain Barrier Dysfunction and Brain Injury in Heart Failure
心力衰竭时的血脑屏障功能障碍和脑损伤
- 批准号:
8926474 - 财政年份:2014
- 资助金额:
$ 50.2万 - 项目类别:
Brain Axonal Injury in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停引起的脑轴突损伤
- 批准号:
8692590 - 财政年份:2012
- 资助金额:
$ 50.2万 - 项目类别:
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