Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart Disease

脑动脉完整性与先天性心脏病的脑损伤和认知有关

基本信息

  • 批准号:
    9337504
  • 负责人:
  • 金额:
    $ 49.57万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-01 至 2020-05-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ ABSTRACT Adolescents with congenital heart disease (CHD) show brain injury in regions (hippocampus, frontal cortex, temporal, and parietal), which control cognition. Abnormalities in these sites are associated with cognitive deficits. However, the underlying cause of brain injury in these areas in CHD is unclear. Alteration in cerebral artery integrity (measured by arterial transit time [ATT]), which is associated with neural injury in other diseases, is a potential cause of brain injury in CHD. However, there are no published reports of cerebral artery integrity in CHD or regarding any associations between cerebral artery integrity, brain injury, and cognition in this condition. We will use a comparative study design, 80 subjects (40 CHD / 40 Healthy controls), with inclusion criteria for CHD will be subjects between 14-18 years of age, have undergone surgical repair or palliation, and controls will be age- and gender-matched to CHD subjects. Using non-invasive brain magnetic resonance imaging (MRI) procedures, our preliminary study is the first to report abnormalities in ATT values (via diffusion-weighted pseudo-continuous arterial spin labeling [pCASL] procedures) in CHD and that these changes are associated with brain injury (as examined by diffusion tensor imaging based mean diffusivity [MD], an MRI measure of tissue integrity) in the hippocampus, frontal cortex, temporal, and parietal regions in CHD subjects compared to controls. However, while promising, the sample size in this preliminary study was quite small and did not allow us to control for important covariates, such as age and gender. Therefore, the specific aims of this proposal are to: 1) compare ATT values (calculated from diffusion-weighted pCASL) between CHD and age- and gender-matched control subjects; 2) compare regional MD values, derived from diffusion tensor imaging data and cognitive scores (measured by the total Montreal Assessment of Cognition [MoCA] and general memory index (GMI) score from the Wide Range Assessment of Memory and Learning [WRAML2]) between CHD and age- and gender-matched control subjects; 3) examine the relationships between altered ATT (indicating cerebral artery integrity), regional MD values (assessment of injury), and cognitive scores in CHD patients. In summary, CHD patients show significant brain injury in areas that control cognition. These deficits are associated with poor school performance, increased morbidity and mortality, and poorer quality of life. A potential cause of this brain injury may be compromised cerebral artery integrity; however, status of the artery integrity and its association with brain injury and cognition has not been reported in CHD. Information from this study has the potential to disclose a process contributing to brain injury in CHD. Thus, it has important implications on identification of effective treatments for CHD by repairing cerebral artery integrity as used in other conditions (such as stroke and traumatic brain injury), which could dramatically improve cognitive function, reduce mortality and morbidity, and increase quality of life in this high risk patient population.
项目摘要/摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Rajesh Kumar其他文献

Rajesh Kumar的其他文献

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{{ truncateString('Rajesh Kumar', 18)}}的其他基金

Brain Metabolites, Brain Antioxidant, and Cerebral Blood Flow Deficits in Single Ventricle Heart Disease
单心室心脏病中的脑代谢物、脑抗氧化剂和脑血流缺陷
  • 批准号:
    10644553
  • 财政年份:
    2023
  • 资助金额:
    $ 49.57万
  • 项目类别:
Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting- A Randomized Clinical Trial
接受冠状动脉搭桥术的老年人的硫胺素干预和认知——一项随机临床试验
  • 批准号:
    10811014
  • 财政年份:
    2023
  • 资助金额:
    $ 49.57万
  • 项目类别:
Brain Changes in Pediatric Obstructive Sleep Apnea
小儿阻塞性睡眠呼吸暂停的大脑变化
  • 批准号:
    10468277
  • 财政年份:
    2021
  • 资助金额:
    $ 49.57万
  • 项目类别:
Brain Changes in Pediatric Obstructive Sleep Apnea
小儿阻塞性睡眠呼吸暂停的大脑变化
  • 批准号:
    10218463
  • 财政年份:
    2021
  • 资助金额:
    $ 49.57万
  • 项目类别:
Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart Disease
脑动脉完整性与先天性心脏病的脑损伤和认知有关
  • 批准号:
    9157665
  • 财政年份:
    2016
  • 资助金额:
    $ 49.57万
  • 项目类别:
Blood-Brain Barrier Deficit and Brain Injury in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停中的血脑屏障缺陷和脑损伤
  • 批准号:
    8887911
  • 财政年份:
    2015
  • 资助金额:
    $ 49.57万
  • 项目类别:
Blood-Brain Barrier Deficit and Brain Injury in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停中的血脑屏障缺陷和脑损伤
  • 批准号:
    9038446
  • 财政年份:
    2015
  • 资助金额:
    $ 49.57万
  • 项目类别:
Blood-Brain Barrier Dysfunction and Brain Injury in Heart Failure
心力衰竭时的血脑屏障功能障碍和脑损伤
  • 批准号:
    9297116
  • 财政年份:
    2014
  • 资助金额:
    $ 49.57万
  • 项目类别:
Blood-Brain Barrier Dysfunction and Brain Injury in Heart Failure
心力衰竭时的血脑屏障功能障碍和脑损伤
  • 批准号:
    8926474
  • 财政年份:
    2014
  • 资助金额:
    $ 49.57万
  • 项目类别:
Brain Axonal Injury in Obstructive Sleep Apnea
阻塞性睡眠呼吸暂停引起的脑轴突损伤
  • 批准号:
    8692590
  • 财政年份:
    2012
  • 资助金额:
    $ 49.57万
  • 项目类别:

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