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Role of human cervical mucus plugs in ascending GBS infection

人类宫颈粘液塞在 GBS 上行感染中的作用

基本信息

批准号：
9303886
负责人：
Lakshmi Rajagopal
金额：
$ 23.37万
依托单位：
SEATTLE CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-24 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9303886
关键词：
Accounting Acids Adult Amniotic Fluid Anabolism Anti-Bacterial Agents Bacteria Bacterial Genes Bacterial Infections Cervical Cervix Mucus Cystatins Data Defensins Development Event Fetus Gene Expression Gene Proteins Genes Genetic Transcription Global Change Goals Gram-Positive Bacteria Growth Growth Factor Human Infection Injury Integration Host Factors Lactoferrin Leukocyte L1 Antigen Complex Microbe Morbidity - disease rate Mucous body substance Muramidase Nature Neonatal Neonatal Mortality Newborn Infant Organism Peptide Hydrolases Peptides Permeability Plug-in Predisposition Pregnancy Pregnant Women Premature Birth Premature Labor Prevention Property Protein Secretion Proteins Public Health Recovery Reporting Role Serotyping Signal Transduction Streptococcal Infections Streptococcus Group B Supplementation Symbiosis Therapeutic Toxic effect Ureaplasma Uterus Vagina Virulence Factors Woman amniotic cavity antileukoprotease antimicrobial antimicrobial drug antimicrobial peptide capsule clinically significant early onset effective therapy fetal human mortality in utero insight intraamniotic infection microbial microorganism neonatal morbidity novel pathogen placental membrane prevent reproductive tract resistance mechanism risk minimization stillbirth transmission process

项目摘要

PROJECT SUMMARY Bacterial infections leading to morbidity and mortality of human newborns remain significant public health concerns. Group B Streptococci (GBS) are Gram-positive bacteria that cause preterm births, stillbirths and early onset infections in human newborns. Although GBS normally reside as commensal organisms in the lower genital tract (LGT) of healthy women, the events that promote transmission of GBS from the LGT to the amniotic cavity and fetus during pregnancy are unknown. The objective of this proposal is to define the role of the human cervical mucus plug in prevention of GBS growth and to determine if GBS sense CMP and modify virulence factor expression leading to ascending infection and fetal injury.

项目摘要导致人类新生儿发病和死亡的细菌感染仍然是重大的公共卫生问题性问题B族链球菌（GBS）是革兰氏阳性菌，可导致早产、死胎和人类新生儿的早期感染。虽然GBS通常作为浮游生物存在于健康女性的下生殖道（LGT），促进GBS从LGT传播到妊娠期间羊膜腔和胎儿未知。本提案的目的是界定人宫颈粘液栓在预防GBS生长中的作用，并确定GBS是否能感知CMP 并改变毒力因子的表达，导致上行感染和胎儿损伤。