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Role of an ornithine rhamnolipid pigment in GBS virulence

鸟氨酸鼠李糖脂色素在 GBS 毒力中的作用

基本信息

批准号：
9097532
负责人：
Lakshmi Rajagopal
金额：
$ 49.12万
依托单位：
SEATTLE CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9097532
关键词：
Affect Age Antibiotic Prophylaxis Antibodies Bacillus cereus Bacterial Infections Biochemical Biological Burkholderia pseudomallei Cells Cerebral Palsy Clinical Communicable Diseases Cytolysis Data Disease Environment Epithelial Cells Erythrocytes Eukaryotic Cell Future Generations Genes Gram-Positive Bacteria Health Human Immune response Infant Infection Inflammatory Response Interleukin-1 Late-Onset Disorder Lipid Bilayers Lipids Low Birth Weight Infant Lung Measures Mediating Mediator of activation protein Membrane Meningitis Mental Retardation Molecular Morbidity - disease rate Mus Neurologic Newborn Infant Organism Ornithine Pathogenesis Penetration Perinatal Peritoneal Pigments Placenta Pneumonia Premature Birth Premature Labor Prevention strategy Proteins Pseudomonas aeruginosa Public Health Reactive Oxygen Species Reporting Role Seizures Sepsis Streptococcal Infections Streptococcus Group B Streptococcus pneumoniae TNF gene Tissues Toxin Transgenic Organisms Uterine Contraction Vagina Virulence Virulence Factors Woman Work amniotic cavity analog base brain endothelial cell chemical synthesis cytokine cytotoxic early onset human mortality in utero insight intrapartum macrophage mast cell mortality novel pathogen prevent reproductive tract response rhamnolipid stillbirth therapeutic development vaginal fluid

项目摘要

DESCRIPTION (provided by applicant): Morbidity and mortality of human newborns remain significant public health concerns. Streptococcus agalactiae or Group B Streptococcus (GBS) cause invasive infections such as pneumonia, sepsis and meningitis in human newborns. Moreover, GBS are a significant cause of in utero infections leading to preterm births and stillbirths. We recently showed that the pluripotent toxin important for GBS infections is an ornithine rhamnolipid pigment also known as granadaene. The pigment/lipid toxin is cytotoxic to a number of host cells and induces a proinflammatory immune response. The objective of this proposal is to understand how the pigment causes host cell lysis and induces an immune response and to also define how pigment mediated activation of host cells affects GBS colonization and infection-associated preterm births.

描述（由申请人提供）：人类新生儿的发病率和死亡率仍然是重大的公共卫生问题。无乳链球菌或 B 族链球菌 (GBS) 会引起人类新生儿的侵袭性感染，例如肺炎、败血症和脑膜炎。此外，GBS 是导致早产和死产的子宫内感染的重要原因。我们最近发现，对 GBS 感染很重要的多能毒素是鸟氨酸鼠李糖脂色素，也称为格拉纳达烯。色素/脂质毒素对许多宿主细胞具有细胞毒性，并诱导促炎性免疫反应。该提案的目的是了解色素如何引起宿主细胞裂解并诱导免疫反应，并确定色素介导的宿主细胞激活如何影响 GBS 定植和感染相关的早产。