鸟氨酸鼠李糖脂色素在 GBS 毒力中的作用-猫眼课题宝

鸟氨酸鼠李糖脂色素在 GBS 毒力中的作用

批准号：

9097532

负责人：

Lakshmi Rajagopal

金额：

$49.12万

依托单位：

SEATTLE CHILDREN'S HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

2014

资助国家：

美国

项目状态：

已结题

起止时间：

2014-07-01 至 2019-06-30

来源：

https://reporter.nih.gov/project-details/9097532

关键词：

Affect Age Antibiotic Prophylaxis Antibodies Bacillus cereus Bacterial Infections Biochemical Biological Burkholderia pseudomallei Cells Cerebral Palsy Clinical Communicable Diseases Cytolysis Data Disease Environment Epithelial Cells Erythrocytes Eukaryotic Cell Future Generations Genes Gram-Positive Bacteria Health Human Immune response Infant Infection Inflammatory Response Interleukin-1 Late-Onset Disorder Lipid Bilayers Lipids Low Birth Weight Infant Lung Measures Mediating Mediator of activation protein Membrane Meningitis Mental Retardation Molecular Morbidity - disease rate Mus Neurologic Newborn Infant Organism Ornithine Pathogenesis Penetration Perinatal Peritoneal Pigments Placenta Pneumonia Premature Birth Premature Labor Prevention strategy Proteins Pseudomonas aeruginosa Public Health Reactive Oxygen Species Reporting Role Seizures Sepsis Streptococcal Infections Streptococcus Group B Streptococcus pneumoniae TNF gene Tissues Toxin Transgenic Organisms Uterine Contraction Vagina Virulence Virulence Factors Woman Work amniotic cavity analog base brain endothelial cell chemical synthesis cytokine cytotoxic early onset human mortality in utero insight intrapartum macrophage mast cell mortality novel pathogen prevent reproductive tract response rhamnolipid stillbirth therapeutic development vaginal fluid

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中文摘要

翻译

描述(由申请人提供)：人类新生儿的发病率和死亡率仍然是严重的公共卫生问题。无乳链球菌或B组链球菌(GBS)可引起新生儿的侵袭性感染，如肺炎、败血症和脑膜炎。此外，GBS是导致早产和死产的宫内感染的重要原因。我们最近发现，对GBS感染重要的多能性毒素是一种鸟氨酸鼠李糖脂色素，也被称为石榴糖烯。色素/脂类毒素对许多宿主细胞具有细胞毒性，并诱导促炎免疫反应。这个建议的目的是了解色素如何引起宿主细胞裂解和诱导免疫反应，并确定色素介导的宿主细胞激活如何影响GBS的定植和感染相关的早产。

英文摘要

DESCRIPTION (provided by applicant): Morbidity and mortality of human newborns remain significant public health concerns. Streptococcus agalactiae or Group B Streptococcus (GBS) cause invasive infections such as pneumonia, sepsis and meningitis in human newborns. Moreover, GBS are a significant cause of in utero infections leading to preterm births and stillbirths. We recently showed that the pluripotent toxin important for GBS infections is an ornithine rhamnolipid pigment also known as granadaene. The pigment/lipid toxin is cytotoxic to a number of host cells and induces a proinflammatory immune response. The objective of this proposal is to understand how the pigment causes host cell lysis and induces an immune response and to also define how pigment mediated activation of host cells affects GBS colonization and infection-associated preterm births.

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