Project 3- An MRI Study of the Effects of Prenatal and Early Childhood PAH Exposure on Brain Maturation and Its Mediating Influences on Adverse Adolescent Outcomes

项目 3 - 产前和儿童早期 PAH 暴露对大脑成熟的影响及其对青少年不良后果的中介影响的 MRI 研究

• 批准号: 9341300
• 负责人: BRADLEY S PETERSON
• 金额: $ 12.73万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9341300
• 关键词: 12 year old; 17 year old; 9 year old; Address; Adolescence; Adolescent; Adverse effects; Affect; African American; Age; Alcohol or Other Drugs use; Anatomy; Aromatic Polycyclic Hydrocarbons; Attention deficit hyperactivity disorder; Base of the Brain; Behavior; Behavioral; Biological; Birth; Brain; Cell Nucleus; Child; Childhood; Cognitive; Data Set; Development; Diffusion Magnetic Resonance Imaging; Education; Emotional; Emotions; Environmental Health; Environmental Impact; Exposure to; Failure; Funding; Future; Health; Health Policy; Image; Impairment; Individual; Informal Social Control; Intervention; Knowledge; Latino; Left cerebral hemisphere; Life; Link; Low income; MRI Scans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Mediating; Mental Depression; Metabolic; Metabolism; N-acetylaspartate; Neuronal Plasticity; Neurons; New York City; Obesity; Outcome; Parietal; Perfusion; Pilot Projects; Policies; Population; Problem behavior; Process; Rest; Scanning; Source; Structure; Support System; Symptoms; System; Temporal Lobe; Therapeutic Intervention; Time; Toxic Environmental Substances; Translating; base; cohort; early childhood; experience; high risk; high risk behavior; imaging study; indexing; neurobehavioral; neurodevelopment; pesticide exposure; postnatal; preadolescence; prenatal; prenatal exposure; relating to nervous system; resilience; social; targeted treatment; therapeutic development; therapy development; tobacco exposure; vulnerable adolescent; white matter

Project Summary: The Columbia Center for Children’s Environmental Health (CCCEH) has followed a birth cohort of low-income, African-American and Latino children in New York City into their pre-adolescent years to assess the impact of environmental toxicants on health and development. In a pilot study of MRI measures in 40 of these children at 7-9 years of age, we identified abnormalities in anatomical measures of white matter throughout the entire left cerebral hemisphere that were linearly associated with prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAH). Those white matter abnormalities were in turn linearly associated with measures of cognitive, emotional, behavioral, and adiposity (CEBA) problems at the time of MRI scan. Under separate funding, we have collected brain-based MRI measures and neurobehavioral outcomes in 350 preadolescent children of the CCCEH cohort, between 9 and 12 years of age. The MRI dataset in 9-12 year olds includes state-of-the-art measures of brain structure (anatomical MRI), function (functional MRI), anatomical connectivity and white matter integrity (Diffusion Tensor Imaging, or DTI), and neurometabolite concentrations (MR Spectroscopy, or MRS); we will now evaluate the effects of prenatal and early postnatal exposure to PAH on each of those measures of brain structure, function, and metabolism at age 9-12 (preadolescence), and how the PAH-related disturbances in brain measures mediate CEBA outcomes at age 15-17 (in adolescence -- outcomes that are being assessed in Projects 1 & 2). In addition, we will acquire new anatomical MRI scans at 15-17 years of age (adolescence) in this same cohort to assess the correlations of early PAH exposure with measures of brain structure in adolescence. The new anatomical MRI scans, together with the anatomical scans already collected in preadolescence at ages 9-12, will allow us to assess whether early exposure to high levels of PAH significantly disrupt the normal changes in brain structure within self- regulatory systems from childhood through adolescence, and whether those children with the most disrupted anatomical changes experience the greatest degree of conduct disturbances, substance use, and depression, persistent ADHD symptoms, and adiposity measures, at 15-17 years of age. This information will help us understand whether the adverse organizational effects of early life PAH exposure continue to derail brain development later in life, or whether any compensatory neuroplastic effects occur during this time of transition that help to mitigate those adverse effects. This knowledge can be translated to education and policy and exploited to aid the future development of therapeutic interventions.

项目摘要：哥伦比亚儿童环境健康中心（CCCEH）出生了 纽约市低收入，非洲裔美国人和拉丁裔儿童的队列进入他们的青春期前几年 评估环境有毒物质对健康和发展的影响。在一项对MRI测量的试点研究中 在7-9岁的这些儿童中，有40岁，我们确定了白质解剖学措施的异常 在整个左脑半球中，与产前暴露于空中 多环芳烃（PAH）。这些白质异常又与 MRI扫描时的认知，情感，行为和肥胖（CEBA）问题的度量。在下面 单独的资金，我们收集了350的基于大脑的MRI测量和神经行为结果 CCCEH队列的青春期前子女在9至12岁之间。 9 - 12年的MRI数据集 老年人包括大脑结构（解剖学MRI），功能（功能性MRI）的最新测量。 解剖连通性和白质完整性（扩散张量成像或DTI）和神经代谢物 浓度（MR光谱法或MRS）；现在，我们将评估产前和早期产后的影响 9-12岁的大脑结构，功能和新陈代谢的每种措施中的PAH暴露于PAH （前），以及与PAH相关的灾难如何介导CEBA的结局 15-17（在青少年 - 在项目1和2中评估的结果）。此外，我们将获得新的 在同一队列中的15-17岁（青春期）的解剖学MRI扫描以评估相关性 早期的PAH暴露在青春期中的大脑结构测量。新的解剖学MRI扫描，一起 随着9-12岁的Preadamelmencen中已经收集的解剖学扫描，将使我们能够评估是否是否 早期暴露于高水平的PAH会显着破坏自我内部大脑结构的正常变化 从童年到青少年的监管系统，以及那些受最干扰的孩子是否 解剖学变化经历了最大程度的行为灾难，药物使用和抑郁症， 15-17岁的持续性多动症症状和肥胖度量。 这些信息将有助于我们了解早期生命的不利组织影响PAH暴露的影响是否 继续生命后来继续破坏大脑的发育，或者是否发生任何补偿性神经塑性作用 在过渡时期，有助于减轻这些不利影响。这些知识可以转化为 教育和政策，并探索以帮助未来的治疗干预措施发展。