19th and 20th International Symposium on Cells of the Hepatic Sinusoid to be held in 2017 in Galway, Ireland and 2019 in Sydney, Australia.

摘要 此R13应用程序请求支持第19届和第20届国际肝细胞研讨会 正弦(ISCHS)将于2017年6月在爱尔兰戈尔韦和2019年6月在澳大利亚悉尼举行。这个 应用程序请求支持特邀专家演讲者的参与，以及年轻的临床和 基础调查员。ISCHS的目标是汇聚一个多学科的国际组织 科学家，包括现有和新的研究人员，以及博士后和博士后实习生，他们是 对常见的问题感兴趣：“不同类型的肝细胞之间的相互作用是如何在肝脏 肝窦有助于肝脏的发育和生长、体内平衡和疾病的病理结果？“ 会议的参与者将展示尖端的、高质量的研究，这些研究开始识别新的 肝窦内的分子和细胞相互作用。我们对……的理解存在着惊人的差距。 这是肝脏功能活动的基本单位；肝窦细胞生物学的进展对 了解酒精性肝病(ALD)的细胞基础。ISCHS代表了唯一的国际 该组织聚集了来自世界各地的肝脏生物学和肝细胞相关领域的主要研究人员 世界。这次会议将促进和促进：1)不同国家之间的国际合作 患有肌萎缩侧索硬化症的遗传和社会背景不同的人群，2)资源共享 在国际调查人员之间，产生协同作用和独特的想法，以及3)受训人员在 国际水平。综上所述，ISCHS独特的环境是尖端技术的理想模式 他们对ALD发病机制研究的潜在意义上的相互作用，有助于协同 将填补这些空白并推动ALD研究和预防性开发的前沿的研究 和治疗性治疗。

ABSTRACT This R13 application requests support for the 19th and 20th International Symposium on Cells of the Hepatic Sinusoid (ISCHS) to be held in Galway, Ireland in June 2017 and Sydney, Australia in June 2019. The application requests support for the participation of invited expert speakers, as well as for young clinical and basic investigators. The goal of the ISCHS is to bring together an international group of multidisciplinary scientists, including established and new investigators, as well as pre- and post-doctoral trainees, who are interested in the common questions: “How does the cross-talk between different liver cell types in the hepatic sinusoid facilitate liver development and growth, homeostasis and pathological outcomes in disease?”. Participants at the meeting will present cutting edge, high quality research which begins to identify novel molecular and cellular interactions within the liver sinusoid. There are surprising gaps in our understanding of this basic unit of functional activity in the liver; advances in hepatic sinusoidal cell biology are critical to understanding the cellular basis of alcoholic liver disease (ALD). The ISCHS represents the only international organization which gathers leading investigators in liver biology and hepatocellular cross talk from around the world. This meeting will facilitate and promote: 1) international collaborations between different countries with populations differing in their genetics and social backgrounds who suffer from ALD, 2) resource sharing between international investigators, generating synergy and unique ideas and 3) interaction of trainees at the international level. Taken together, the unique environment of the ISCHS is an ideal format for cutting-edge interactions on the potential implications of their research into the pathogenesis of ALD, helping to synergize research that will fill these gaps and advance the frontier of research in ALD and development of preventative and therapeutic treatments.