19th and 20th International Symposium on Cells of the Hepatic Sinusoid to be held in 2017 in Galway, Ireland and 2019 in Sydney, Australia.

摘要 此R13应用程序请求支持第19届和第20届国际肝细胞研讨会 Sinusoid（ISCHS）将于2017年6月在爱尔兰的高威和2019年6月在澳大利亚的悉尼举行。的 申请要求支持受邀专家演讲者的参与，以及年轻的临床和 基本调查员。ISCHS的目标是汇集一个多学科的国际小组， 科学家，包括已建立和新的研究人员，以及前和博士后学员，谁是 感兴趣的常见问题：“如何在肝脏中不同的肝细胞类型之间的串扰， 血窦促进肝脏发育和生长，体内平衡和疾病的病理结果？ 与会者将提出尖端，高质量的研究，开始确定新的 肝窦内的分子和细胞相互作用。在我们的理解中存在着令人惊讶的差距 肝窦细胞是肝脏功能活动的基本单位;肝窦细胞生物学的进展对于 了解酒精性肝病（ALD）的细胞基础。ISCHS代表了唯一的国际 该组织聚集了来自世界各地的肝脏生物学和肝细胞串扰方面的领先研究人员， 世界本次会议将促进和推动：1）不同国家之间的国际合作， 遗传和社会背景不同的ALD患者，2）资源共享 国际调查人员之间的互动，产生协同作用和独特的想法，3）学员在 国际一级。总的来说，ISCHS的独特环境是一个理想的格式， 相互作用的潜在影响，他们的研究到ALD的发病机制，有助于协同 研究，将填补这些空白，并推进ALD研究的前沿和预防性药物的开发， 和治疗性治疗。

ABSTRACT This R13 application requests support for the 19th and 20th International Symposium on Cells of the Hepatic Sinusoid (ISCHS) to be held in Galway, Ireland in June 2017 and Sydney, Australia in June 2019. The application requests support for the participation of invited expert speakers, as well as for young clinical and basic investigators. The goal of the ISCHS is to bring together an international group of multidisciplinary scientists, including established and new investigators, as well as pre- and post-doctoral trainees, who are interested in the common questions: “How does the cross-talk between different liver cell types in the hepatic sinusoid facilitate liver development and growth, homeostasis and pathological outcomes in disease?”. Participants at the meeting will present cutting edge, high quality research which begins to identify novel molecular and cellular interactions within the liver sinusoid. There are surprising gaps in our understanding of this basic unit of functional activity in the liver; advances in hepatic sinusoidal cell biology are critical to understanding the cellular basis of alcoholic liver disease (ALD). The ISCHS represents the only international organization which gathers leading investigators in liver biology and hepatocellular cross talk from around the world. This meeting will facilitate and promote: 1) international collaborations between different countries with populations differing in their genetics and social backgrounds who suffer from ALD, 2) resource sharing between international investigators, generating synergy and unique ideas and 3) interaction of trainees at the international level. Taken together, the unique environment of the ISCHS is an ideal format for cutting-edge interactions on the potential implications of their research into the pathogenesis of ALD, helping to synergize research that will fill these gaps and advance the frontier of research in ALD and development of preventative and therapeutic treatments.