CSHL Cellular Biology of Addiction Course

 描述（由申请人提供）：药物成瘾是我们国家面临的最昂贵的神经精神疾病。急性和反复暴露于药物产生神经适应和长期记忆的经验，但涉及的细胞和分子过程只有部分了解。拟议的讲座和讨论课程的主要目标是提供一个基本的，国家的最先进的进展和药物成瘾的细胞和分子生物学的主要差距激烈的讨论。针对新的和有经验的调查人员，该课程将结合联合收割机正式介绍和非正式讨论，以传达药物成瘾研究的细胞和分子方法的优点和兴奋。随着基因组学和蛋白质组学的出现，现在存在一个非凡的机会来开发神经适应过程的综合模型，这些过程对成瘾、戒断、渴望和药物使用复发以及大脑功能至关重要。一系列学科和主题将被代表，包括非侵入性脑成像，以确定药物靶点和适应过程;在分子和细胞水平的神经适应过程，神经网络及其调制，基因型易感性和药物反应的相关性;在细胞水平的耐受性和适应性，以及利用神经信息学产生的令人生畏的数量的方法。本课程将提供对成瘾的神经适应性反应的当前和新研究的综合观点，促进对协作和整合的讨论，提供构建成瘾作为疾病和生物治疗新分子靶点的模型所需的关键信息。在科学奋进之外，这些信息对于制定公共政策和启发公众了解药物使用和成瘾的神经生物学后果至关重要。该课程旨在引起对这种分析水平的兴趣，为合作开辟渠道，并提出研究成瘾药物神经生物学的新途径。该课程尽一切努力包括一个多元化的参与者群体，特别注意包括妇女，美国少数民族和国家和国际科学家的良好平衡。该课程在培养和留住神经生物学特别是成瘾研究方面的年轻科学家方面有着良好的记录。最后，CSHL开发了各种机制，通过使用YouTube和类似网站上提供的公开访问讲座视频档案，向更广泛的受众传播科学专题介绍。

 DESCRIPTION (provided by applicant): Drug addiction is the most costly neuropsychiatric disorder faced by our nation. Acute and repeated exposure to drugs produces neuroadaption and long-term memory of the experience, but the cellular and molecular processes involved are only partially understood. The primary objective of the proposed lecture-and-discussion course is to provide an intense discussion of the fundamentals, state-of-the-art advances and major gaps in the cell and molecular biology of drug addiction. Targeted to both new and experienced investigators, the course will combine formal presentations and informal discussions to convey the merits and excitement of cellular and molecular approaches to drug addiction research. With the advent of genomics and proteomics, an extraordinary opportunity now exists to develop comprehensive models of neuroadaptative processes fundamental to addiction, withdrawal, craving, and relapse to drug use and to brain function, in general. A range of disciplines and topics will be represented, including noninvasive brain imaging to identify drug targets and adaptive processes; neuroadaptative processes at the molecular and cellular level, neural networks and their modulation, the relevance of genotype to susceptibility and drug response; tolerance and adaptation at the cellular level and approaches to exploiting the daunting volume generated by neuroinformatics. This course will provide an integrated view of current and novel research on neuroadaptive responses to addiction, foster discussion on collaboration and integration, provide critical information needed to construct a model of addiction as a disease and novel molecular targets for biological treatments. Beyond the plane of scientific endeavor, the information is vital for formulating public policy and for enlightening the public on the neurobiological consequences of drug use and addiction. The course designed to generate interest in this level of analysis, open conduits for collaborations and present novel routes to investigating the neurobiology of addictive drugs. The course makes every effort to include a diverse group of participants, being particularly mindful of the inclusion of women, US minorities and a good balance of national and international scientists. The course has an excellent track record of training and retaining young scientists in neurobiological and specifically in addiction research. Finally, CSHL has developed mechanisms for dissemination of the scientific presentations to a broader audience through the use of open access video archives of the lectures available on YouTube and similar sites.