CSHL Cellular Biology of Addiction Course

CSHL 成瘾细胞生物学课程

• 批准号: 9315774
• 负责人: DAVID J. STEWART
• 金额: $ 5.13万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9315774
• 关键词: Acute; Archives; Attention; Behavioral; Biological Neural Networks; Biological Response Modifier Therapy; Brain; Brain imaging; Cells; Cellular biology; Collaborations; Discipline; Disease; Disease model; Drug Addiction; Drug Targeting; Drug abuse; Drug usage; Effectiveness; Electronic Mail; Emerging Technologies; Ensure; Environment Design; Equilibrium; Evaluation; Exposure to; Faculty; Fostering; Foundations; Future; Genes; Genomics; Genotype; Human Genome; Individual; International; Lead; Learning; Measures; Memory; Mentors; Minority; Modeling; Molecular; Molecular Biology; Molecular Genetics; Molecular Target; Neurobiology; Neurosciences; New York; Online Systems; Participant; Perception; Pharmaceutical Preparations; Physiological; Predisposition; Process; Proteomics; Public Policy; Publications; Relapse; Research; Research Personnel; Retreatment; Route; Scientist; Site; Stress; Structure; Students; Substance Addiction; Substance abuse problem; Suggestion; Surveys; Techniques; Tissues; Training; Universities; Walking; Withdrawal; Woman; addiction; behavioral study; college; cost; craving; design; drug development; drug discovery; drug of abuse; experience; instructor; interdisciplinary approach; interest; lecturer; lectures; long term memory; mindfulness; neuroadaptation; neuroinformatics; neuropsychiatric disorder; new technology; north shore long island; novel; present value; programs; public health relevance; rapid growth; receptor; response; satisfaction; symposium

 DESCRIPTION (provided by applicant): Drug addiction is the most costly neuropsychiatric disorder faced by our nation. Acute and repeated exposure to drugs produces neuroadaption and long-term memory of the experience, but the cellular and molecular processes involved are only partially understood. The primary objective of the proposed lecture-and-discussion course is to provide an intense discussion of the fundamentals, state-of-the-art advances and major gaps in the cell and molecular biology of drug addiction. Targeted to both new and experienced investigators, the course will combine formal presentations and informal discussions to convey the merits and excitement of cellular and molecular approaches to drug addiction research. With the advent of genomics and proteomics, an extraordinary opportunity now exists to develop comprehensive models of neuroadaptative processes fundamental to addiction, withdrawal, craving, and relapse to drug use and to brain function, in general. A range of disciplines and topics will be represented, including noninvasive brain imaging to identify drug targets and adaptive processes; neuroadaptative processes at the molecular and cellular level, neural networks and their modulation, the relevance of genotype to susceptibility and drug response; tolerance and adaptation at the cellular level and approaches to exploiting the daunting volume generated by neuroinformatics. This course will provide an integrated view of current and novel research on neuroadaptive responses to addiction, foster discussion on collaboration and integration, provide critical information needed to construct a model of addiction as a disease and novel molecular targets for biological treatments. Beyond the plane of scientific endeavor, the information is vital for formulating public policy and for enlightening the public on the neurobiological consequences of drug use and addiction. The course designed to generate interest in this level of analysis, open conduits for collaborations and present novel routes to investigating the neurobiology of addictive drugs. The course makes every effort to include a diverse group of participants, being particularly mindful of the inclusion of women, US minorities and a good balance of national and international scientists. The course has an excellent track record of training and retaining young scientists in neurobiological and specifically in addiction research. Finally, CSHL has developed mechanisms for dissemination of the scientific presentations to a broader audience through the use of open access video archives of the lectures available on YouTube and similar sites.

 描述（由申请人提供）：吸毒成瘾是我们国家面临的最昂贵的神经精神疾病。急性和反复接触药物会产生神经适应和对体验的长期记忆，但所涉及的细胞和分子过程仅被部分了解。拟议的讲座和讨论课程的主要目的是对药物成瘾的细胞和分子生物学的基础知识、最新进展和主要差距进行深入讨论。该课程针对新的和经验丰富的研究人员，将结合正式的演示和非正式的讨论，以传达细胞和分子方法在药物成瘾研究中的优点和令人兴奋的内容。随着基因组学和蛋白质组学的出现，现在存在一个绝佳的机会来开发神经适应过程的综合模型，这些模型对于成瘾、戒断、渴望、药物滥用和大脑功能的复发至关重要。将代表一系列学科和主题，包括用于识别药物靶点和适应性过程的无创脑成像；分子和细胞水平的神经适应过程、神经网络及其调节、基因型与易感性和药物反应的相关性；细胞水平的耐受性和适应以及利用神经信息学产生的令人畏惧的体积的方法。本课程将提供对成瘾神经适应性反应的当前和新颖研究的综合看法，促进关于合作和整合的讨论，提供构建成瘾疾病模型所需的关键信息以及生物治疗的新分子靶点。除了科学努力之外，这些信息对于制定公共政策和启发公众了解吸毒和成瘾的神经生物学后果也至关重要。该课程旨在激发人们对这种水平的分析的兴趣，开辟合作渠道，并提出研究成瘾药物神经生物学的新途径。该课程尽一切努力吸引多元化的参与者，特别注意女性、美国少数族裔以及国内和国际科学家的良好平衡。该课程在神经生物学，特别是成瘾研究领域培训和留住年轻科学家方面有着出色的记录。最后，CSHL 开发了通过使用 YouTube 和类似网站上的开放获取讲座视频档案向更广泛的受众传播科学演示的机制。