Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome

摘要 鉴于精神疾病的高患病率和对智障人士的重大影响 (ID)检查智障者心理健康状况的研究对于旨在减少的直接治疗至关重要 更重要的是，预防精神疾病，以改善功能和生活质量。脆性X 综合征(FXS)是导致ID的主要原因，高达80%的青少年和成年人患有FXS 符合焦虑症的标准。FXS是研究组合和交互的理想模型 生物、行为和环境因素对人焦虑显现轨迹的影响 这个名为“脆性X综合征焦虑的出现、稳定性和预测因素”的应用程序提出了 FXS男童早期焦虑特征的首次纵向前瞻性发展研究 与被诊断为ASD的男孩(非FXS)和典型对照组(TD)进行对比。我们对这个年代很感兴趣 焦虑的最初特征可以被检测到，这些早期症状的稳定性和预后价值 对两个与ID相关且焦虑风险较高的人群进行诊断分类。同样，我们也是 有兴趣记录预测这两个人焦虑的出现、稳定性和严重性的因素 人口。

ABSTRACT Given the high prevalence and substantial impact of mental illness on individuals with intellectual disabilities (ID) studies that examine mental health in persons with ID are critical to direct treatment aimed at reduction and, more importantly, prevention of mental illness to improve functioning and quality of life. Fragile X syndrome (FXS) is the leading identified cause of ID with up to 80% of adolescents and adults with FXS meeting criteria for an anxiety disorder. FXS is an ideal model to investigate the combined and interactive effects among biological, behavioral and environmental factors on the emerging trajectory of anxiety in persons with ID. This application “Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome” proposes the first longitudinal prospective developmental study of the early features of anxiety in very young boys with FXS contrasted to boys diagnosed with ASD (non-FXS) and typical controls (TD). We are interested in the age at which initial features of anxiety can be detected and the stability and prognostic value of these early symptoms to diagnostic categorization across two populations associated with ID and at high risk for anxiety. Likewise, we are interested in documenting factors that predict the emergence, stability and severity of anxiety in these two populations.