Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome

摘要 鉴于精神疾病的高发病率和对智力残疾者的重大影响， (ID)检查ID患者心理健康的研究对于旨在减少 更重要的是，预防精神疾病，以改善功能和生活质量。脆性X FXS是ID的主要确定原因，高达80%的青少年和成人患有FXS 符合焦虑症的标准FXS是一种理想的研究组合和交互的模型 生物、行为和环境因素对人的焦虑出现轨迹的影响 本申请“脆性X综合征中焦虑的出现、稳定性和预测因素”提出了 FXS患儿早期焦虑特征的首次纵向前瞻性发展研究 与诊断为ASD（非FXS）和典型对照（TD）的男孩相比。我们感兴趣的是 焦虑的哪些初始特征可以被检测到，这些早期症状的稳定性和预后价值， 在两个与ID相关的人群和焦虑高危人群中进行诊断分类。同样，我们 感兴趣的是记录因素，预测出现，稳定性和严重性的焦虑，在这两个 人口。

ABSTRACT Given the high prevalence and substantial impact of mental illness on individuals with intellectual disabilities (ID) studies that examine mental health in persons with ID are critical to direct treatment aimed at reduction and, more importantly, prevention of mental illness to improve functioning and quality of life. Fragile X syndrome (FXS) is the leading identified cause of ID with up to 80% of adolescents and adults with FXS meeting criteria for an anxiety disorder. FXS is an ideal model to investigate the combined and interactive effects among biological, behavioral and environmental factors on the emerging trajectory of anxiety in persons with ID. This application “Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome” proposes the first longitudinal prospective developmental study of the early features of anxiety in very young boys with FXS contrasted to boys diagnosed with ASD (non-FXS) and typical controls (TD). We are interested in the age at which initial features of anxiety can be detected and the stability and prognostic value of these early symptoms to diagnostic categorization across two populations associated with ID and at high risk for anxiety. Likewise, we are interested in documenting factors that predict the emergence, stability and severity of anxiety in these two populations.