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Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome

脆性 X 综合征焦虑的出现、稳定性和预测因素

基本信息

批准号：
9764484
负责人：
Jane E Roberts
金额：
$ 62.67万
依托单位：
UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9764484
关键词：
3 year old 5 year old Address Adolescent Adult Age Anxiety Anxiety Disorders Attention deficit hyperactivity disorder Behavioral Biological Biological Markers Categories Child Child Rearing Clinical Cognition Comorbidity Complement Cross Syndrome Development Diagnosis Diagnostic Early Intervention Early identification Early treatment Environmental Risk Factor Etiology Eye FMR1 Fragile X Syndrome Genetic Heart Heritability Heterogeneity High Prevalence Hydrocortisone Impairment Individual Intellectual functioning disability Intervention Language Measurement Medical Medical Genetics Mental Health Mental disorders Methylation Modeling Mood Disorders Nursery Schools Outcome Personal Satisfaction Persons Physiological Population Predictive Factor Prevalence Prevalence Study Prevention Public Health Quality of life Recording of previous events Research Risk Severities Social Behavior Specificity Stress Subgroup Symptoms Time Work anxiety symptoms autism spectrum disorder autistic children behavior rating scale boys clinical heterogeneity comparison group critical developmental period functional outcomes high risk improved improved functioning interest male maternal anxiety meetings prognostic value prospective risk sharing

项目摘要

ABSTRACT Given the high prevalence and substantial impact of mental illness on individuals with intellectual disabilities (ID) studies that examine mental health in persons with ID are critical to direct treatment aimed at reduction and, more importantly, prevention of mental illness to improve functioning and quality of life. Fragile X syndrome (FXS) is the leading identified cause of ID with up to 80% of adolescents and adults with FXS meeting criteria for an anxiety disorder. FXS is an ideal model to investigate the combined and interactive effects among biological, behavioral and environmental factors on the emerging trajectory of anxiety in persons with ID. This application “Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome” proposes the first longitudinal prospective developmental study of the early features of anxiety in very young boys with FXS contrasted to boys diagnosed with ASD (non-FXS) and typical controls (TD). We are interested in the age at which initial features of anxiety can be detected and the stability and prognostic value of these early symptoms to diagnostic categorization across two populations associated with ID and at high risk for anxiety. Likewise, we are interested in documenting factors that predict the emergence, stability and severity of anxiety in these two populations.

摘要