Conduct of studies to compare the toxicity and toxicogenomic responses of five lots of Ginkgo Biloba Extract, Goldenseal Extract and Green Tea Extract in laboratory animals for NTP

进行研究，比较五批银杏叶提取物、白毛茛提取物和绿茶提取物对实验动物的 NTP 毒性和毒理基因组反应

• 批准号: 9471294
• 负责人: BARNEY SPARROW
• 金额: $ 2.05万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2018-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9471294
• 关键词: Animals; Biological; Chemicals; Epigallocatechin Gallate; Ginkgo biloba; Ginkgo biloba extract; Goals; Goldenseal; Green tea; Human; Laboratory Animals; Risk; Testing; Toxic effect; Toxicogenomics; hazard; response

The goal of this project is to compare the toxicity and toxicogenomic responses of five lots of ginkgo, including one used in the NTP 2-year studies, to determine if there are differences in response among the lots. Two other extracts (Goldenseal and Green Tea) are includes for comparison. These studies will provide information to inform various longer term toxicity studies on Ginkgo Biloba extract and aid in determining if the different extracts cause different biological responses. These studies have recently ended. Keywords: toxicity, toxicognenomics, Ginkgo Biloba, Goldenseal, Green tea.

本项目的目标是比较五批银杏的毒性和毒理基因组学反应，包括NTP 2年研究中使用的一批，以确定批次之间的反应是否存在差异。另外两种提取物（毛茛和绿色茶）也包括在内以供比较。这些研究将为银杏叶提取物的各种长期毒性研究提供信息，并有助于确定不同的提取物是否会引起不同的生物反应。这些研究最近已经结束。 关键词：毒性，毒理基因组学，银杏，白毛茛，绿色茶。