LIFECODES pregnancy cohort

LIFECODES 妊娠队列

• 批准号: 9550228
• 负责人: Kelly Ferguson
• 金额: $ 16.85万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9550228
• 关键词: Address; Adverse effects; Aromatic Polycyclic Hydrocarbons; Biological; Biological Markers; Birth; Boston; Case-Control Studies; Chemical Exposure; Data; Data Collection; Endocrine disruption; Environmental Exposure; Environmental Pollution; Environmental Risk Factor; Exposure to; Fetal Development; Fetal Growth; Fetal Growth Retardation; Goals; Hospitals; Inflammation; Maternal Exposure; Measures; Mediating; Metal exposure; Metals; Oxidative Stress; Participant; Phenols; Phenotype; Pilot Projects; Placentation; Population; Pre-Eclampsia; Predisposition; Pregnancy; Premature Birth; Prevention; Recruitment Activity; Research; Research Project Grants; Techniques; Time; Trace metal; Ultrasonography; Visit; Woman; Work; adverse pregnancy outcome; bisphenol A; cohort; environmental chemical exposure; insight; metabolomics; phthalates; prospective; sample collection; study population; urinary

Over the course of this year Dr. Ferguson expanded her previous work in this study population to examine oxidative stress and inflammation as potential mechanisms mediating associations between environmental chemical exposures and adverse pregnancy outcomes. Specifically, she examined oxidative stress and inflammation biomarkers measured at multiple time points in pregnancy in relation to preeclampsia and fetal growth. She also examined some new chemical exposure biomarkers (polycyclic aromatic hydrocarbons and phenolic compounds) in relation to these intermediate biomarkers and in relation to adverse pregnancy outcomes. Additionally, she performed a pilot study to collect urinary metals data on 482 women from a case-control study of preterm birth nested within LIFECODES in tandem with metabolomics profiles. Data is pending for the latter project. Finally, she visited with Dr. McElrath in Boston and developed plans for two pilot projects for 1) examining phenotypes of fetal growth restriction, and 2) expanding the existing sample and data collection in LIFECODES to more completely capture environmental exposures and to gain additional insight on placental and fetal development.

在这一年中，Ferguson博士扩展了她之前在该研究人群中的工作，以检查氧化应激和炎症作为介导环境化学物质暴露与不良妊娠结局之间关联的潜在机制。具体来说，她检查了妊娠期间多个时间点测量的氧化应激和炎症生物标志物与子痫前期和胎儿生长的关系。她还研究了一些新的化学暴露生物标志物（多环芳烃和酚类化合物）与这些中间生物标志物和不良妊娠结局的关系。此外，她还进行了一项试点研究，收集了482名妇女的尿液金属数据，这些数据来自一项早产儿病例对照研究，该研究与代谢组学资料相结合。后一个项目的数据尚未公布。最后，她拜访了波士顿的McElrath博士，并制定了两个试点项目的计划：1)检查胎儿生长限制的表型，2)扩展LIFECODES中现有的样本和数据收集，以更全面地捕捉环境暴露，并获得更多关于胎盘和胎儿发育的见解。