Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stress

邻苯二甲酸盐和压力生活事件暴露与妊娠结局：氧化应激的作用

• 批准号: 9550214
• 负责人: Kelly Ferguson
• 金额: $ 8.43万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9550214
• 关键词: Attention; Biological; Biological Markers; Birth; Birthing Centers; Chemicals; Child Development; Cost of Illness; Data; Data Analyses; Data Collection; Development; Diet; Dietary Supplementation; Disease; Elderly; Environment; Environmental Exposure; Environmental Health; Event; Exposure to; First Pregnancy Trimester; Free Radicals; Goals; Growth; Immunity; Individual; Infant; Infant Development; Inflammation; Investigation; Laboratories; Life; Measurement; Mediator of activation protein; Medical Records; Metabolism; Modification; Mothers; National Institute of Environmental Health Sciences; Omega-3 Fatty Acids; Outcome; Oxidative Stress; Participant; Pathogenesis; Pathway interactions; Plant Roots; Positioning Attribute; Pregnancy; Pregnancy Outcome; Publications; Publishing; Questionnaires; Research; Research Personnel; Role; Sampling; Site; Source; Supplementation; Testing; Third Pregnancy Trimester; Time; Urine; adverse pregnancy outcome; cohort; early childhood; economic cost; experience; fetal; improved; insight; interest; maternal stress; medical schools; novel; phthalates; remediation; reproductive tract; stressor; urinary

This project aligns well with the strategic goals of NIEHS by: 1) Including investigation of how combined environmental exposures impact disease pathogenesis; 2) Improving understanding of a shared biological pathway, in this case oxidative stress, underlying the impact of these exposures; and 3) Investigating how exposures during pregnancya critical window of susceptibilityrelate to the early life development of the child. This project was initiated this year, and thus does not have any publications to date. However, since beginning my position at NIEHS in January, I have made several substantial steps toward data collection. First, with input from investigators in the Free Radical Metabolism Group (Immunity, Inflammation, and Disease Branch), I have established the laboratory that will be utilized for oxidative stress analyses in urine samples and have a sole source justification pending. Second, I optimized a medical record abstraction form with collaborator Dr. Thomas McElrath to obtain additional information from TIDES participants on specific delivery outcomes. Third, I have received IRB approval for a modification to abstract this data from the Icahn School of Medicine at Mount Sinai. I am now working with the TIDES study team at the four individual study sites to obtain approval for the modifications there as well. Lastly, I have obtained an exemption from NIEHS so that I may utilize the data collected from the study. During the next year I anticipate receiving data on urinary oxidative stress biomarkers, medical record data, and urinary phthalate metabolites from the third trimester of pregnancy, and will begin analyzing data and publishing the results from this study.

该项目通过以下方式与 NIEHS 的战略目标高度契合： 1) 包括调查综合环境暴露如何影响疾病发病机制； 2) 提高对共同生物途径的理解，在本例中氧化应激是这些暴露影响的基础； 3) 研究怀孕期间的暴露（易感性的关键窗口）如何与儿童的早期生命发育相关。该项目于今年启动，因此迄今为止没有任何出版物。然而，自从一月份开始在 NIEHS 任职以来，我在数据收集方面迈出了几个实质性的步骤。首先，根据自由基代谢小组（免疫、炎症和疾病部门）研究人员的意见，我建立了一个实验室，将用于尿液样本中的氧化应激分析，并且有唯一的来源理由待定。其次，我与合作者 Thomas McElrath 博士优化了医疗记录摘要表格，以从 TIDES 参与者那里获取有关具体分娩结果的更多信息。第三，我已获得 IRB 批准进行修改，以从西奈山伊坎医学院提取此数据。我现在正在与 TIDES 研究团队在四个单独的研究地点合作，以获得对那里的修改的批准。最后，我获得了 NIEHS 的豁免，以便我可以利用从研究中收集的数据。在明年，我预计会收到有关妊娠晚期尿液氧化应激生物标志物、医疗记录数据和尿液邻苯二甲酸盐代谢物的数据，并将开始分析数据并发布这项研究的结果。