Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stress

本项目符合NIEHS的战略目标，包括：1)研究综合环境暴露对疾病发病机制的影响；2)提高对共同生物途径的理解，在这种情况下，氧化应激是这些暴露影响的基础；3)调查怀孕期间的暴露（易感的关键窗口）与儿童早期生活发展的关系。这个项目是今年开始的，因此到目前为止还没有任何出版物。然而，自从我1月份开始在NIEHS任职以来，我已经在数据收集方面迈出了一些实质性的步骤。首先，根据自由基代谢组（免疫、炎症和疾病分支）研究人员的意见，我建立了一个实验室，将用于尿液样本的氧化应激分析，并有一个唯一的来源证明。其次，我与合作者Thomas McElrath医生一起优化了医疗记录抽象表，以从TIDES参与者那里获得关于特定分娩结果的额外信息。第三，我已经收到了IRB批准的修改，从西奈山的伊坎医学院提取数据。我现在正与TIDES研究小组在四个单独的研究地点合作，以获得对那里的修改的批准。最后，我已经获得了NIEHS的豁免，以便我可以使用从研究中收集的数据。在接下来的一年里，我预计会收到关于尿氧化应激生物标志物、医疗记录数据和妊娠晚期尿邻苯二甲酸盐代谢物的数据，并将开始分析数据并发表这项研究的结果。

This project aligns well with the strategic goals of NIEHS by: 1) Including investigation of how combined environmental exposures impact disease pathogenesis; 2) Improving understanding of a shared biological pathway, in this case oxidative stress, underlying the impact of these exposures; and 3) Investigating how exposures during pregnancya critical window of susceptibilityrelate to the early life development of the child. This project was initiated this year, and thus does not have any publications to date. However, since beginning my position at NIEHS in January, I have made several substantial steps toward data collection. First, with input from investigators in the Free Radical Metabolism Group (Immunity, Inflammation, and Disease Branch), I have established the laboratory that will be utilized for oxidative stress analyses in urine samples and have a sole source justification pending. Second, I optimized a medical record abstraction form with collaborator Dr. Thomas McElrath to obtain additional information from TIDES participants on specific delivery outcomes. Third, I have received IRB approval for a modification to abstract this data from the Icahn School of Medicine at Mount Sinai. I am now working with the TIDES study team at the four individual study sites to obtain approval for the modifications there as well. Lastly, I have obtained an exemption from NIEHS so that I may utilize the data collected from the study. During the next year I anticipate receiving data on urinary oxidative stress biomarkers, medical record data, and urinary phthalate metabolites from the third trimester of pregnancy, and will begin analyzing data and publishing the results from this study.