LIFECODES pregnancy cohort

LIFECODES 妊娠队列

• 批准号: 9785218
• 负责人: Kelly Ferguson
• 金额: $ 47.04万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9785218
• 关键词: Address; Adverse effects; Biological; Biological Markers; Birth; Boston; Case-Control Studies; Child Health; Data; Data Analyses; Endocrine disruption; Environmental Pollution; Environmental Risk Factor; Exposure to; Fetal Diseases; Fetal Growth; Fetal Growth Retardation; Goals; Growth; Hospitals; Individual; Inflammation; Institutes; Manuscripts; Maternal Exposure; Measures; Metal exposure; Molecular; Oxidative Stress; Physiology; Pilot Projects; Pre-Eclampsia; Predisposition; Pregnancy; Premature Birth; Preparation; Prevention; Publications; Research; Research Design; Research Project Grants; Resources; Techniques; Trace metal; Ultrasonography; Visit; Woman; Work; adverse pregnancy outcome; bisphenol A; cohort; metabolomics; phthalates; prenatal environmental exposure; prospective; recruit; urinary

Over the course of this year, Dr. Ferguson met several goals. First, she collected data on urinary trace metals and non-targeted metabolomic profiles within the case-control study of preterm birth. This was a pilot project under the Childrens Health Exposure Assessment Resource. Several manuscripts from this project are in preparation, summarizing findings on the relationships between urinary trace metals individually as well as in mixtures in relation to preterm birth as well as preeclampsia. Second, Dr. Ferguson worked with collaborators at the Duke Molecular Physiology Institute to examine the relationship between non-targeted urinary metabolomic profiles in relation to growth restriction in a pilot case-control study. Findings from this study are currently in preparation for publication. Finally, she initiated a pilot project for the creation of a new case-control study designed to investigate the relationship between prenatal environmental exposures and disorders of fetal growth in pregnancy.

在这一年里，弗格森博士实现了几个目标。首先，她在早产病例对照研究中收集了尿微量金属和非靶向代谢组学特征的数据。这是儿童健康暴露评估资源下的一个试点项目。该项目的几份手稿正在准备中，总结了尿微量金属单独以及混合物与早产和先兆子痫之间关系的研究结果。其次，Ferguson博士与杜克分子生理学研究所的合作者合作，在一项试点病例对照研究中研究了非靶向尿代谢组学特征与生长受限之间的关系。这项研究的结果目前正在准备出版。最后，她发起了一个试点项目，创建一个新的病例对照研究，旨在调查产前环境暴露和胎儿在怀孕期间生长障碍之间的关系。