LIFECODES pregnancy cohort
LIFECODES 妊娠队列
基本信息
- 批准号:10924978
- 负责人:
- 金额:$ 105.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:37 weeks gestationAddressBiological MarkersBirthBloodBostonChemical ExposureChemicalsChildhoodCollaborationsDataData PoolingEnvironmental ExposureEnvironmental PollutantsEtiologyFetal DiseasesFetal GrowthFetal Growth RetardationFlame RetardantsGestational AgeGrowthGrowth DisordersHealthHistologyHospitalsIndividualInflammationInflammatoryInvestigationMeasuresMediatingMediatorMetabolicMetal exposureMetalsMethodsNational Institute of Environmental Health SciencesNewborn InfantOrganophosphatesOutcomeOxidative StressOxidative Stress PathwayPaperParticipantPesticidesPhenolsPhenotypePilot ProjectsPregnancyPregnancy TrimestersPremature BirthPreventionProductionPublishingReactive Oxygen SpeciesResearchResearch PersonnelResearch Project GrantsResourcesSmall for Gestational Age InfantSpecimenStatistical MethodsThird Pregnancy TrimesterTimeTrace metalUrineadverse birth outcomesadverse pregnancy outcomeage groupcase controlcohortconsumer productenvironmental chemical exposurefatty acid oxidationgestational weight gainimprovedinnovationinsightlipidomicsmetabolomicsphthalatesprenatal exposureprepregnancyprogramsprospectiveultrasoundurinary
项目摘要
LIFECODES is an ongoing prospective birth cohort conducted at Brigham and Womens Hospital in Boston, MA by Dr. Thomas McElrath. Begun in 2006, this study aims to investigate environmental contaminants associated with adverse pregnancy outcomes, isolate mechanisms underlying their associations, and identify predictors that can be used for prevention. Within this cohort there are several research projects which exist to address more specific research questions. At NIEHS we have utilized this existing data and added to it in three ways. First, we collaborate with investigators on a case-control sub-study of preterm birth. Within that sub-study, as a pilot study in the Childrens Health Exposure Assessment Resource (CHEAR) program, we analyzed urinary trace metals as well as metabolomics in urine specimens from the 3rd trimester of pregnancy. The objectives of this project were to examine each individual trace metals as well as metal mixtures in relation to: 1) overall preterm birth (delivery <37 weeks gestation) as well as preterm birth subtypes (spontaneous and placentally mediated); 2) fetal growth as assessed by ultrasound measures in pregnancy; and 3) urinary oxidative stress biomarkers that were also measured at that time point. Additionally, we sought to examine metabolomics profiles as potential mediators of these associations. The second project based under the LIFECODES pregnancy cohort is a pooled study. Based on our initial findings, we pooled data from LIFECODES and 15 other US pregnancy or pre-pregnancy cohorts to more robustly investigate the relationship between phthalate exposure in pregnancy and preterm birth. The last project under the LIFECODES pregnancy cohort is an investigation of the associations between consumer product chemical exposure in pregnancy and their cumulative impact on disorders of fetal growth. Following a pilot study, we selected a random subcohort of 500 participants from among the overall LIFECODES cohort, and we enriched the cohort with additional selection of 200 cases of small-for-gestational age (SGA) births and 200 large-for-gestational age (LGA) births. Under this project, the LIFECODES Fetal Growth Study, our specific aims are to: 1) Examine associations between consumer product chemicals, including phthalates, phenols, and organophosphate flame retardants and pesticides, in relation to disorders of growth in pregnancy; 2) Improve the understanding of the etiologies of SGA and LGA, specifically targeting inflammatory and oxidative stress pathways; and 3) Within pregnancies resulting in an SGA newborn, explore phenotypes of growth restrictions using serial ultrasound measures of fetal growth.
In the past year, we published the first papers from the LIFECODES Fetal Growth Study, examining trajectories of fetal growth among babies born small and large for gestational age at delivery (PMIDs: 36027952, 36241081). We also began to publish descriptive papers on the environmental exposures measured in our cohort, including phthalates and phenols (PMID: 37001215). Additionally, on topics related to our aims in the LIFECODES study, we published a statistical methods paper (PMID: 35909228), a review paper (PMID: 35367517), an investigation of prenatal exposure and gestational weight gain (PMID: 36841368), and contributed to a consortium effort to examine urinary oxidative stress biomarkers in association with preterm birth (PMID: 36400174).
LIFECODES是一项由托马斯麦克尔拉特博士在马萨诸塞州波士顿布里格姆妇女医院进行的持续前瞻性出生队列研究。该研究始于2006年,旨在调查与不良妊娠结局相关的环境污染物,分离其相关机制,并确定可用于预防的预测因子。在这一群体中,有几个研究项目是为了解决更具体的研究问题。在NIEHS,我们已经利用了现有的数据,并以三种方式添加到它。首先,我们与研究人员合作进行早产的病例对照子研究。在该子研究中,作为儿童健康暴露评估资源(CHEARS)计划的试点研究,我们分析了妊娠晚期尿液标本中的尿微量金属和代谢组学。本项目的目的是检查每种微量金属以及金属混合物与以下方面的关系:1)总体早产(分娩<37周妊娠)以及早产亚型(自发性和胎盘介导的); 2)妊娠期超声测量评估的胎儿生长; 3)在该时间点测量的尿液氧化应激生物标志物。此外,我们试图检查代谢组学概况作为这些协会的潜在介质。LIFECODES妊娠队列的第二个项目是一项汇总研究。基于我们的初步发现,我们汇总了来自LIFECODES和其他15个美国妊娠或孕前队列的数据,以更有力地研究妊娠期邻苯二甲酸酯暴露与早产之间的关系。LIFECODES妊娠队列的最后一个项目是调查妊娠期消费品化学品暴露与其对胎儿生长障碍的累积影响之间的关联。在一项初步研究之后,我们从整个LIFECODES队列中随机选择了500名参与者,并通过额外选择200例小于胎龄(SGA)出生和200例大于胎龄(LGA)出生来丰富队列。在这个项目下,LIFECODES胎儿生长研究,我们的具体目标是:1)检查消费品化学品之间的关联,包括邻苯二甲酸酯,酚类,有机磷阻燃剂和农药,在怀孕期间的生长障碍; 2)提高对SGA和LGA的病因学的理解,特别是针对炎症和氧化应激途径;和3)在导致SGA新生儿的妊娠中,使用胎儿生长的系列超声测量来探索生长限制的表型。
在过去的一年里,我们发表了LIFECODES胎儿生长研究的第一篇论文,研究了出生时胎龄较小和较大的婴儿的胎儿生长轨迹(PMID:36027952,36241081)。我们还开始发表关于在我们的队列中测量的环境暴露的描述性论文,包括邻苯二甲酸酯和苯酚(PMID:37001215)。此外,关于与我们在LIFECODES研究中的目标相关的主题,我们发表了一篇统计方法论文(PMID:35909228),一篇综述论文(PMID:35367517),产前暴露和妊娠期体重增加的研究(PMID:36841368),并参与了一个研究与早产相关的尿氧化应激生物标志物的联盟(PMID:36400174)。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Inflammation and oxidative stress as mediators of the impacts of environmental exposures on human pregnancy: Evidence from oxylipins.
- DOI:10.1016/j.pharmthera.2022.108181
- 发表时间:2022-11
- 期刊:
- 影响因子:13.5
- 作者:Welch BM;McNell EE;Edin ML;Ferguson KK
- 通讯作者:Ferguson KK
An application of group-based trajectory modeling to define fetal growth phenotypes among small-for-gestational-age births in the LIFECODES Fetal Growth Study.
应用基于群体的轨迹模型来定义 LIFECODES 胎儿生长研究中小于胎龄儿的胎儿生长表型。
- DOI:10.1016/j.ajog.2022.08.041
- 发表时间:2023
- 期刊:
- 影响因子:9.8
- 作者:Bommarito,PaigeA;Cantonwine,DavidE;Stevens,DanielleR;Welch,BarrettM;Davalos,AngelD;Zhao,Shanshan;McElrath,ThomasF;Ferguson,KellyK
- 通讯作者:Ferguson,KellyK
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Kelly Ferguson其他文献
Kelly Ferguson的其他文献
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{{ truncateString('Kelly Ferguson', 18)}}的其他基金
Environmental phthalate exposure in the Human Placenta Project cohort
人类胎盘项目队列中的环境邻苯二甲酸盐暴露
- 批准号:
10924986 - 财政年份:
- 资助金额:
$ 105.57万 - 项目类别:
The Generation R cohort study as an NIEHS resource
作为 NIEHS 资源的 R 世代队列研究
- 批准号:
10924956 - 财政年份:
- 资助金额:
$ 105.57万 - 项目类别:
Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stress
邻苯二甲酸盐和压力生活事件暴露与妊娠结局:氧化应激的作用
- 批准号:
9550214 - 财政年份:
- 资助金额:
$ 105.57万 - 项目类别:
The Generation R cohort study as an NIEHS resource
作为 NIEHS 资源的 R 世代队列研究
- 批准号:
10008726 - 财政年份:
- 资助金额:
$ 105.57万 - 项目类别:
Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stress
邻苯二甲酸盐和压力生活事件暴露与妊娠结局:氧化应激的作用
- 批准号:
10008732 - 财政年份:
- 资助金额:
$ 105.57万 - 项目类别:
The Generation R cohort study as an NIEHS resource
作为 NIEHS 资源的 R 世代队列研究
- 批准号:
10249858 - 财政年份:
- 资助金额:
$ 105.57万 - 项目类别:
Oxidative stress as a mediator of environmental exposure impacts on fertility endpoints
氧化应激作为环境暴露影响生育终点的中介因素
- 批准号:
10248902 - 财政年份:
- 资助金额:
$ 105.57万 - 项目类别:
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