Oxidative stress as a mediator of environmental exposure impacts on fertility endpoints

该项目扩展了弗格森博士对氧化应激的研究，将其作为连接环境污染物暴露与不良生殖和怀孕后果的统一机制。该项目的概念于2016年8月提交给流行病学分部，并获得批准。此外，我们还在选择实验室分析氧化应激措施方面取得了进展，并确定了我们将在本研究中使用的样本采集的对象和特定时间点。在下一个历年，我们预计完成尿氧化应激生物标记物的分析，并发表这项研究的主要发现。

This project extends Dr. Fergusons research into oxidative stress as a unifying mechanism connecting environmental contaminant exposure to adverse reproductive and pregnancy outcomes. The concept for this project was presented to the Epidemiology Branch in August of 2016 and received approval. We have additionally made progress toward selecting a laboratory for analysis of oxidative stress measures, and toward identifying subjects and specific time points of sample collection that we will utilize in the present study. Over the next calendar year we anticipate completion of urinary oxidative stress biomarker analysis and publishing the primary findings from this study.