Overall Center Research Strategy

俄亥俄州立大学监管卓越中心的总体愿景 烟草科学(OSU-CERTS)将作为国家领导者提供相关的科学数据来支持 FDA在烟草产品中心的监管决策。OSU-CERTS的总体主题是 了解烟草产品偏好的原因，特别是双重用途和多种用途，以及如何 这些原因影响了在不断变化的不同类型烟草产品环境中的使用。这个 该中心将把这一主题纳入在自然环境中进行的一系列青少年和成人队列研究中， 辅以控制良好的实验研究，允许进行因果推断。要完成以下任务 上面，我们将利用人口危害模型(图1)，其中对人口的伤害是 个人疾病风险和接触者的人数。OSUCERT的主要研究领域 这将有助于FDA包括广告和营销的影响；认知和情感 对决策的影响；关注无烟烟草(ST)和双重用途；城市和农村的使用 提高普及性的人群；以及涵盖烟草使用者范围的协同研究 从青少年到成年人。我们的中心将解决FDA在1月份提出的56项研究优先事项中的11项， 2012年。

The overall vision of The Ohio State University Center of Excellence in Regulatory Tobacco Science (OSU-CERTS) is to serve as a national leader in providing relevant scientific data to support FDA regulatory decision making in the Center for Tobacco Products. The overall theme of OSU-CERTS is to understand the reasons for underiying tobacco-product preferences, especially dual and poly-use, and how these reasons influence use in an environment of ever-changing diverse types of tobacco products. The Center will integrate this theme in a series of adolescent and adult cohort studies conducted in natural settings, complemented by well-controlled experimental studies that allow for causal inference. To accomplish the above, we will utilize a population harm model (Figure 1), where harm to the population is the result of individual disease risk and the number of persons who are exposed. The major research areas of the OSUCERTs that will assist the FDA include the impact of advertising and marketing; cognitive and affective influences in decision making; a focus on smokeless tobacco (ST) and dual use; use of both urban and rural populations to enhance generalizability; and synergistic studies that cover the range of tobacco users from adolescents to adults. Our Center will address 11 of 56 research priorities set forth by the FDA in January, 2012.