Early Adversity, Childhood Educational Experiences, and Adulthood Physical Health

早期逆境、童年教育经历和成年身体健康

• 批准号: 9284294
• 负责人: Maria E. Bleil
• 金额: $ 53.3万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-12 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9284294
• 关键词: Academic achievement; Academic skills; Achievement; Address; Adolescent; Adult; Affect; Age; Behavioral; Birth; Blood; Cardiovascular Diseases; Child; Child Care; Childhood; Data Collection; Data Set; Development; Education; Educational Status; Environment; Ethnic Origin; Evaluation; Event; Family; Fathers; Female; Funding; Gender; Health; Health behavior; Home environment; Infant; Inflammation; Instruction; Intelligence; Intervention; Life; Life Cycle Stages; Life Style; Link; Literature; Measures; Mediating; Mediator of activation protein; Medical History; Metabolic; Modeling; Mothers; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; Nature; Onset of illness; Outcome; Participant; Pathway interactions; Physical Examination; Physical activity; Positioning Attribute; Prevention; Prospective Studies; Questionnaires; Race; Reporting; Research Support; Risk; Risk Marker; Sampling; Sampling Studies; Schools; Sum; Temperament; Testing; Time; United States National Institutes of Health; Variant; Visit; base; cardiovascular health; cohort; design; disorder risk; early childhood; experience; follow-up; infancy; lifestyle factors; male; maltreatment; mortality; physical conditioning; prospective; sex; teacher

PROJECT SUMMARY: Although the association between educational attainment and physical health outcomes—including leading causes of mortality like cardiovascular disease—is well known to be large in magnitude, enduring over the life course, and invariant across sex, race, and ethnicity, there are few existing studies that are capable of prospectively disambiguating aspects of early education that are most predictive of physical health in adulthood and thus most productively targeted in intervention and prevention efforts. Likewise, few studies of the school context are also well positioned to incorporate in the same sample correlated aspects of risk in children's early home environments that might initiate a developmental cascade resulting in poorer physical health outcomes in adulthood via childhood educational experiences. To address these limitations, the current application is designed to leverage the landmark NICHD Study of Early Child Care and Youth Development (SECCYD; 1991- 2006), a large-scale, prospective study of children thus far followed prospectively from birth, to evaluate a life course model whereby early life adversity is hypothesized to confer risk for intermediate health outcomes relevant to health risk partially through correlated variation in both a) academic achievement and attainment and b) educational experiences during childhood (e.g., the quality of educational experiences, both interpersonal and instructional in nature). Building on an NHLBI-sponsored follow-up of the female sub-sample of the SECCYD (pending R01HL130103, PI: Bleil, to begin 7/1/16), funding for the current application will enable identical assessments in the male participants including relevant parameters of health/disease risk. This effort will produce a high powered study of 750 total SECCYD participants (~50% male; ages 25-30 over study period), assuming 80% return of 940 participants. The follow-up visit will involve assessments in domains of cardio-metabolic and inflammation known to predict long-term risk for disease derived from a physical examination, blood draw, and comprehensive medical history/health behavior evaluation. These new measures generated from the current study will be examined in relation to existing, state-of-the-art assessments of early life environments and educational achievement/experiences acquired as a part of the original SECCYD data collection on both genders. Early life adversity will be characterized using measures of childhood SES, infant-mother attachment, maternal sensitivity, father absence, negative life events, and maltreatment. Academic achievement will be assessed using teacher-reported and objective assessments of academic skills whereas educational experiences will be studied using classroom observations along with questionnaire assessments of the quality of teacher-child relationships. In sum, the proposed study reflects a unique, time-sensitive opportunity to examine longitudinally the extent to which academic achievement and/or the quality of childhood educational experiences uniquely predict health risk in adulthood, as well as to explore childhood variables that moderate, and adult behavioral/lifestyle variables that mediate these prospective associations.

项目概要： 尽管教育程度与身体健康结果（包括领导力）之间存在关联 心血管疾病等死亡原因众所周知，其影响范围很大，并且会持续一生 当然，并且在性别、种族和民族之间不变，现有的研究很少能够 前瞻性地消除早期教育中最能预测成年后身体健康的方面 从而最有成效地开展干预和预防工作。同样，学校的研究也很少 背景也能够很好地将儿童早期风险的相关方面纳入同一样本中。 家庭环境可能会引发连锁反应，导致身体健康状况较差 通过童年的教育经历成年。为了解决这些限制，当前的应用程序是 旨在利用具有里程碑意义的 NICHD 早期儿童保育和青少年发展研究（SECCYD；1991- 2006），这是迄今为止对儿童进行的一项大规模前瞻性研究，从出生起就对其进行前瞻性跟踪，以评估其一生 假设生命早期的逆境会给中期健康结果带来风险的课程模型 与健康风险相关的部分是通过以下方面的相关变化：a) 学术成就和成就； b) 童年时期的教育经历（例如，人际交往和教育经历的质量） 教学性质）。以 NHLBI 赞助的 SECCYD 女性子样本后续行动为基础 （待定 R01HL130103，PI：Bleil，将于 2016 年 7 月 1 日开始），当前申请的资金将实现相同的 对男性参与者的评估，包括健康/疾病风险的相关参数。这项努力将产生 一项针对 750 名 SECCYD 参与者（约 50% 男性；研究期间年龄为 25-30 岁）的高水平研究，假设 940 名参与者的回报率为 80%。后续访问将涉及心脏代谢和 已知可预测长期疾病风险的炎症来自体检、抽血和 综合病史/健康行为评估。这些新措施是在现行政策的基础上产生的 将结合现有的、最先进的早期生活环境评估来审查研究 作为原始 SECCYD 数据收集的一部分获得的教育成就/经验 性别。早期生活逆境将通过儿童社会经济地位、母婴依恋、 母亲敏感、父亲缺席、负面生活事件和虐待。学术成就将是 使用教师报告的学术技能客观评估进行评估，而教育 将使用课堂观察以及质量问卷评估来研究经验 的师生关系。总之，拟议的研究反映了一个独特的、时间敏感的机会来检验 纵向而言，学业成绩和/或儿童教育经历的质量 独特地预测成年期的健康风险，并探索调节和成年期健康风险的童年变量 调节这些预期关联的行为/生活方式变量。