Kinases: Next-Generation Insights and Approaches

摘要 请求支持题为Kinase：下一代洞察力和 由Reid M.Huber博士、John Kuriyan博士和Ruth H.Palmer博士组织。会议将在#年举行。 2017年3月5日至9日，科罗拉多州布雷肯里奇。几十年来，基础和应用研究都取得了进展 明确地确立了磷酸转移酶的激酶家族在几乎每一个 生物动态平衡的一个方面。这些进展已经产生了变革性的治疗方法 疾病，最显著的是在癌症领域，在那里抑制激酶有助于实现精确度的承诺 医药。然而，即使在今天，我们对这类酶的复杂性的看法仍在继续演变， 该领域许多最令人兴奋的进展都是通过应用现代洞察力和 这些酶在健康和人类疾病中扮演不同角色的技术方法。这 会议将致力于探索这一基础和应用激酶研究的创新前沿，并将 汇聚学术、临床和制药领域的顶尖研究人员，探索和定义 激酶生物学领域的新视野，重点是癌症研究和翻译 发展。

ABSTRACT Support is requested for a Keystone Symposia meeting entitled Kinases: Next-Generation Insights and Approaches, organized by Drs. Reid M. Huber, John Kuriyan and Ruth H. Palmer. The meeting will be held in Breckenridge, Colorado from March 5-9, 2017. Decades of advances in both basic and applied research have unequivocally established the importance the kinase family of phosphotransferase enzymes in virtually every aspect of organismal homeostasis. These advances have yielded transformative therapeutic approaches to disease, most notably in the field of cancer where kinase inhibition is helping to fulfill the promise of precision medicine. Yet even today, our perspectives on the complexity of this class of enzymes continues to evolve, and many of the most exciting advancements in the field are being made by applying modern-day insights and technological approaches to the diverse roles the enzymes can play in health and human disease. This meeting will be devoted to exploring this innovative leading edge of basic and applied kinase research, and will bring together leading researchers from academic, clinical and pharmaceutical settings to explore and define the new horizons in the field of kinase biology, with a focus on cancer research and translational development.