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Cell Plasticity within the Tumor Microenvironment

肿瘤微环境中的细胞可塑性

基本信息

批准号：
9194760
负责人：
Jane Peterson
金额：
$ 0.45万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-01-01 至 2017-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9194760
关键词：
Address Area Awareness Basic Science Cancer Biology Cells Cellular biology Cessation of life Chronic Collaborations Complex Conflict (Psychology)Data Analyses Decision Modeling Development Discipline Distant Educational workshop Environment Environmental Risk Factor Event Functional disorder Future Generations Genetic Health Human Image Immune Immunology Injury Knowledge Malignant Neoplasms Mediating Mediator of activation protein Mentors Methodology Molecular Montana Neoplasm Metastasis Outcome Pathway interactions Pharmacologic Substance Phenotype Process Research Research Personnel Role Science Scientist Shapes Signal Pathway Signal Transduction Stem cells Stromal Cells Stromal Neoplasm Therapeutic Translational Research Treatment Efficacy Tumor Stem Cells Tumorigenicity Update cancer cell cell type clinical practice design meetings mutant neoplastic cell novel novel therapeutics polarized cell posters prospective stem cell biology symposium therapy resistant tumor tumor heterogeneity tumor microenvironment tumorigenic

项目摘要

ABSTRACT Support is requested for a Keystone Symposia meeting entitled Cell Plasticity within the Tumor Microenvironment, organized by Drs. Sergei Grivennikov, Florian R. Greten and Mikala Egeblad. The meeting will be held in Big Sky, Montana from January 8-12, 2017. During the last decade, it has become unequivocally evident that tumor development is not a cell-autonomous process but rather depends on the intricate reciprocal interplay of mutant tumor cells with their local and distant environments. Composition and polarization of cells in the tumor microenvironment depends on genetic as well as environmental factors and is directly influenced by tumor therapy. Indeed, therapies that aim to shape the local immune milieu and consecutive signaling pathways in both stromal and tumor/stem cells address the complex pathophysiology of tumors more adequately and may therefore add substantial benefits for therapy. An absolute pre-requisite for such an endeavor is a comprehensive understanding of the exact molecular basis of the complex signaling networks in the tumor microenvironment that control the plasticity of both stromal and tumor cells, thereby shaping the complex cellular contexture, which ultimately forms a pro- or anti-tumorigenic milieu. Thus, this symposium aims to gather a comprehensive functional understanding of mediator-dependent cellular and molecular events that are responsible for the plasticity of both stromal and tumor/stem cells. It will bring together experts in cancer, stromal and immune cells to synthesize scientific knowledge about the phenomenon of cell plasticity within the tumor microenvironment, to define molecular and cellular pathways mediating plasticity and to propose approaches to interfere with cell plasticity for a new generation of effective therapeutic approaches in cancer and chronic injury. Importantly, the meeting will bring together interdisciplinary groups of scientists or investigators who normally would not have an opportunity to meet (classical cancer biologists, tumor immunobiologists, stem cell experts and scientists working on stromal cells).

摘要要求支持一个名为肿瘤内细胞可塑性的Keystone研讨会会议微环境，由Sergei Grivennikov，Florian R. Greten和Mikala Egeblad会议将于2017年1月8日至12日在蒙大拿州的Big Sky举行。在过去的十年里，它已经成为明确地表明，肿瘤的发展不是一个细胞自主的过程，而是取决于细胞的生长。突变肿瘤细胞与其本地和远程环境的复杂相互作用。组成和肿瘤微环境中细胞的极化取决于遗传和环境因素，直接受到肿瘤治疗的影响。事实上，旨在塑造局部免疫环境并基质细胞和肿瘤/干细胞中的连续信号传导途径解决了肿瘤的复杂病理生理学，肿瘤更充分，因此可以增加治疗的实质性益处。绝对的先决条件，这种奋进是对复杂信号传导的确切分子基础的全面理解肿瘤微环境中控制基质细胞和肿瘤细胞可塑性的网络，形成复杂的细胞结构，最终形成促肿瘤发生或抗肿瘤发生的环境。因此，这研讨会的目的是收集一个全面的功能理解介导依赖细胞，负责基质细胞和肿瘤/干细胞可塑性的分子事件。它将带来在癌症，基质和免疫细胞的专家一起，综合科学知识，肿瘤微环境中的细胞可塑性现象，以确定分子和细胞途径介导可塑性，并提出干扰细胞可塑性的新一代有效方法，癌症和慢性损伤的治疗方法。重要的是，会议将汇集科学家或研究人员的跨学科小组，他们通常没有机会见面，（经典癌症生物学家、肿瘤免疫生物学家、干细胞专家和从事基质细胞研究的科学家）。