DNA Replication and Recombination

DNA复制和重组

• 批准号: 9329755
• 负责人: Jane Peterson
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-27 至 2018-03-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9329755
• 关键词: Address; Area; Biochemical; Cells; Chromatin; Collaborations; Conflict (Psychology); Copy Number Polymorphism; DNA; DNA Repair; DNA Repair Pathway; DNA Sequence Rearrangement; DNA biosynthesis; DNA replication fork; DNA sequencing; DNA-Directed DNA Polymerase; Defect; Development; Disease; Drug resistance; Educational workshop; Electron Microscopy; Eukaryota; Evolution; Genetic Recombination; Genome; Genome Stability; Genomic DNA; Genomic Instability; Goals; Human; International; Joints; Knowledge; Lead; Life; Link; Maintenance; Malignant Neoplasms; Metabolism; Methodology; Microscopy; Molecular Machines; Names; Neoplasm Metastasis; New Mexico; Organism; Outcome; Participant; Pathway interactions; Predisposition; Principal Investigator; Process; Prokaryotic Cells; Regulation; Repetitive Sequence; Research; Research Personnel; Resolution; Role; Scientist; Series; Shapes; Site; Techniques; Technology; Telomerase; Therapeutic Intervention; Thinking; Time; Untranslated RNA; Woman; Work; chromosome replication; clinical practice; epigenome; frontier; genome editing; genome integrity; helicase; meetings; metaplastic cell transformation; new technology; novel; particle; posters; programs; recombinational repair; reconstitution; repaired; symposium; targeted treatment; transgenerational epigenetic inheritance; tumor heterogeneity

ABSTRACT Support is requested for a Keystone Symposia conference entitled DNA Replication and Recombination, organized by Drs. John F.X. Diffley, Anja Groth and Scott Keeney. The conference will be held in Santa Fe, New Mexico from April 2-6, 2017. DNA replication and recombination are common to all cells. Errors in these processes lead to many diseases in humans, including cancer, and many fundamental questions are still unresolved. Due to recent technical advances in microscopy and other techniques, these dynamic processes can now be studied in time and space in both prokaryotes and eukaryotes. Moreover, breakthroughs in the biochemical reconstitution of processes in DNA replication and recombination repair as well as single particle electron microscopy promise to reveal new mechanisms at near-atomic resolution; and new DNA sequencing technologies make it possible to study these key processes in great details. Mechanistic similarities across the three domains of life provide new basic principles while differences identify potential targets for therapeutic intervention. This series has historically been one of the premiere conferences in this field and one of the very few that brings together scientists working in replication and recombination across all life forms. Because of the close relationship between DNA replication and recombination and their importance for genome stability, this conference will be held jointly with the Keystone Symposia conference on Genomic Instability and DNA Repair. Talks at the DNA Replication and Recombination conference will focus on the mechanism and regulation of these processes, with an emphasis on multiple organisms and multiple approaches. Talks in joint sessions will center on the metabolism of stalled replication forks and the importance of chromatin in replication, recombination and genome stability.

摘要 请求为题为DNA复制和扩增的Keystone专题讨论会提供支助， 由John F. X博士组织。Diffley，Anja Groth and Scott Keeney.会议将在圣达菲举行， 新墨西哥州，2017年4月2日至6日。DNA的复制和重组是所有细胞所共有的。错误在这些 过程导致人类许多疾病，包括癌症，许多基本问题仍然存在。 未解决的。由于显微镜和其他技术的最新技术进步，这些动态过程 现在可以在原核生物和真核生物中进行时间和空间的研究。此外， DNA复制和重组修复过程以及单颗粒的生化重建 电子显微镜有望揭示近原子分辨率的新机制;新的DNA测序 技术使我们有可能对这些关键过程进行更详细的研究。机械相似性 生命的三个领域提供了新的基本原则，而差异则确定了治疗的潜在目标。 干预这个系列历来是该领域的首映式之一，也是最重要的会议之一。 很少有科学家聚集在一起研究所有生命形式的复制和重组。因为 DNA复制和重组之间的密切关系及其对基因组稳定性的重要性， 这次会议将与基因组不稳定性和DNA的基石研讨会联合举行 修复.在DNA复制和纯化会议上的谈话将集中在机制和 这些过程的监管，重点是多种生物和多种方法。联合会谈 会议将集中在停滞的复制叉的代谢和染色质的重要性， 复制、重组和基因组稳定性。