Maternal-Fetal Cross Talk: Harmony vs. Conflict

母胎对话：和谐与冲突

• 批准号: 9398843
• 负责人: Jane Peterson
• 金额: $ 0.6万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-05 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9398843
• 关键词: Acute; Address; Adult; Atherosclerosis; Biological; Biology; Childhood; Chronic; Chronic Disease; Collaborations; Conflict (Psychology); Data; Development; Diabetes Mellitus; Diagnosis; Discipline; Disease; Economics; Educational workshop; Equilibrium; Face; Fetal Development; Fetal Growth; Fetal Growth Retardation; Fetus; Future; Generations; Genomics; Genotype; Geography; Goals; Growth; Health; Immune; Immune system; Individual; Inequality; Infection; Knowledge; Lead; Life; Maternal Health; Mentors; Metabolic; Methodology; Mothers; Obesity; Outcome; Physiological; Placentation; Plant Roots; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Premature Birth; Prevalence; Research; Research Personnel; Risk; Science; Scientist; Shapes; Spontaneous abortion; System; Washington; Work; adverse pregnancy outcome; clinical practice; cohort; design; disorder prevention; epigenomics; fetal; imprint; improved; infancy; innovation; meetings; metabolome; microbial; microbiome; new technology; posters; pressure; prospective; reproductive; social; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Maternal-Fetal Cross Talk: Harmony vs. Conflict, organized by Drs. Jeff Murray, Louis J. Muglia and Yoel Sadovsky. The conference will be held in Washington, D.C. from October 4-8, 2017. The interactions between the mother and the fetus during the progression of normal pregnancy involve trade-offs, or even conflicts, between factors that improve maternal health and those that support fetal development and growth. These may lead to selective evolutionary pressures that differ among species, and result in intriguing differences in reproductive strategies that enhance maternal-fetal biological harmony, and mitigate conflict. Strategies to balance these pressures include imprinting, coincident with placentation. Adverse pregnancy outcomes, such as miscarriage, preterm birth, preeclampsia and intrauterine growth restriction, are heterogeneous, and gaps remain in understanding how imbalances between maternal and fetal adaptations contribute to these disorders. The goal of this meeting is to bring together investigators from diverse disciplines who investigate maternal and fetal factors that shape pregnancy outcomes by exploring how these systems work together or are at odds. The conference will aim to develop these concepts, illuminating developmental, genomic/epigenomic, immune, microbial and metabolic factors as well as consider how acute exposures during pregnancy, such as infection, shape maternal-fetal outcomes. Understanding the biology underpinning these considerations will contribute to better diagnosis, treatment and disease prevention during pregnancy.

摘要 要求为一个题为“母胎对话：和谐与和谐”的基石专题讨论会提供支助。 冲突，由杰夫·默里博士、路易斯·J·穆利亚和尤尔·萨多夫斯基组织。会议将于 2017年10月4日至8日，华盛顿，华盛顿特区。母亲和胎儿之间的相互作用， 正常妊娠的进展涉及改善孕产妇健康的因素之间的权衡，甚至冲突。 健康和那些支持胎儿发育和生长。这些可能导致选择性进化 不同物种之间的压力不同，并导致生殖策略的有趣差异， 母胎生物和谐，缓解冲突。平衡这些压力的策略包括 印记，与胎座形成一致。不良妊娠结局，如流产，早产， 先兆子痫和子宫内生长受限是异质性的，在理解如何 母体和胎儿适应性之间的不平衡导致了这些疾病。这次会议的目的是 汇集来自不同学科的调查人员，他们调查了形成胎儿畸形的母亲和胎儿因素， 通过探索这些系统如何协同工作或相互矛盾来研究妊娠结局。会议旨在 发展这些概念，阐明发育，基因组/表观基因组，免疫，微生物和代谢 因素，以及考虑如何在怀孕期间的急性暴露，如感染，形状母胎 结果。了解这些考虑的生物学基础将有助于更好的诊断， 怀孕期间的治疗和疾病预防。