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The Origins of Preadolescent Risk for Psychiatric Disorders in Early Childhood Brain Development

儿童早期大脑发育中青春期前精神疾病风险的根源

基本信息

批准号：
9383608
负责人：
JOHN Horace GILMORE
金额：
$ 76.68万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9383608
关键词：
10 year old 6 year old Address Adolescent Adult Age Amygdaloid structure Anisotropy Anterior Anxiety Area Attention Behavior Behavior assessment Behavioral Biological Markers Birth Brain Child Childhood Cognitive Development Diffusion Dorsal Early Intervention Enrollment Functional Imaging Globus Pallidus Goals Hippocampus (Brain)Human Image Individual Individual Differences Inferior Insula of Reil Intervention Knowledge Lateral Longitudinal Studies Longitudinal cohort Magnetic Resonance Imaging Medial Mental disorders Modeling National Institute of Mental Health Neurocognitive Outcome Phase Phenotype Prefrontal Cortex Reporting Research Research Domain Criteria Rest Risk Risk Behaviors School-Age Population Severity of illness Structure Structure-Activity Relationship Subgroup Surface Symptoms Testing Thalamic structure Thick age group base behavioral outcome brain abnormalities cognitive development cohort disorder risk early childhood executive function experience gray matter improved improved functioning innovation postnatal preadolescence prenatal prevent trait white matter

项目摘要

Abstract It has been hypothesized for years that most psychiatric disorders are the result of abnormal trajectories of early childhood brain development and a major priority for NIMH is to better understand how risk for psychiatric disorders unfold in childhood, to inform early intervention strategies that prevent or mitigate risk and illness severity. The UNC Early Brain Development Study is a longitudinal study that has followed children, enrolled prenatally, with imaging and developmental assessments at birth and at ages 1, 2 4, and 6 years. Children from this cohort are now reaching pre-adolescence, a period in which cognitive and behavioral abnormalities associated with psychiatric disease, including executive function, attention, and anxiety, are emerging. Very little is currently known about the relationship between brain structure and development and risk phenotypes in pre-adolescence; this represents is a major gap in our knowledge and a critical need for study. We propose to follow 446 children in our longitudinal cohort at ages 8 and 10 years of age. MRIs, including structural, diffusion tensor, and resting state functional imaging, will be performed. Cognitive development and behavioral development will be assessed, with a focus on the phenotypes of executive function, attention, and anxiety, consistent with RDoC constructs and important for psychiatric disorder risk. Knowledge gained in this study will improve our basic understanding of human brain development in childhood, allow us to delineate childhood predictors of risk phenotypes in late childhood, and ultimately help target periods of childhood development for early intervention. Relevance New knowledge gained in this study will provide a dramatically improved framework for understanding childhood brain development and its relationship to cognitive and behavioral outcomes in late childhood, and to risk for subsequent psychiatric disorders.

摘要