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The Development of Individual Differences in Adolescent Brain Structure and Risk

青少年大脑结构和风险的个体差异的发展

基本信息

批准号：
10206731
负责人：
JOHN Horace GILMORE
金额：
$ 76.38万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10206731
关键词：
10 year old 12 year old 16 year old 4 year old 8 year old Adolescence Adolescent Age Anxiety Attention Behavior Behavior assessment Behavioral Biological Markers Birth Brain Child Childhood Cognitive Cohort Studies Data Development Diffusion Early Intervention Early identification Enrollment Environmental Risk Factor Functional Imaging Goals Human Image Individual Individual Differences Intervention Knowledge Life Longitudinal Studies Machine Learning Magnetic Resonance Imaging Mental disorders Modeling Morphology National Institute of Mental Health Neurocognitive Outcome Pattern Phenotype Predictive Value Puberty Reporting Research Research Domain Criteria Rest Risk Severity of illness Source Structure Testing adolescent brain development behavioral outcome brain abnormalities cohort connectome disorder risk early adolescence early childhood early detection biomarkers executive function imaging biomarker improved individual variation infancy innovation postnatal period prenatal prevent sex social white matter

项目摘要

Abstract Individual differences in brain structure, including cortical morphology and the white matter connectome are associated with risk for psychiatric disorders. The first year of life is a period of rapid and dynamic structural and functional brain development and new data from our cohort suggests that a large portion of individual differences in brain structure in 10 and 12 year olds is already present in the first year or two of life. Early adolescence and puberty is the second major period of postnatal brain development, characterized by dynamic structural and functional brain maturation and reorganization, and emerging risk for psychiatric disorders, though it is not known how this period of development contributes to individual differences in brain structure and risk. The UNC Early Brain Development Study is a unique and innovative longitudinal study that has followed children, enrolled prenatally, with imaging and cognitive/behavioral assessments at birth, 1, 2, 4, 6, 8 and 10 years. 482 children from this cohort are now reaching adolescence, and we propose to follow these children at 12, 14 and 16 years of age. MRIs, including structural, diffusion tensor, and resting state functional imaging, will be performed. Cognitive and behavioral development will be assessed, with a focus on the phenotypes of executive function, attention, and anxiety, consistent with RDoC constructs important for psychiatric disorder risk. We will determine how adolescent brain development contributes to individual differences in relation to early childhood development and whether the white matter connectome is a useful early imaging biomarker. Knowledge gained in this study will improve our basic understanding of human brain development, and ultimately inform early intervention strategies that prevent or mitigate risk and illness severity. Relevance New knowledge gained in this study will provide a dramatically improved framework for understanding childhood brain development and its relationship to cognitive and behavioral outcomes in adolescence, and to risk for subsequent psychiatric disorders.

抽象的大脑结构的个体差异，包括皮质形态和白质连接组与精神疾病的风险相关。生命的第一年是一个时期快速、动态的大脑结构和功能发育以及来自我们队列的新数据表明 10 岁和 12 岁儿童大脑结构的个体差异很大一部分是在生命的第一年或第二年就已经存在。青春期早期和青春期是第二大出生后大脑发育时期，其特点是大脑结构和功能的动态变化成熟和重组，以及新出现的精神疾病风险，尽管尚不清楚这一时期的发育如何导致大脑结构和风险的个体差异。北卡罗来纳大学早期大脑发育研究是一项独特且创新的纵向研究，对产前登记的儿童进行跟踪，在出生时进行影像学和认知/行为评估， 1、2、4、6、8 和 10 年。该队列中的 482 名儿童现已进入青春期，我们建议跟踪这些 12、14 和 16 岁的儿童。 MRI，包括结构、扩散将进行张量和静息态功能成像。认知和行为将评估发展，重点是执行功能、注意力、和焦虑，与 RDoC 对精神疾病风险很重要的构建一致。我们将确定青少年大脑发育如何影响个体差异儿童早期发育以及白质连接组是否是有用的早期成像生物标志物。这项研究中获得的知识将提高我们对人脑的基本了解发展，并最终为预防或减轻风险的早期干预策略提供信息病情严重程度。关联这项研究中获得的新知识将为以下方面提供一个显着改进的框架：了解儿童大脑发育及其与认知和行为的关系青春期的结果，以及随后发生精神疾病的风险。