权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The Development of Individual Differences in Adolescent Brain Structure and Risk

青少年大脑结构和风险的个体差异的发展

基本信息

批准号：
10376251
负责人：
JOHN Horace GILMORE
金额：
$ 72.24万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10376251
关键词：
10 year old 12 year old 16 year old 4 year old 8 year old Adolescence Adolescent Age Anxiety Attention Behavior Behavior assessment Behavioral Biological Markers Birth Brain Child Childhood Cognitive Cohort Studies Data Development Diffusion Early Intervention Early identification Enrollment Environmental Risk Factor Functional Imaging Goals Human Image Individual Individual Differences Intervention Knowledge Life Longitudinal Studies Machine Learning Magnetic Resonance Imaging Mental disorders Modeling Morphology National Institute of Mental Health Neurocognitive Outcome Pattern Phenotype Predictive Value Puberty Reporting Research Research Domain Criteria Rest Risk Severity of illness Source Structure Testing adolescent brain development behavioral outcome brain abnormalities cohort connectome disorder risk early adolescence early childhood early detection biomarkers executive function imaging biomarker improved individual variation infancy innovation postnatal period prenatal prevent sex social white matter

项目摘要

Abstract Individual differences in brain structure, including cortical morphology and the white matter connectome are associated with risk for psychiatric disorders. The first year of life is a period of rapid and dynamic structural and functional brain development and new data from our cohort suggests that a large portion of individual differences in brain structure in 10 and 12 year olds is already present in the first year or two of life. Early adolescence and puberty is the second major period of postnatal brain development, characterized by dynamic structural and functional brain maturation and reorganization, and emerging risk for psychiatric disorders, though it is not known how this period of development contributes to individual differences in brain structure and risk. The UNC Early Brain Development Study is a unique and innovative longitudinal study that has followed children, enrolled prenatally, with imaging and cognitive/behavioral assessments at birth, 1, 2, 4, 6, 8 and 10 years. 482 children from this cohort are now reaching adolescence, and we propose to follow these children at 12, 14 and 16 years of age. MRIs, including structural, diffusion tensor, and resting state functional imaging, will be performed. Cognitive and behavioral development will be assessed, with a focus on the phenotypes of executive function, attention, and anxiety, consistent with RDoC constructs important for psychiatric disorder risk. We will determine how adolescent brain development contributes to individual differences in relation to early childhood development and whether the white matter connectome is a useful early imaging biomarker. Knowledge gained in this study will improve our basic understanding of human brain development, and ultimately inform early intervention strategies that prevent or mitigate risk and illness severity. Relevance New knowledge gained in this study will provide a dramatically improved framework for understanding childhood brain development and its relationship to cognitive and behavioral outcomes in adolescence, and to risk for subsequent psychiatric disorders.

摘要