A Wearable CO2 Removal Device for Veteran Rehabilitation from Lung Disease

用于肺病退伍军人康复的可穿戴式二氧化碳去除装置

• 批准号: 10631937
• 负责人: Joseph Allen Potkay
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10631937
• 关键词: 3-Dimensional; 3D Print; Acute; Acute respiratory failure; Adult; Affect; Animal Testing; Animals; Anticoagulants; Blood; Blood flow; Blood specimen; Carbon Dioxide; Cardiac Output; Cattle; Cessation of life; Chronic; Chronic Obstructive Pulmonary Disease; Clinical; Clinical Trials; Closure by clamp; Computer Models; Computer-Aided Design; Data; Destinations; Device Designs; Device Removal; Devices; Drops; Excision; Exhalation; Experimental Designs; Fiber; Gases; General Population; Goals; Healthcare; Healthcare Systems; Heart; Human; Hypercapnia; Hypoventilation; Individual; Inhalation; Lead; Length; Liquid substance; Lung; Lung diseases; Measurement; Measures; Methods; Modeling; Monitor; Patients; Performance; Porosity; Pump; Quality of life; Rehabilitation therapy; Resistance; Sheep; System; Testing; Time; Transplantation; Venous; Ventilator; Veterans; Work; artificial lung; base; cost; design; disability; experimental study; improved; improved outcome; lung basal segment; lung pressure; novel; palliative; portability; pressure; prototype; sheep model; simulation; ventilation; wearable sensor technology

Veterans are three times more likely than the general population to develop chronic obstructive pulmonary disease (COPD), the fourth leading cause of US death. Current therapies are principally palliative, and have limited ability to restore Veterans to a sustained better quality of life. The goal of this work is to improving Veteran rehabilitation from lung disease by developing a novel artificial lung (AL) device which is optimized for CO2 removal. Recently, we developed an AL design based on concentric gating which improves overall device efficiency compared to current clinical devices. In this work, we will optimize this design to develop a CO2 removal artificial lung (CORAL) which is suitable for incorporation into a wearable system. In Aim 1, a 3D computer model of the CORAL will be built using Solidworks and blood flow simulations will be performed using the Solidworks Flow Simulation add-in. A porous media model will be used to model flow resistance due to the fiber bundle. Blood flow simulations within devices having varied fiber lengths and fiber bundle porosities will be performed. The simulations will be used to guide design of an optimized device that meets all stated specifications for the CORAL device. Once the design is chosen, components will be 3D printed and used for prototype fabrication. In Aim 2, CORAL devices will be fabricated and bench tested to experimentally determine pressure drop and gas exchange performance. In Aim 3, CORAL devices which meet gas exchange and pressure specification will be tested using an acute sheep model of hypercapnia. The successful completion of these aims will lead to a Merit Review application that will focus on the long-term implementation of the developed CO2 removal device. These studies will include chronic sheep experimentation and incorporation into an automated, wearable system, and will provide the information necessary to plan human clinical trials.

退伍军人患慢性阻塞性肺疾病的可能性是普通人群的三倍。 肺疾病（COPD），美国死亡的第四大原因。目前的治疗方法是 主要是姑息性的，而且恢复退伍军人的能力有限， 生活这项工作的目标是改善退伍军人康复从肺部疾病的发展 一种新型的人工肺（AL）装置，该装置针对CO2去除进行了优化。最近，我们开发了一种 与同心门控相比，基于同心门控的AL设计提高了整体器件效率 目前的临床设备。在这项工作中，我们将优化这一设计，以开发一种CO2去除人工 肺（CORAL），其适合于结合到可穿戴系统中。在Aim 1中，一台3D计算机 将使用Solidworks构建CORAL模型，并进行血流模拟 使用Solidworks Flow Simulation插件。多孔介质模型将用于模拟流动 由于纤维束的阻力。具有不同纤维的装置内的血流模拟 长度和纤维束孔隙率。模拟结果将用于指导设计 符合CORAL器械所有规定质量标准的优化器械。一旦设计 选择后，组件将被3D打印并用于原型制造。在目标2中，珊瑚 将制造装置并进行台架测试，以通过实验确定压降和气体 交换性能。在目标3中，CORAL器械满足气体交换和压力 将使用高碳酸血症的急性绵羊模型测试质量标准。成功 完成这些目标将导致一个功绩审查申请，将侧重于长期 实施所开发的CO2去除装置。这些研究将包括慢性羊 实验和纳入自动化，可穿戴系统，并将提供 计划人体临床试验所需的信息。