A Wearable CO2 Removal Device for Veteran Rehabilitation from Lung Disease

退伍军人患慢性阻塞性疾病的可能性是普通人的三倍 肺部疾病(COPD)，美国第四大死亡原因。目前的治疗方法是 主要是姑息治疗，使退伍军人恢复到持续更好的质量的能力有限 生活。这项工作的目标是改善退伍军人肺部疾病的康复 一种新的人工肺(AL)装置，它优化了二氧化碳的去除。最近，我们开发了一种 基于同心浇注的AL设计，与传统设计相比，提高了整体器件效率 目前的临床设备。在这项工作中，我们将对这一设计进行优化，以开发一种脱除二氧化碳的人工 肺(珊瑚)，适合纳入可穿戴系统。在《目标1》中，一台3D计算机 将使用SolidWorks建立珊瑚模型，并进行血液流动模拟 使用Solidworks流动模拟附加模块。将使用多孔介质模型来模拟流动。 由纤维束引起的阻力。具有不同纤维的设备内的血液流动模拟 将进行长度和纤维束开孔术。这些模拟将用于指导设计 一种优化的设备，满足所有规定的珊瑚设备规格。一旦设计完成， 被选中后，零部件将被3D打印并用于原型制造。《目标2》中的珊瑚 将制造设备并进行台架测试，以通过实验确定压降和气体 交换性能。在目标3中，满足气体交换和压力的珊瑚装置 规格将使用急性高碳酸血症绵羊模型进行测试。成功者 完成这些目标将产生着眼于长期目标的功绩评估申请 研制的二氧化碳脱除装置的实施。这些研究将包括慢性绵羊 试验和集成到自动化、可穿戴系统中，并将提供 计划人体临床试验所需的信息。

Veterans are three times more likely than the general population to develop chronic obstructive pulmonary disease (COPD), the fourth leading cause of US death. Current therapies are principally palliative, and have limited ability to restore Veterans to a sustained better quality of life. The goal of this work is to improving Veteran rehabilitation from lung disease by developing a novel artificial lung (AL) device which is optimized for CO2 removal. Recently, we developed an AL design based on concentric gating which improves overall device efficiency compared to current clinical devices. In this work, we will optimize this design to develop a CO2 removal artificial lung (CORAL) which is suitable for incorporation into a wearable system. In Aim 1, a 3D computer model of the CORAL will be built using Solidworks and blood flow simulations will be performed using the Solidworks Flow Simulation add-in. A porous media model will be used to model flow resistance due to the fiber bundle. Blood flow simulations within devices having varied fiber lengths and fiber bundle porosities will be performed. The simulations will be used to guide design of an optimized device that meets all stated specifications for the CORAL device. Once the design is chosen, components will be 3D printed and used for prototype fabrication. In Aim 2, CORAL devices will be fabricated and bench tested to experimentally determine pressure drop and gas exchange performance. In Aim 3, CORAL devices which meet gas exchange and pressure specification will be tested using an acute sheep model of hypercapnia. The successful completion of these aims will lead to a Merit Review application that will focus on the long-term implementation of the developed CO2 removal device. These studies will include chronic sheep experimentation and incorporation into an automated, wearable system, and will provide the information necessary to plan human clinical trials.