CSHL Eukaryotic DNA Replication & Genome Maintenance Conference

2017 CSHL真核DNA复制与基因组维护会议 项目摘要/摘要 这次会议将是关于真核DNA复制和基因组的第16次双年会议 维护和跟踪每年在冷泉港举行的非常成功的会议 自1987年9月以来的其他年份。这是唯一一次定期召开的专门关注 真核DNA复制。正因为有了这样的关注点，这次会议在今年的快速增长中发挥了重要作用。 我们对真核DNA复制过程以及它如何整合到细胞分裂周期的理解。 今年的会议将致力于与染色体复制相关的基础研究课题， 结构和功能，并将包括细胞周期和生物研究领域的重要领域 生长控制、基因组扩增和复制装置对DNA损伤的反应。作为 在过去的十年里，我们更加强调 DNA复制在DNA损伤和复制应激反应中的作用，以及细胞所采用的最小化策略 DNA复制对基因组完整性的威胁。DNA复制和DNA复制的快速收敛 DNA损伤反应领域使这次会议成为一次及时的会议。会议的形式将确保最近的 结果是面对面交流和讨论的，这将促进进展和协作。这个 强烈鼓励青年研究人员、少数族裔和女性科学家参与。 2017年会议将包括一系列不同的主题、系统和方法，包括研究 在酵母、果蝇、非洲爪哇和非洲爪哇等生物中进行染色体复制和基因扩增 哺乳动物细胞。会议将涵盖(1)复制启动和源站点规范；(2)复制 程序、染色质和发育(3)启动复制和确保保真度的机制 复制分叉进展；(4)细胞对复制停滞和复制分叉压力的反应；(5) DNA复制与细胞周期和转录的整合；(6)对DNA损伤的反应 包括检查点和复制后DNA修复；(7)对基因组不稳定性和突变的影响 当复制被解除管制时；(8)由于DNA复制功能障碍而引起的疾病，包括癌症和 其他染色体不稳定综合征。不受控制的DNA复制是肿瘤和错误的标志 DNA复制导致基因组不稳定，而染色体复制过程是DNA复制的主要目标 化疗和放射治疗。这次会议与癌症研究的相关性，并最终与改进 治疗，怎么强调都不为过。 DNA的复制是所有(真核)生命的基本过程。本次会议将集中讨论 了解这一过程发生的机制，以及DNA复制如何对基因组做出贡献 细胞表观遗传状态的稳定和维持。这次会议的学术价值包括 让处于科学生涯各个阶段的主要研究人员有机会分享和讨论他们的最新研究成果 结果和概念。口头和海报会议中的非正式同行审查在提供快速 反馈将卓有成效地指导和加速未来的研究。本次会议还提供了充足的 学习和建立协作的机会。我们没有在时间表内安排平行会议。 因此，所有与会者都有共同的体验，而幽静的会场则最大限度地增加了 富有成效的科学交流。 大型、老牌会议通常可以产生重大影响，而这次冷泉会议 无疑推动了DNA复制研究的向前发展。这次会议的独特之处在于 特别广泛的影响是年轻科学家的积极参与，他们将特别受益于 有机会展示他们的最新想法。会议档案(可通过以下方式访问主要系列视频档案 互联网)允许与会者与无法与其同事分享会议的各个方面 参加会议，同时保护发表论文的作者提出未发表研究的权利。

2017 CSHL CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE PROJECT SUMMARY/ABSTRACT This conference will be the 16th biennial meeting on Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every other year since September 1987. It is the only regularly occurring meeting that is exclusively focused on eukaryotic DNA replication. Because of this focus, the meeting has played a major role in the rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle. This year's conference will be devoted to fundamental research topics related to chromosome duplication, structure and function, and will include important areas of biological research in the areas of cell cycle and growth control, genomic amplification, and the response of the replication apparatus to DNA damage. As the field has moved forward over the past decade, we have placed an increased emphasis on the central role of DNA replication in the DNA damage and replication stress response, and strategies used by cells to minimize threats to genomic integrity arising from DNA replication. The rapid convergence of the DNA replication and DNA damage response fields makes this a timely meeting. The format of the meeting will ensure that recent results are communicated and discussed face-to-face, which will enhance progress and collaboration. The participation of young investigators, minority, and women scientists is strongly encouraged. The 2017 meeting will include a diverse array of topics, systems, and approaches including studies of chromosomal replication and gene amplification in organisms as diverse as yeast, Drosophila, Xenopus and mammalian cells. Sessions will cover (1) Replication Initiation and Origin Site specification; (2) the Replication Program, Chromatin, and Development (3) Mechanisms that Initiate Replication and ensure fidelity of Replication Fork Progression; (4) how cells respond to Replication Stalling and Replication Fork Stress; (5) integration of DNA replication with the Cell Cycle and with Transcription; (6) the response to DNA damage including Checkpoints and Post-Replication DNA repair; (7) effects on Genome Instability and Mutagenesis when replication is deregulated; (8) Diseases arising from dysfunctional DNA replication, including Cancer and other Chromosome Instability syndromes. Uncontrolled DNA replication is a hallmark of tumors and errors in DNA replication lead to genomic instability, while the process of chromosome replication is a major target for chemo- and radiotherapy. The relevance of this meeting to cancer research, and ultimately to improved therapies, cannot be overemphasized. Replication of DNA is a fundamental process in all (eukaryotic) life. This meeting will focus on understanding the mechanism by which this process occurs, and how DNA replication contributes to genome stability and maintenance of the epigenetic state of a cell. The intellectual merits of this conference include the opportunity for leading investigators at all stages of their scientific careers to share and discuss their latest results and concepts. The informal peer review in oral and poster sessions is invaluable in providing rapid feedback that will fruitfully steer and accelerate future research. This conference also provides ample opportunity for learning and for building collaborations. We do not plan parallel sessions within the schedule so that all attendees share a common experience, while the secluded venue maximizes the likelihood of productive scientific exchange. Large, established conferences generally can have significant impact, and this Cold Spring meeting has undoubtedly driven forward research in DNA replication. Unique aspects of this conference that have particularly broad impact are the active participation of younger scientists who will particularly benefit from the opportunity to present their latest ideas. The conference archive (Leading strand video archive accessible by the internet) allows participants to share aspects of the conference with their colleagues who were unable to attend while protecting the right of the presenting authors to present unpublished research.