CSHL Eukaryotic DNA Replication & Genome Maintenance Conference

2017 CSHL真核DNA复制与基因组维护会议 项目总结/摘要 本次会议将是第16届真核DNA复制和基因组两年一度的会议 维护和遵循在冷泉港举行的非常成功的会议， 自1987年9月以来，这是唯一一个定期举行的会议，专门集中在 真核DNA复制由于这一重点，会议在快速增长中发挥了重要作用， 我们对真核DNA复制过程的理解以及它如何整合到细胞分裂周期中。 今年的会议将致力于与染色体复制相关的基础研究主题， 结构和功能，并将包括生物学研究的重要领域，在细胞周期和 生长控制、基因组扩增和复制装置对DNA损伤的反应。为 在过去十年中，该领域取得了进展，我们更加强调 DNA复制中的DNA损伤和复制应激反应，以及细胞所采用的策略， DNA复制对基因组完整性的威胁。DNA复制的快速融合， DNA损伤反应场使这是一个及时的会议。会议的形式将确保最近 面对面交流和讨论成果，这将促进进展和协作。的 大力鼓励年轻研究人员、少数民族和女科学家的参与。 2017年的会议将包括各种各样的主题，系统和方法，包括研究 染色体复制和基因扩增的生物体，如酵母，果蝇，非洲爪蟾和 哺乳动物细胞会议将涵盖（1）复制启动和源站点规范;（2）复制 程序、染色质和发育（3）启动复制并确保复制保真度的机制 复制叉进展;（4）细胞如何响应复制停滞和复制叉应激;（5） DNA复制与细胞周期和转录的整合;（6）对DNA损伤的反应 包括检查点和复制后DNA修复;（7）对基因组不稳定性和突变的影响 （8）由DNA复制功能障碍引起的疾病，包括癌症和 其他染色体不稳定综合征。不受控制的DNA复制是肿瘤的标志， DNA复制导致基因组的不稳定性，而染色体复制的过程是一个主要的目标， 化疗和放疗。这次会议对癌症研究的相关性，并最终改善 治疗，不能过分强调。 DNA的复制是所有（真核）生命的基本过程。本次会议将重点讨论 了解这一过程发生的机制，以及DNA复制如何有助于基因组 稳定和维持细胞的表观遗传状态。这次会议的学术价值包括： 在他们的科学生涯的各个阶段，领先的研究人员有机会分享和讨论他们的最新 结果和概念。在口头和海报会议上进行的非正式同行审查在提供快速 这些反馈将有效地引导和加速未来的研究。本次会议还提供了丰富的 学习和建立合作的机会。我们不计划在时间表内并行会议 使所有与会者分享共同的经验，而僻静的场地最大限度地提高了可能性， 富有成效的科学交流。 大型、成熟的会议通常会产生重大影响，而这次冷泉会议 无疑推动了DNA复制的研究。这次会议的独特之处在于， 特别广泛的影响是年轻科学家的积极参与，他们将特别受益于 有机会展示他们的最新想法。会议档案（领先的视频档案， 因特网）使与会者能够与无法与之交流的同事分享会议的各个方面。 出席会议，同时保护提交作者提交未发表研究的权利。

2017 CSHL CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE PROJECT SUMMARY/ABSTRACT This conference will be the 16th biennial meeting on Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every other year since September 1987. It is the only regularly occurring meeting that is exclusively focused on eukaryotic DNA replication. Because of this focus, the meeting has played a major role in the rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle. This year's conference will be devoted to fundamental research topics related to chromosome duplication, structure and function, and will include important areas of biological research in the areas of cell cycle and growth control, genomic amplification, and the response of the replication apparatus to DNA damage. As the field has moved forward over the past decade, we have placed an increased emphasis on the central role of DNA replication in the DNA damage and replication stress response, and strategies used by cells to minimize threats to genomic integrity arising from DNA replication. The rapid convergence of the DNA replication and DNA damage response fields makes this a timely meeting. The format of the meeting will ensure that recent results are communicated and discussed face-to-face, which will enhance progress and collaboration. The participation of young investigators, minority, and women scientists is strongly encouraged. The 2017 meeting will include a diverse array of topics, systems, and approaches including studies of chromosomal replication and gene amplification in organisms as diverse as yeast, Drosophila, Xenopus and mammalian cells. Sessions will cover (1) Replication Initiation and Origin Site specification; (2) the Replication Program, Chromatin, and Development (3) Mechanisms that Initiate Replication and ensure fidelity of Replication Fork Progression; (4) how cells respond to Replication Stalling and Replication Fork Stress; (5) integration of DNA replication with the Cell Cycle and with Transcription; (6) the response to DNA damage including Checkpoints and Post-Replication DNA repair; (7) effects on Genome Instability and Mutagenesis when replication is deregulated; (8) Diseases arising from dysfunctional DNA replication, including Cancer and other Chromosome Instability syndromes. Uncontrolled DNA replication is a hallmark of tumors and errors in DNA replication lead to genomic instability, while the process of chromosome replication is a major target for chemo- and radiotherapy. The relevance of this meeting to cancer research, and ultimately to improved therapies, cannot be overemphasized. Replication of DNA is a fundamental process in all (eukaryotic) life. This meeting will focus on understanding the mechanism by which this process occurs, and how DNA replication contributes to genome stability and maintenance of the epigenetic state of a cell. The intellectual merits of this conference include the opportunity for leading investigators at all stages of their scientific careers to share and discuss their latest results and concepts. The informal peer review in oral and poster sessions is invaluable in providing rapid feedback that will fruitfully steer and accelerate future research. This conference also provides ample opportunity for learning and for building collaborations. We do not plan parallel sessions within the schedule so that all attendees share a common experience, while the secluded venue maximizes the likelihood of productive scientific exchange. Large, established conferences generally can have significant impact, and this Cold Spring meeting has undoubtedly driven forward research in DNA replication. Unique aspects of this conference that have particularly broad impact are the active participation of younger scientists who will particularly benefit from the opportunity to present their latest ideas. The conference archive (Leading strand video archive accessible by the internet) allows participants to share aspects of the conference with their colleagues who were unable to attend while protecting the right of the presenting authors to present unpublished research.