ADNI Psychometrics
ADNI Psychometrics
批准号:
9236950
负责人:
Paul K Crane
金额:
$80.21万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-09-15 至 2022-03-31
关键词:
AbbreviationsAddressAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease riskAmyloidAttentionBiological MarkersClinicalClinical TrialsCognitionCognitiveCommunitiesDataDevelopmentDiagnosisDiseaseEarly identificationElderlyEnrollmentEnsureFamilyFundingGoalsGuidelinesHeterogeneityImpaired cognitionImpairmentIndividualInternationalInvestigationLanguageLeadershipLearningLife StyleLiquid substanceMeasurementMeasuresMemoryMethodsMissionModelingModernizationNational Institute on AgingNerve DegenerationNeuropsychologyPropertyPsychometricsPublicationsQuality of lifeQuestionnairesRandomized Controlled TrialsResearchResearch PersonnelRoleServicesTestingTherapeuticTranslatingVisuospatialWorkaging brainamyloid imaginganalytical methodbiomarker evaluationcerebral atrophyclinical Diagnosisclinically relevantcognitive neurosciencecognitive testingcohortcost effectivedisorder subtypeevidence based guidelinesexecutive functionhigh riskimaging biomarkerimprovedinsightmild cognitive impairmentneuroimagingneuroimaging markerpre-clinicalresponsespellingtool
中文摘要
这是对R01 AG 029672的竞争性更新,该更新应用了现代心理测量方法,
阿尔茨海默病神经成像倡议(ADNI)收集的神经心理学数据。这个竞争激烈
更新建议分析来自ADNI和澳大利亚成像,生物标志物和生活方式的数据,
老龄化(Aibl)研究使用最先进的心理测量方法来解决实质性的重要
阿尔茨海默病(AD)研究中的问题。这个项目在许多方面起到了桥梁的作用
不经常互相交谈:现代心理测量学和认知神经科学应用于
神经退行性疾病研究人员建议解决AD研究中的两个重要问题:
提高在最早阶段检测临床前疾病的能力(目标1),
AD表现中异质性的相关性(目的2)。现代心理测量学的进步
通过将临床见解转化为定量分析,
分析方法。研究人员有一个传统,传播他们的工具,以更广泛的研究
社区,并建议继续这一传统的传播目标(目标3)。支持下一个周期
该项目的资金将确保持续的科学领导力,
认知神经科学
英文摘要
This is a competitive renewal for R01 AG 029672, which applied modern psychometric methods to
neuropsychological data collected by the Alzheimer's Disease Neuroimaging Initiative (ADNI). This competitive
renewal proposes to analyze data from ADNI and from the Australian Imaging, Biomarkers, and Lifestyles of
Ageing (AIBL) study using state-of-the-art psychometric approaches to address substantively important
questions in Alzheimer's disease (AD) research. This project in many ways serves as a bridge between fields
that do not often talk with each other: modern psychometrics and cognitive neuroscience applied to
neurodegenerative conditions. The investigators propose to tackle two important problems in AD research:
improving the ability to detect preclinical disease at the earliest stages (Aim 1) and understanding the clinical
relevance of heterogeneity in the presentation of AD (Aim 2). Advances in modern psychometrics have the
potential to optimize understanding of these critical questions by translating clinical insights into quantitative
analytic approaches. The investigators have a tradition of disseminating their tools to the broader research
community and propose to continue this tradition with a dissemination aim (Aim 3). Support for the next cycle
of funding for this project will ensure continued scientific leadership bridging modern psychometrics and
cognitive neuroscience.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Cognitively Defined Alzheimer's Subgroups: Natural history, neuropathology, and life course ramifications
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批准号:10672371
-
项目类别:
-
资助金额:$76.16万
-
财政年份:2021
-
负责人:Paul K Crane
-
依托单位:
Adult Changes in Thought (ACT) Research Program
-
批准号:10404970
-
项目类别:
-
资助金额:$1076.7万
-
财政年份:2021
-
负责人:Paul K Crane
-
依托单位:
Cognitively Defined Alzheimer's Subgroups: Natural history, neuropathology, and life course ramifications
-
批准号:10404979
-
项目类别:
-
资助金额:$72.43万
-
财政年份:2021
-
负责人:Paul K Crane
-
依托单位:
Adult Changes in Thought (ACT) Research Program Core B: Clinical Core
-
批准号:10672348
-
项目类别:
-
资助金额:$339.01万
-
财政年份:2021
-
负责人:Paul K Crane
-
依托单位:
Adult Changes in Thought (ACT) Research Program Core B: Clinical Core
-
批准号:10404972
-
项目类别:
-
资助金额:$310.33万
-
财政年份:2021
-
负责人:Paul K Crane
-
依托单位:
Adult Changes in Thought (ACT) Research Program
-
批准号:10672341
-
项目类别:
-
资助金额:$1106.05万
-
财政年份:2021
-
负责人:Paul K Crane
-
依托单位:
EPAD:GRF Informationists Administrative Supplement
-
批准号:9319505
-
项目类别:
-
资助金额:$3.3万
-
财政年份:2014
-
负责人:Paul K Crane
-
依托单位:
Genetic architecture of memory and executive functioning in Alzheimer's disease
-
批准号:8630958
-
项目类别:
-
资助金额:$76.78万
-
财政年份:2014
-
负责人:Paul K Crane
-
依托单位:
Genetic architecture of memory and executive functioning in Alzheimer's disease
-
批准号:8919195
-
项目类别:
-
资助金额:$63.16万
-
财政年份:2014
-
负责人:Paul K Crane
-
依托单位:
Genetic architecture of memory and executive functioning in Alzheimer's disease
-
批准号:9297187
-
项目类别:
-
资助金额:$63.8万
-
财政年份:2014
-
负责人:Paul K Crane
-
依托单位:
Improving Cognitive Outcome Precision & Responsiveness with Modern Psychometrics
-
批准号:7907812
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项目类别:
-
资助金额:$55.72万
-
财政年份:2007
-
负责人:Paul K Crane
-
依托单位:
Improving Cognitive Outcome Precision & Responsiveness with Modern Psychometrics
-
批准号:7672282
-
项目类别:
-
资助金额:$54.18万
-
财政年份:2007
-
负责人:Paul K Crane
-
依托单位:
Improving Cognitive Outcome Precision & Responsiveness with Modern Psychometrics
-
批准号:8120681
-
项目类别:
-
资助金额:$54.1万
-
财政年份:2007
-
负责人:Paul K Crane
-
依托单位:
ADNI Psychometrics
-
批准号:9884704
-
项目类别:
-
资助金额:$83.45万
-
财政年份:2007
-
负责人:Paul K Crane
-
依托单位:
ADNI Psychometrics
-
批准号:10116233
-
项目类别:
-
资助金额:$68.19万
-
财政年份:2007
-
负责人:Paul K Crane
-
依托单位:
Improving Cognitive Outcome Precision & Responsiveness with Modern Psychometrics
-
批准号:7495129
-
项目类别:
-
资助金额:$49.28万
-
财政年份:2007
-
负责人:Paul K Crane
-
依托单位:
Improving Cognitive Outcome Precision & Responsiveness with Modern Psychometrics
-
批准号:7321166
-
项目类别:
-
资助金额:$50.61万
-
财政年份:2007
-
负责人:Paul K Crane
-
依托单位:
ADNI Psychometrics: Machine Learning to discern Natural History Aim 2 Supplement
-
批准号:9933184
-
项目类别:
-
资助金额:$28.13万
-
财政年份:2007
-
负责人:Paul K Crane
-
依托单位:
Improving Cognitive Tests with Modern Psychometrics
-
批准号:6616453
-
项目类别:
-
资助金额:$15.38万
-
财政年份:2003
-
负责人:Paul K Crane
-
依托单位:
Improving Cognitive Tests with Modern Psychometrics
-
批准号:6897153
-
项目类别:
-
资助金额:$15.06万
-
财政年份:2003
-
负责人:Paul K Crane
-
依托单位:
海外基金