ADNI Psychometrics

这是对R01 AG 029672的竞争性更新，该更新应用了现代心理测量方法， 阿尔茨海默病神经成像倡议（ADNI）收集的神经心理学数据。这个竞争激烈 更新建议分析来自ADNI和澳大利亚成像，生物标志物和生活方式的数据， 老龄化（Aibl）研究使用最先进的心理测量方法来解决实质性的重要 阿尔茨海默病（AD）研究中的问题。这个项目在许多方面起到了桥梁的作用 不经常互相交谈：现代心理测量学和认知神经科学应用于 神经退行性疾病研究人员建议解决AD研究中的两个重要问题： 提高在最早阶段检测临床前疾病的能力（目标1）， AD表现中异质性的相关性（目的2）。现代心理测量学的进步 通过将临床见解转化为定量分析， 分析方法。研究人员有一个传统，传播他们的工具，以更广泛的研究 社区，并建议继续这一传统的传播目标（目标3）。支持下一个周期 该项目的资金将确保持续的科学领导力， 认知神经科学

This is a competitive renewal for R01 AG 029672, which applied modern psychometric methods to neuropsychological data collected by the Alzheimer's Disease Neuroimaging Initiative (ADNI). This competitive renewal proposes to analyze data from ADNI and from the Australian Imaging, Biomarkers, and Lifestyles of Ageing (AIBL) study using state-of-the-art psychometric approaches to address substantively important questions in Alzheimer's disease (AD) research. This project in many ways serves as a bridge between fields that do not often talk with each other: modern psychometrics and cognitive neuroscience applied to neurodegenerative conditions. The investigators propose to tackle two important problems in AD research: improving the ability to detect preclinical disease at the earliest stages (Aim 1) and understanding the clinical relevance of heterogeneity in the presentation of AD (Aim 2). Advances in modern psychometrics have the potential to optimize understanding of these critical questions by translating clinical insights into quantitative analytic approaches. The investigators have a tradition of disseminating their tools to the broader research community and propose to continue this tradition with a dissemination aim (Aim 3). Support for the next cycle of funding for this project will ensure continued scientific leadership bridging modern psychometrics and cognitive neuroscience.