Adult Changes in Thought (ACT) Research Program

成人思想变化 (ACT) 研究计划

• 批准号: 10672341
• 负责人: Paul K Crane
• 金额: $ 1106.05万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10672341
• 关键词: Accelerometer; Adopted; Adult; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Anti-Cholinergics; Antihypertensive Agents; Autopsy; Behavioral Sciences; Biological Assay; Biological Markers; Biology; Brain; Caregivers; Caring; Cause of Death; Cells; Cholinergic Agents; Clinical; Clinical Data; Clinical Research; Cognition; Cognitive; Cognitive aging; Cohort Studies; Communities; Complex; Conceptions; Consent; Country; Data; Data Set; Dementia; Development; Devices; Diabetes Mellitus; Diagnosis; Discipline; Disease; Ecology; Economics; Elderly; Enrollment; Ethnic Origin; Etiology; Exercise; Family; Foundations; Fright; Funding; Future; Glucose; Goals; Grant; Hour; Human; Image; Impaired cognition; Incidence; Individual; Influentials; Intervention; Investigation; Investments; Learning; Lewy Body Dementia; Life; Life Cycle Stages; MRI Scans; Measures; Mentorship; Methods; Modernization; Movement; National Institute on Aging; Nerve Degeneration; Neurobehavioral Manifestations; Neurons; Outcome; Participant; Persons; Pharmaceutical Preparations; Pharmacoepidemiology; Phenotype; Physical Function; Physical Performance; Physical activity; Policies; Positioning Attribute; Prevalence; Prevention; Process; Prospective Studies; Prospective, cohort study; Race; Recording of previous events; Records; Reproducibility; Research; Research Personnel; Resources; Risk; Risk Factors; Sample Size; Science; Scientist; Senile Plaques; Series; Specimen; Subgroup; System; Toxic effect; Visit; Work; age related; aging brain; clinical care; clinical diagnosis; cognitive function; cognitive performance; cohort; data resource; data sharing; density; design; disorder subtype; epidemiology study; ethnic diversity; follow-up; health care delivery; high risk; human old age (65+); improved; indexing; interoperability; neural; neuroimaging; neuropathology; participant enrollment; physical conditioning; preservation; prevent; programs; prospective; recruit; resilience; resilience factor; sedentary lifestyle; sleep pattern; socioeconomic diversity; stem cells; tissue resource; tool; web site

The Adult Changes in Thought (ACT) U19 Program will expand, modernize, and improve ACT's prospective cohort study to achieve advances in scientific understanding of older adults in general and dementia and Alzheimer's disease in particular. ACT is set in a healthcare delivery system. The study team identifies incident cases of dementia and Alzheimer's disease and follows consenting participants to autopsy. The Program will transform the current ACT U01 to a U19, which envisions complex multi-component programs that will have a powerful influence on the field. The Program's overarching goal is to identify risk factors across the life course that provide potential intervention targets for preserving cognition and preventing Alzheimer's disease and related dementias (ADRD). The Overall Specific Aims are: Aim 1. Expand ACT cohort enrollment and modernize and improve follow-up with emphasis on increasing racial/ethnic diversity and deep phenotyping of life course risk factors, cognitive and physical functioning, and outcomes including neuroimaging and neuropathology based ADRD outcomes. The Cores will expand cohort enrollment from 2,000 to 3,000. The study will invest in six Cores: A, Administrative; B, Clinical; C, Life Course; D, Neuropathology; E, Neuroimaging; F, Data and Analysis. These Cores will work together to further enhance the value of ACT's resources, enabling the ACT study to continue to be the foundation for an extraordinary array of science. To date, ACT has achieved a completeness of follow-up index of 94.5% and has observed 56,140 person-years of follow-up. ACT has identified >1,300 incident dementia cases and >1,000 incident Alzheimer's cases. The study has completed >850 autopsies and will surpass 1,100 autopsies this cycle. Additionally, 1,077 ACT participants had one MRI scan, and 540 have had ≥2, with funding in place for hundreds more. Aim 2. Support key Projects studying the spectrum of healthy functioning to ADRD in older adults. The three Projects center around 24-hour cycle physical activity, sedentary behavior, and sleep patterns in old age (Project 1), the implications of cognitively defined Alzheimer's disease subgroups (Project 2), and mechanisms underlying neural protection and toxicity of strong anticholinergic drugs and antihypertensive drugs (Project 3). Aim 3. Expand and improve ACT's dissemination of exceptional resources to the research community guided by NIA's adopted FAIR (Findable, Accessible, Interoperable, and Reproducible) principles. ACT has proven to be an exceptional resource to the research community, providing data and specimens to research colleagues locally, across the country, and around the world, and provides mentorship to junior investigators. We will continue to enhance our data sharing capabilities in this U19 Program.

在思想（ACT）U19计划的成人变化将扩大，现代化，并提高ACT的前景 进行队列研究，以提高对老年人和痴呆症的科学认识， 尤其是老年痴呆症。ACT设置在医疗保健提供系统中。研究小组确定了 痴呆症和阿尔茨海默病的病例，并遵循同意的参与者进行尸检。该计划将 将当前的ACT U 01转换为U19，它设想了复杂的多组件程序， 在球场上的强大影响力。该计划的首要目标是确定整个生命过程中的风险因素 为保护认知和预防阿尔茨海默病提供了潜在的干预目标， 相关性痴呆（ADRD）具体目标是：目标1。扩大ACT队列入学人数， 现代化和改进后续行动，重点是增加种族/族裔多样性和深入的表型分析， 生命过程风险因素、认知和身体功能以及包括神经影像学和 基于神经病理学的ADRD结局。核心小组将把队列入学人数从2,000人扩大到3000人。的 研究将投资于六个核心：A，管理; B，临床; C，生命过程; D，神经病理学; E， 神经影像学; F，数据与分析。这些核心将共同努力，进一步提高ACT的价值， 资源，使ACT研究继续成为一系列非凡科学的基础。到 截至目前，ACT的随访指数完成率为94.5%，观察到56，140人-年， 随访ACT已经确定了超过1,300例痴呆症病例和超过1,000例阿尔茨海默病病例。的 该研究已完成超过850例尸检，本周期将超过1，100例尸检。1 077 ACT 参与者接受了一次MRI扫描，540人接受了≥2次MRI扫描，并为数百人提供了资金。目标二。支持 研究老年人ADRD健康功能谱的关键项目。三个项目中心 老年人24小时周期的身体活动、久坐行为和睡眠模式（项目1）， 认知定义的阿尔茨海默病亚组（项目2）的含义，以及潜在的机制 强抗胆碱能药物和抗高血压药物的神经保护和毒性（项目3）。目标3。 扩大和改善ACT在NIA指导下向研究界传播特殊资源的情况， 采用FAIR（Findable，Interoperable，Reproducible）原则。ACT已被证明是一种 研究界的特殊资源，为当地的研究同事提供数据和标本， 在全国和世界各地，并提供指导，以初级调查员。我们将继续 增强我们在U19计划中的数据共享能力。

项目成果

Policy-Driven, Multimodal Deep Learning for Predicting Visual Fields from the Optic Disc and OCT Imaging.

• DOI: 10.1016/j.ophtha.2022.02.017
• 发表时间: 2022-07
• 期刊: OPHTHALMOLOGY
• 影响因子: 13.7
• 作者: Kihara, Yuka;Montesano, Giovanni;Chen, Andrew;Amerasinghe, Nishani;Dimitriou, Chrysostomos;Jacob, Aby;Chabi, Almira;Crabb, David P.;Lee, Aaron Y.
• 通讯作者: Lee, Aaron Y.

A Deep Learning Framework for the Detection and Quantification of Reticular Pseudodrusen and Drusen on Optical Coherence Tomography.

• DOI: 10.1167/tvst.11.12.3
• 发表时间: 2022-12-01
• 期刊: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
• 影响因子: 3
• 作者: Schwartz, Roy;Khalid, Hagar;Liakopoulos, Sandra;Ouyang, Yanling;de Vente, Coen;Gonzalez-Gonzalo, Cristina;Lee, Aaron Y.;Guymer, Robyn;Chew, Emily Y.;Egan, Catherine;Wu, Zhichao;Kumar, Himeesh;Farrington, Joseph;Mueller, Philipp L.;Sanchez, Clara I.;Tufail, Adnan
• 通讯作者: Tufail, Adnan

APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology.

APOE 功能丧失变异：与长寿相容，并与对阿尔茨海默病病理学的抵抗力相关。

• DOI: 10.1101/2023.07.20.23292771
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Chemparathy,Augustine;Guen,YannLe;Chen,Sunny;Lee,Eun-Gyung;Leong,Lesley;Gorzynski,John;Xu,Guangxue;Belloy,Michael;Kasireddy,Nandita;Tauber,AndrésPeña;Williams,Kennedy;Stewart,Ilaria;Wingo,Thomas;Lah,James;Jayadev,Suman;Hale
• 通讯作者: Hale

Comparison of brain imaging and physical health between research and clinical neuroimaging cohorts of ageing.

衰老研究和临床神经影像队列之间的脑成像和身体健康的比较。

• DOI: 10.1093/bjr/tqae004
• 发表时间: 2024
• 期刊: The British journal of radiology
• 作者: Mossa-Basha,Mahmud;Andre,JalalB;Yuh,Esther;Hunt,David;LaPiana,Nina;Howlett,Bradley;Krakauer,Chloe;Crane,Paul;Nelson,Jennifer;DeZelar,Margaret;Meyers,Kelly;Larson,Eric;Ralston,James;MacDonald,ChristineL
• 通讯作者: MacDonald,ChristineL

Deep Metagenomic Sequencing for Endophthalmitis Pathogen Detection Using a Nanopore Platform.

• DOI: 10.1016/j.ajo.2022.05.022
• 发表时间: 2022-10
• 期刊: AMERICAN JOURNAL OF OPHTHALMOLOGY
• 影响因子: 4.2
• 作者: Low, Liying;Nakamichi, Kenji;Akileswaran, Lakshmi;Lee, Cecilia S.;Lee, Aaron Y.;Moussa, George;Murray, Philip, I;Wallace, Graham R.;Van Gelder, Russell N.;Rauz, Saaeha
• 通讯作者: Rauz, Saaeha