Adult Changes in Thought (ACT) Research Program
成人思想变化 (ACT) 研究计划
基本信息
- 批准号:10404970
- 负责人:
- 金额:$ 1076.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-15 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerometerAdoptedAdultAffectAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease caregiverAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmericanAnti-CholinergicsAntihypertensive AgentsAutopsyBehavioral SciencesBiological AssayBiological MarkersBiologyBrainCaringCause of DeathCellsClinicalClinical DataClinical ResearchCognitionCognitiveCognitive agingCohort StudiesCommunitiesComplexConceptionsConsentCountryDataData AnalysesData SetDementiaDevicesDiabetes MellitusDiagnosisDisciplineDiseaseEcologyEconomicsElderlyEnrollmentEtiologyExerciseFamilyFoundationsFrightFundingFutureGlucoseGoalsGrantHourHumanImageImpaired cognitionIncidenceIndividualInfluentialsInterventionInvestigationLearningLewy Body DementiaLifeLife Cycle StagesMRI ScansMeasuresMentorshipMethodsModernizationMovementNational Institute on AgingNerve DegenerationNeurobehavioral ManifestationsNeuronsOutcomeParticipantPersonsPharmaceutical PreparationsPharmacoepidemiologyPhenotypePhysical FunctionPhysical PerformancePhysical activityPoliciesPositioning AttributePrevalencePreventionProcessProspective StudiesProspective cohort studyRecording of previous eventsRecordsReproducibilityResearchResearch PersonnelResourcesRiskRisk FactorsSample SizeScienceScientistSenile PlaquesSeriesSpecimenSubgroupSystemTimeToxic effectVisitWorkage relatedaging brainbaseclinical careclinical diagnosiscognitive developmentcognitive functioncognitive performancecohortdata resourcedata sharingdensitydesigndisorder subtypeepidemiology studyethnic diversityfollow-uphealth care deliveryhigh riskhuman old age (65+)improvedindexinginteroperabilityneuroimagingneuropathologyphysical conditioningpreservationpreventprogramsprospectiveracial and ethnicracial diversityrecruitrelating to nervous systemresiliencesedentary lifestylesleep patternsocioeconomic diversitystem cellstissue resourcetoolweb site
项目摘要
The Adult Changes in Thought (ACT) U19 Program will expand, modernize, and improve ACT's prospective
cohort study to achieve advances in scientific understanding of older adults in general and dementia and
Alzheimer's disease in particular. ACT is set in a healthcare delivery system. The study team identifies incident
cases of dementia and Alzheimer's disease and follows consenting participants to autopsy. The Program will
transform the current ACT U01 to a U19, which envisions complex multi-component programs that will have a
powerful influence on the field. The Program's overarching goal is to identify risk factors across the life course
that provide potential intervention targets for preserving cognition and preventing Alzheimer's disease and
related dementias (ADRD). The Overall Specific Aims are: Aim 1. Expand ACT cohort enrollment and
modernize and improve follow-up with emphasis on increasing racial/ethnic diversity and deep phenotyping of
life course risk factors, cognitive and physical functioning, and outcomes including neuroimaging and
neuropathology based ADRD outcomes. The Cores will expand cohort enrollment from 2,000 to 3,000. The
study will invest in six Cores: A, Administrative; B, Clinical; C, Life Course; D, Neuropathology; E,
Neuroimaging; F, Data and Analysis. These Cores will work together to further enhance the value of ACT's
resources, enabling the ACT study to continue to be the foundation for an extraordinary array of science. To
date, ACT has achieved a completeness of follow-up index of 94.5% and has observed 56,140 person-years of
follow-up. ACT has identified >1,300 incident dementia cases and >1,000 incident Alzheimer's cases. The
study has completed >850 autopsies and will surpass 1,100 autopsies this cycle. Additionally, 1,077 ACT
participants had one MRI scan, and 540 have had ≥2, with funding in place for hundreds more. Aim 2. Support
key Projects studying the spectrum of healthy functioning to ADRD in older adults. The three Projects center
around 24-hour cycle physical activity, sedentary behavior, and sleep patterns in old age (Project 1), the
implications of cognitively defined Alzheimer's disease subgroups (Project 2), and mechanisms underlying
neural protection and toxicity of strong anticholinergic drugs and antihypertensive drugs (Project 3). Aim 3.
Expand and improve ACT's dissemination of exceptional resources to the research community guided by NIA's
adopted FAIR (Findable, Accessible, Interoperable, and Reproducible) principles. ACT has proven to be an
exceptional resource to the research community, providing data and specimens to research colleagues locally,
across the country, and around the world, and provides mentorship to junior investigators. We will continue to
enhance our data sharing capabilities in this U19 Program.
成人思想变化(ACT) U19项目将扩展、现代化和改善ACT的前景
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul K Crane其他文献
Paul K Crane的其他文献
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{{ truncateString('Paul K Crane', 18)}}的其他基金
Cognitively Defined Alzheimer's Subgroups: Natural history, neuropathology, and life course ramifications
认知定义的阿尔茨海默病亚组:自然史、神经病理学和生命历程的影响
- 批准号:
10672371 - 财政年份:2021
- 资助金额:
$ 1076.7万 - 项目类别:
Cognitively Defined Alzheimer's Subgroups: Natural history, neuropathology, and life course ramifications
认知定义的阿尔茨海默病亚组:自然史、神经病理学和生命历程的影响
- 批准号:
10404979 - 财政年份:2021
- 资助金额:
$ 1076.7万 - 项目类别:
Adult Changes in Thought (ACT) Research Program Core B: Clinical Core
成人思想转变 (ACT) 研究计划核心 B:临床核心
- 批准号:
10672348 - 财政年份:2021
- 资助金额:
$ 1076.7万 - 项目类别:
Adult Changes in Thought (ACT) Research Program Core B: Clinical Core
成人思想转变 (ACT) 研究计划核心 B:临床核心
- 批准号:
10404972 - 财政年份:2021
- 资助金额:
$ 1076.7万 - 项目类别:
Adult Changes in Thought (ACT) Research Program
成人思想变化 (ACT) 研究计划
- 批准号:
10672341 - 财政年份:2021
- 资助金额:
$ 1076.7万 - 项目类别:
EPAD:GRF Informationists Administrative Supplement
EPAD:GRF 信息主义者行政补充
- 批准号:
9319505 - 财政年份:2014
- 资助金额:
$ 1076.7万 - 项目类别:
Genetic architecture of memory and executive functioning in Alzheimer's disease
阿尔茨海默病记忆和执行功能的遗传结构
- 批准号:
8630958 - 财政年份:2014
- 资助金额:
$ 1076.7万 - 项目类别:
Genetic architecture of memory and executive functioning in Alzheimer's disease
阿尔茨海默病记忆和执行功能的遗传结构
- 批准号:
8919195 - 财政年份:2014
- 资助金额:
$ 1076.7万 - 项目类别:
Genetic architecture of memory and executive functioning in Alzheimer's disease
阿尔茨海默病记忆和执行功能的遗传结构
- 批准号:
9297187 - 财政年份:2014
- 资助金额:
$ 1076.7万 - 项目类别:
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