Adult Changes in Thought (ACT) Research Program Core B: Clinical Core
成人思想转变 (ACT) 研究计划核心 B:临床核心
基本信息
- 批准号:10672348
- 负责人:
- 金额:$ 339.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-15 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAfrican American populationAgingAlzheimer&aposs DiseaseAreaAutopsyCalibrationCharacteristicsClinicClinic VisitsClinicalCognitionCollaborationsCommunicationCompanionsConsentCountyDataData CollectionDementiaDocumentationElderlyElementsEligibility DeterminationEnrollmentEnsureEthnic OriginFamilyGeographyGoalsHealth StatusHomeHome visitationIndividualInfrastructureInvestmentsLifeMapsMethodsMinority EnrollmentModernizationMoodsParticipantPhysical FunctionPopulations at RiskProceduresProcessQuality ControlRaceRandomizedResearchRisk FactorsSamplingSocial statusTimeUnderrepresented MinorityVisitWashingtonWorkcognitive testingcohortdata collection sitedata exchangedata sharingdata standardsdementia riskdesigndigitalethnic diversityethnic minorityfollow-upimprovedneuropathologynew technologypopulation basedprogramsracial diversityracial minorityrepositorysociodemographicssound
项目摘要
The overarching goal of the Clinical Core (Core B) is to collect data in support of the Adult Changes in Thought
(ACT) U19 Program Projects, Cores, and other studies using ACT data. The Clinical Core is responsible for
participant communication and clinic and home visit data collection from ACT study participants, and
coordinates with other Projects and Cores that include other data collection activities. One scientific challenge
the Clinical Core must address is maintaining backwards compatibility while facilitating data collection using
newer, modern methods and maintaining harmonization with companion studies. These considerations inform
all aspects of the Clinical Core’s activities. The Clinical Core’s Specific Aims are: (1) Follow and retain current
ACT participants. Refinements in the U19 Program include digital capture of extensive information on cognition
beyond that previously collected using traditional approaches. The Clinical Core will continue data collection
from home-based visits, an essential design characteristic for cohort retention. The Clinical Core will: (1a)
expand, modernize, and improve established ACT data collection to follow cognition, physical function and
function in daily life, interval changes in risk factors, health and social status and continue to identify incident
cases of dementia and Alzheimer’s disease; and (1b) support proposed Projects and Cores and ACT related
affiliated studies with targeted new data collection adding new processes to digitize and modernize cognitive
tests. (2) Enroll, follow, and retain new ACT participants. The Clinical Core plans to increase enrollment to
grow from 2,000 to 3,000 active dementia-free individuals. We will increase our geographic reach to include
more sociodemographically and racially/ethnically diverse areas in the greater Puget Sound area and will
oversample racial/ethnic minorities to achieve a goal of over 20% racial/ethnic minority enrollment. (3) Acquire
and maintain antemortem autopsy approval and enhance communication with participants and their families to
optimize postmortem intervals (PMI) for decedents who come to autopsy. The ACT study’s extensive
infrastructure has led to >850 autopsies to date from the ACT cohort. The Clinical Core will work closely with
the Neuropathology Core to use continuous quality improvement (CQI) approaches to maximize the proportion
of consenting decedents who receive a rapid autopsy. (4) Coordinate with the Administrative and Data and
Analysis Cores to ensure state-of-the-art quality control and data documentation of all data collected by the
Clinical Core. The ACT Clinical Core builds on a quarter century of data collection from a population-based
cohort of older adults and will expand, modernize and improve ACT data collection, provide outstanding
support of Projects, Cores, and affiliated studies and those receiving ACT data through extensive data sharing
infrastructure and have a larger and more sociodemographic and racially/ethnically diverse population base.
With this U19 expansion, the Clinical Core can substantially increase ACT’s contributions to scientific
understanding of aging, dementia and Alzheimer’s disease.
临床核心(核心 B)的总体目标是收集数据以支持成人思想转变
(ACT) U19 计划项目、核心和其他使用 ACT 数据的研究。临床核心负责
ACT 研究参与者的参与者沟通以及诊所和家访数据收集,以及
与包括其他数据收集活动的其他项目和核心进行协调。一项科学挑战
临床核心必须解决的是保持向后兼容性,同时促进数据收集
更新、现代的方法并与同伴研究保持协调。这些考虑因素告知
临床核心活动的各个方面。临床核心的具体目标是: (1) 遵循并保留当前的
ACT 参与者。 U19 计划的改进包括以数字方式捕获大量认知信息
超出了以前使用传统方法收集的数据。临床核心将继续收集数据
来自家庭访问,这是队列保留的一个重要设计特征。临床核心将:(1a)
扩展、现代化和改进现有的 ACT 数据收集,以跟踪认知、身体功能和
日常生活功能、危险因素、健康和社会状况的间隔变化,并持续识别事件
痴呆症和阿尔茨海默病病例; (1b) 支持拟议的项目和核心以及 ACT 相关项目
附属研究有针对性地收集新数据,添加新流程以实现认知数字化和现代化
测试。 (2) 注册、关注和保留新的 ACT 参与者。临床核心计划增加注册人数
活跃的无痴呆症患者从 2,000 人增加到 3,000 人。我们将扩大我们的地理覆盖范围,包括
大普吉特海湾地区的社会人口和种族/民族更加多样化,并将
对少数种族/族裔进行过度抽样,以实现少数族裔/族裔入学率超过 20% 的目标。 (3) 获取
维持生前尸检批准并加强与参与者及其家属的沟通,
优化前来尸检的死者的尸检间隔 (PMI)。 ACT 研究内容广泛
迄今为止,基础设施已对 ACT 队列进行了超过 850 例尸检。临床核心将与
神经病理学核心使用持续质量改进(CQI)方法来最大化比例
同意接受快速尸检的死者。 (4) 与行政和数据协调
分析核心确保对收集的所有数据进行最先进的质量控制和数据记录
临床核心。 ACT 临床核心建立在四分之一个世纪的基于人群的数据收集基础上
老年人群,并将扩大、现代化和改进 ACT 数据收集,提供杰出的
支持项目、核心和附属研究以及通过广泛的数据共享接收 ACT 数据的研究
基础设施,并拥有更大、社会人口和种族/民族多样化的人口基础。
通过 U19 扩展,临床核心可以大幅增加 ACT 对科学的贡献
了解衰老、痴呆和阿尔茨海默病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul K Crane其他文献
Paul K Crane的其他文献
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{{ truncateString('Paul K Crane', 18)}}的其他基金
Cognitively Defined Alzheimer's Subgroups: Natural history, neuropathology, and life course ramifications
认知定义的阿尔茨海默病亚组:自然史、神经病理学和生命历程的影响
- 批准号:
10672371 - 财政年份:2021
- 资助金额:
$ 339.01万 - 项目类别:
Adult Changes in Thought (ACT) Research Program
成人思想变化 (ACT) 研究计划
- 批准号:
10404970 - 财政年份:2021
- 资助金额:
$ 339.01万 - 项目类别:
Cognitively Defined Alzheimer's Subgroups: Natural history, neuropathology, and life course ramifications
认知定义的阿尔茨海默病亚组:自然史、神经病理学和生命历程的影响
- 批准号:
10404979 - 财政年份:2021
- 资助金额:
$ 339.01万 - 项目类别:
Adult Changes in Thought (ACT) Research Program Core B: Clinical Core
成人思想转变 (ACT) 研究计划核心 B:临床核心
- 批准号:
10404972 - 财政年份:2021
- 资助金额:
$ 339.01万 - 项目类别:
Adult Changes in Thought (ACT) Research Program
成人思想变化 (ACT) 研究计划
- 批准号:
10672341 - 财政年份:2021
- 资助金额:
$ 339.01万 - 项目类别:
EPAD:GRF Informationists Administrative Supplement
EPAD:GRF 信息主义者行政补充
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9319505 - 财政年份:2014
- 资助金额:
$ 339.01万 - 项目类别:
Genetic architecture of memory and executive functioning in Alzheimer's disease
阿尔茨海默病记忆和执行功能的遗传结构
- 批准号:
8630958 - 财政年份:2014
- 资助金额:
$ 339.01万 - 项目类别:
Genetic architecture of memory and executive functioning in Alzheimer's disease
阿尔茨海默病记忆和执行功能的遗传结构
- 批准号:
8919195 - 财政年份:2014
- 资助金额:
$ 339.01万 - 项目类别:
Genetic architecture of memory and executive functioning in Alzheimer's disease
阿尔茨海默病记忆和执行功能的遗传结构
- 批准号:
9297187 - 财政年份:2014
- 资助金额:
$ 339.01万 - 项目类别:
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