District of Columbia Intellectual and Developmental Disabilities Research Center

自2001年成立以来，DC-IDDRC的使命是扩大我们对潜在原因的理解 智力和发育障碍(IDD)，开发创新疗法，预防或减轻完全 这些障碍的影响，使每个儿童都能充分发挥她/他的身体和智力潜力。至 为了实现这一使命，我们为在四个国家执行完全翻译的iDDR提供了丰富的环境 合作DC学术医疗中心(儿童国家卫生系统(LEAD)，乔治·华盛顿 霍华德大学和乔治敦大学)。在这项建议中，我们的具体目标是：1) 确定原因并开发新的临床方法以预防或改善缺碘；2) 提供可访问的、最先进的、经济高效的核心设施，以实现多学科研究的凝聚力 IDDR方面的教育/培训；3)为从事iDDR的调查人员创建一个智力之家；以及4) 实施创新研究项目，解决五个iDDR主题之一(发展 早产儿脑损伤的生物标志物)。DC-IDDRC主任维托里奥·加洛博士是一位国际专家 著名神经学家，将继续领导作为组织机构的行政核心 DC-IDDRC的联系，提供管理、行政、沟通和培训，确保 合规和质量保证，指导战略规划和招聘，并促进 DC-IDDRC。科学核心为调查提供了一个综合平台和协同作用，以满足 真正的翻译iDDR。临床翻译核心(CTC)旨在为以下人员提供一站式服务 IDDR研究人员，在临床和转化性研究的每个阶段提供协助，并 优化高效、高质量实施基础研究。基因组学与蛋白质组学 核心(GPC)提供先进的基因组学和蛋白质组学技术，以及专业的统计 用于DNA、mRNA和蛋白质组学研究的分析。细胞和组织显微镜核心(CTMC)支持 研究人员使用各种先进的细胞和分子成像工具为最先进的 神经科学研究。人类和动物成像核心(HAIC)提供科学和技术支持 用于人体和动物的体内和体外全脑成像、图像处理和图像分析 学习。神经行为评估核心(NEC)提供复杂的神经行为和 神经心理学研究支持确定人类的发育和行为表型 动物。我们以假设为导向的项目名为《脆弱的早产儿小脑：阐明机制》 以及伤害的后果“。它利用了HAIC、NEC和CTC功能。通过这些组件， DC-IDDRC将加强调查人员的招聘，产生创新，并促进跨学科 共同促进新的诊断和传播的开发、实施和传播的研究 IDD患者护理的治疗进展！

Funded since 2001, the mission of the DC-IDDRC is to expand our understanding of the causes underlying intellectual and developmental disabilities (IDD), develop innovative therapies, and prevent or attenuate the full effects of these disorders, so that each child can achieve her/his full physical and intellectual potential. To realize this mission, we provide a rich environment for performing fully translational IDDR in the four collaborating DC academic medical centers (Children’s National Health System (lead), George Washington University, Howard University, and Georgetown University). In this proposal, our specific aims are: 1) To identify the causes and develop new clinical approaches for the prevention or amelioration of IDD; 2) To provide accessible, state-of-the-art and cost-effective core facilities for cohesive, multidisciplinary research and education/training in IDDR; 3) To create an intellectual home for investigators engaged in IDDR; and 4) To implement an innovative Research Project that addresses one of the five IDDR themes (Developing Biomarkers of Premature Brain Injury). The Director of the DC-IDDRC, Vittorio Gallo, PhD, is an internationally renowned neuroscientist who will continue to direct the Administrative Core that functions as the organizing nexus of the DC-IDDRC, providing management, administration, communication and training, assuring compliance and quality assurance, directing strategic planning and recruitment, and promoting the growth of the DC-IDDRC. The scientific cores provide an integrated platform and synergy for investigation as required by truly translational IDDR. The Clinical Translational Core (CTC) is designed to serve as a “one-stop-shop” for IDDR investigators, providing assistance at each stage of the clinical and translational research spectrum and optimizing the efficient, high quality implementation of fundamental research. The Genomics and Proteomics Core (GPC) provides advanced genomics and proteomics technologies, as well as specialized statistical analyses for DNA, mRNA and proteomics studies. The Cell and Tissue Microscopy Core (CTMC) supports investigators with a broad array of advanced cellular and molecular imaging tools for state-of-the-art neuroscience studies. The Human and Animal Imaging Core (HAIC) provides scientific and technical support for in vivo and ex vivo whole brain imaging, image processing, and image analysis for both human and animal studies. The Neurobehavioral Evaluation Core (NEC) provides sophisticated neurobehavioral and neuropsychological research support to define developmental and behavioral phenotypes in humans and animals. Our hypothesis-driven project is entitled “The vulnerable preterm cerebellum: Elucidating mechanisms and consequences of injury”. It utilizes the HAIC, NEC and CTC functions. Through these components, the DC-IDDRC will enhance the recruitment of investigators, generate innovation, and promote transdisciplinary research that together will facilitate the development, implementation, and dissemination of new diagnostic and therapeutic advances for the care of individuals with IDD.!