Neural Coding of 3D Object and Place Structure in Two Cortical Pathways

两条皮质通路中 3D 物体和位置结构的神经编码

• 批准号: 8997097
• 负责人: CHARLES E CONNOR
• 金额: $ 32.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8997097
• 关键词: Agnosia; Area; Biological; Blindness; Brain; Brain imaging; Cells; Characteristics; Code; Complement; Complex; Computer Simulation; Data; Data Analyses; Data Set; Diagnostic; Elements; Face; Force of Gravity; Functional Imaging; Future; Genetic Programming; Health; Homologous Gene; Human; Individual; Investigation; Lead; Maps; Measures; Medial; Memory; Modeling; Monkeys; Movement; Neurons; Pathway interactions; Patients; Perception; Positioning Attribute; Process; Prosthesis; Rehabilitation therapy; Research; Role; Sampling; Shapes; Staging; Stimulus; Stream; Stroke; Structure; Surface; Three-dimensional analysis; Vision; Visual; Visual Cortex; Visual Pathways; Visual Perception; base; brain pathway; comparative; computerized; eye center; mathematical analysis; mathematical model; novel; relating to nervous system; response; statistics; three dimensional structure; visual information; visual process; visual processing

DESCRIPTION (provided by applicant): The LONG-TERM GOAL of this project is to understand how the brain processes visual information about places-landscapes and interiors-and how that compares to brain processing of visual information about objects. We will measure object- and place-related responses of neurons in higher processing stages within two major brain pathways: (1) The ventral visual pathway is traditionally considered to be an object pathway, but our preliminary data show that it is also strongly engaged in representation of landscapes and interiors, with a dorsolateral-ventromedial gradient from object-related processing to place-related processing. (2) The recently recognized parieto-medial temporal pathway primarily processes place information and terminates in parahippocampal cortex. We will use mathematical analysis to understand how object and place information is encoded by neurons in these two pathways. We expect the results to have the following scientific impacts: 1. This first analysis of complex place shape is encoded at the level of individual neurons and groups of neurons will deepen understanding of brain mechanisms for perceiving, understanding, interacting with, and navigating through landscapes and interiors, complementing previous research at the brain imaging level. 2. Analytical comparison will elucidate how coding mechanisms are specialized for the very different structural characteristics and ecological roles of objects and places. 3. Analytical comparison of shape coding mechanisms between the ventral and parieto-medial pathways will increase understanding of how different visual functions are distributed across the brain. 4. Combined study of object and place coding will lead to future research on how these two elements combine in overall perception of visual scenes.

描述（由申请人提供）：该项目的长期目标是了解大脑如何处理有关地点景观和室内装饰的视觉信息，以及如何将有关对象的视觉信息的大脑处理进行比较。我们将测量神经元在两个主要的大脑途径内较高处理阶段中与对象和位置相关的反应：（1）传统上将腹侧视觉途径视为对象途径，但是我们的初步数据表明，它也强烈参与了景观和内部的代表性，并具有对对象级别的范围逐步处理，从而可以在对象级别进行处理。 （2）最近公认的壁层中等时间途径主要处理信息并终止于帕拉希帕胶皮质中。我们将使用数学分析来了解这两种途径中神经元如何编码对象和放置信息。我们希望结果将产生以下科学影响：1。对复杂位置形状的第一个分析是在单个神经元和神经元组的水平上编码的，将加深对大脑机制的理解，以感知，理解，与景观和内部互动和导航，并补充大脑成像水平的先前研究。 2。分析比较将阐明编码机制如何专门针对物体和地方的结构特征和生态作用。 3.腹侧和壁层中途径之间形状编码机制的分析比较将增加对不同视觉功能如何在大脑中分布的理解。 4。对物体和位置编码的结合研究将导致对这两个元素如何结合视觉场景的整体感知的未来研究。