Neural Coding of 3D Object and Place Structure in Two Cortical Pathways

两条皮质通路中 3D 物体和位置结构的神经编码

• 批准号: 8612222
• 负责人: CHARLES E CONNOR
• 金额: $ 32.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8612222
• 关键词: Agnosia; Area; Biological; Blindness; Brain; Brain imaging; Cells; Characteristics; Code; Complement; Complex; Computer Simulation; Data; Data Set; Diagnostic; Elements; Face; Force of Gravity; Functional Imaging; Future; Genetic Programming; Homologous Gene; Human; Individual; Investigation; Lead; Maps; Measures; Medial; Memory; Metric; Modeling; Monkeys; Movement; Neurons; Pathway interactions; Patients; Perception; Positioning Attribute; Process; Prosthesis; Rehabilitation therapy; Relative (related person); Research; Role; Sampling; Shapes; Staging; Stimulus; Stream; Stroke; Structure; Surface; Three-dimensional analysis; Vision; Visual; Visual Cortex; Visual Pathways; Visual Perception; base; brain pathway; comparative; computerized; eye center; mathematical analysis; mathematical model; novel; public health relevance; relating to nervous system; response; statistics; three dimensional structure; visual information; visual process; visual processing

Project summary The LONG-TERM GOAL of this project is to understand how the brain processes visual information about places-landscapes and interiors-and how that compares to brain processing of visual information about objects. We will measure object- and place-related responses of neurons in higher processing stages within two major brain pathways: (1) The ventral visual pathway is traditionally considered to be an object pathway, but our preliminary data show that it is also strongly engaged in representation of landscapes and interiors, with a dorsolateral-ventromedial gradient from object-related processing to place-related processing. (2) The recently recognized parieto-medial temporal pathway primarily processes place information and terminates in parahippocampal cortex. We will use mathematical analysis to understand how object and place information is encoded by neurons in these two pathways. We expect the results to have the following scientific impacts: 1. This first analysis of complex place shape is encoded at the level of individual neurons and groups of neurons will deepen understanding of brain mechanisms for perceiving, understanding, interacting with, and navigating through landscapes and interiors, complementing previous research at the brain imaging level. 2. Analytical comparison will elucidate how coding mechanisms are specialized for the very different structural characteristics and ecological roles of objects and places. 3. Analytical comparison of shape coding mechanisms between the ventral and parieto-medial pathways will increase understanding of how different visual functions are distributed across the brain. 4. Combined study of object and place coding will lead to future research on how these two elements combine in overall perception of visual scenes.

项目摘要 这个项目的长期目标是了解大脑如何处理视觉信息， 地点-风景和走廊-以及如何比较大脑处理的视觉信息， 对象我们将测量对象和地方相关的神经元在更高的处理阶段的反应， 两个主要的脑通路：（1）腹侧视觉通路传统上被认为是物体通路， 但我们的初步数据显示，它也强烈参与景观和室内的表现， 具有从对象相关处理到位置相关处理的背外侧-腹内侧梯度。(2)的 最近认识到，顶内侧颞叶通路主要处理位置信息，并终止于 海马旁皮质我们将使用数学分析来理解对象和位置信息是如何 由这两条通路中的神经元编码。我们预计这些结果将产生以下科学影响： 1.对复杂位置形状的第一次分析是在单个神经元和神经元组的水平上进行编码的。 神经元将加深对大脑感知，理解，互动机制的理解， 在风景和室内导航，补充了以前在大脑成像水平上的研究。 2.分析比较将阐明编码机制是如何专门为非常不同的结构 物体和场所的特征和生态作用。 3.分析比较腹侧和顶内侧通路之间的形状编码机制， 增加对不同视觉功能如何分布在大脑中的理解。 4.对物位编码的结合研究将为进一步研究这两个元素如何联合收割机提供思路 在视觉场景的整体感知中。