Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success

开发、展示和传播创新项目以实现转化成功

• 批准号: 9310443
• 负责人: Barry Coller
• 金额: $ 515.14万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-05 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9310443
• 关键词: Adopted; Back; Cessation of life; Clinical; Clinical Nursing Research; Clinical Research; Clinical Sciences; Communities; Conceptions; Data; Databases; Diagnosis; Electronic Health Record; Funding; Genome; Health; Health Policy; Hospitals; Human; Human Resources; Human Subject Research; Individual; Institutes; Knowledge; Leadership; Learning; Methods; Multicenter Studies; NCI Scholars Program; New York; Ontology; Outcome; Participant; Perception; Performance; Pharmaceutical Preparations; Phase; Phenotype; Population; Prevention; Protocols documentation; Public Health; Recruitment Activity; Research; Research Personnel; Resources; Science; Scientist; Series; Structure; Testing; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Vision; design; experience; human disease; improved; informatics infrastructure; innovation; instrument; member; novel; outreach; programs; repository; skills; success; therapeutic development; volunteer

Contact PD/PI: Coller, Barry The overall vision of the Rockefeller University Center for Clinical and Translational Science (CCTS), supported by the CTSA program, is to develop, demonstrate, and disseminate innovative programs to achieve translational success and to integrate these into a seamless “Learning Clinical Research Enterprise” that uses outcome data to drive quality improvement for the benefit of human health. To achieve this vision we will enhance our existing programs and add new ones. Specific aims: 1. To integrate our existing and new programs into a Translational Research Navigation (TRN) Program that encourages, facilitates, and insures the integrity of all human subjects research from conception to conclusion, and that will expedite our participation in the CTSA network of multi-center studies. 2. To integrate our existing and new programs into a Translational Workforce Educational Program that insures that all members of the translational workforce have the knowledge and skills required for them to perform their functions individually and as members of diverse scientific teams. 3. To integrate our existing and new programs into a From Discovery to Health- Enhancing Product Program to insure that investigators have the resources to maximize the likelihood that they can translate their novel discoveries into products that improve human health. To achieve this vision, we will: 1. Integrate our Community Engaged Navigation, Protocol Navigation, Research Participant Engagement in Protocol Priorities and Design, Basic Scientist Outreach, Mutually Aligned Community Engaged/ Mechanistic Science, Centralized Recruitment and Research Volunteer Repository, Ontology-Backed Phenotyping, and Research Participant Perception programs with a new Protocol Implementation Navigation program into an overarching TRN program under a new administrative structure with senior leadership. TRN will be supported by an integrated Informatics infrastructure adopting best practices and NIH and CTSA data standards. TRN will support both local protocols and CTSA network protocols with TRN leadership serving on the Liaisons to the Trial and Recruitment Innovation Centers. 2. Integrate our extensive current educational programs, including the KL2 Clinical Scholars program, with new educational initiatives to: prepare community clinicians to participate in research teams, enhance Clinical Research Nursing training, provide a full range of educational experiences in translating scientific discoveries into health-enhancing products, develop ontology-backed phenotyping instruments, and query large electronic health record databases to test scientific hypotheses at the population level. 3. Integrate the new Tri-Institutional Therapeutic Development Institute, which provides access to medicinal chemists and drug project management, with the CCTS Pilot program, the Rockefeller scientific resource centers, the New York Genome Center, the new Robertson Therapeutic Development Fund, the TRN program, and the CCTS Hospital to enable investigators to traverse the Valley of Death through Phase 1/2 studies. Outcome metrics will drive performance improvement throughout. Project Summary/Abstract Page 248 Contact PD/PI: Coller, Barry The Rockefeller University Center for Clinical and Translational Science is dedicated to improving human health by providing resources and personnel to support the conduct of the highest quality research to improve the prevention, diagnosis, and treatment of human disease, as well as to inform and implement public health policy. It will also produce novel methods to improve both the scientific information obtained in the studies and the way in which the research is performed.

联系PD/PI：Coller、巴里 洛克菲勒大学临床和转化科学中心（CCTS）的总体愿景， 在CTSA计划的支持下，开发、演示和传播创新计划，以实现 转化的成功，并将这些整合到一个无缝的“学习临床研究企业”， 结果数据，以推动质量改进，造福人类健康。为了实现这一愿景，我们将 加强我们现有的项目，并增加新的项目。具体目标：1.整合我们现有的和新的 转化研究导航（TRN）计划，鼓励，促进和确保 所有人类主体从概念到结论的研究的完整性，这将加快我们的研究。 参与CTSA多中心研究网络。2.将我们现有的和新的项目整合到一个 翻译劳动力教育计划，确保翻译劳动力的所有成员 具备单独履行职能以及作为 不同的科学团队。3.为了将我们现有的和新的计划整合到一个从发现到健康- 加强产品计划，以确保研究者有资源最大限度地提高 他们可以将他们的新发现转化为改善人类健康的产品。为了实现这一愿景，我们 意志：1.整合我们的社区导航、方案导航、研究参与者参与 在协议优先事项和设计，基础科学家外展，相互结盟的社区规划/机制 科学、集中招募和研究志愿者存储库、本体支持的表型分析和 研究参与者感知程序与新的协议实施导航程序， 在新的行政结构下，与高级领导人一起制定了一项总体TRN计划。将支持TRN 通过采用最佳实践和NIH和CTSA数据标准的集成信息学基础设施。TRN将 支持本地协议和CTSA网络协议，TRN领导层负责与 试验和招募创新中心。2.整合我们目前广泛的教育计划，包括 KL 2临床学者计划，新的教育举措：准备社区临床医生， 参与科研团队，加强临床科研护理培训，提供全方位的教育 将科学发现转化为健康增强产品的经验， 表型分析仪器，并查询大型电子健康记录数据库，以测试科学假设， 人口水平。3.整合新的三机构治疗发展研究所，该研究所提供 获得药物化学家和药物项目管理，与CCTS试点计划，洛克菲勒 科学资源中心，纽约基因组中心，新的罗伯逊治疗发展基金， TRN计划和CCTS医院，使调查人员能够穿越死亡谷， I/II期研究。成果指标将推动整个业绩的改善。 项目摘要/摘要第248页 联系PD/PI：Coller、巴里 洛克菲勒大学临床和转化科学中心致力于改善人类 通过提供资源和人员来支持进行最高质量的研究， 预防、诊断和治疗人类疾病，以及告知和实施公共卫生 政策它还将产生新的方法来改善研究中获得的科学信息， 进行研究的方式。