CTSA INFRASTRUCTURE FOR AIDS RESEARCH

CTSA 艾滋病研究基础设施

• 批准号: 8365037
• 负责人: Barry Coller
• 金额: $ 112.75万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365037
• 关键词: Acquired Immunodeficiency Syndrome; Health; Human; Research; Research Infrastructure; Translational Research; science education

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The goal of The Rockefeller University Center for Clinical and Translational Science is to improve human health by: 1. providing an infrastructure to conduct clinical investigation at the highest level, educational programs to train future generations of skilled and committed investigators, and novel methods of clinical investigation that can be shared with others, and 2. working closely with other CTSA institutions to set national standards so as to improve the conduct of clinical research. The 2006 Clinical and Translational Science Award transformed translational research at Rockefeller University and we propose to build on these accomplishments by: 1) enhancing our KL2 Master's degree and Certificate in Clinical and Translational Science educational programs; 2) creating a new educational program for our current K08 and K23 awardees to speed their transition to scientific independence; 3) expanding our bidirectional community engaged research with our partner institutions, integrating molecular mechanistic and population-based components, 4) completing the implementation of our integrated, customized information technology infrastructure to facilitate protocol development, review, and conduct; 5) implementing a novel real-time monitoring system to insure compliance with Good Clinical Practice; 6) enhancing our multi-disciplinary and multi-departmental Protocol Navigation program to speed protocol development, approval, and implementation, and extending it to bidirectional community engaged research; 7) expanding the application of novel nonparametric biostatistical methods to genomic and community-based investigation; 8) utilizing our new deep human phenotyping systems to aid scientific discovery and address important clinical needs; 9) utilizing a validated measure of research participants' perceptions to improve the conduct of clinical research; and 10) continuing to actively participate in the national CTSA consortium to advance the discipline of clinical and translational science for the benefit of human health. PUBLIC HEALTH RELEVANCE (provided by applicant): The Rockefeller University Center for Clinical and Translational Science is dedicated to improving human health by providing the resources and personnel to conduct the highest quality research to improve the prevention, diagnosis, and treatment of human disease. It also is producing novel methods to improve the scientific information obtained from clinical research studies and the way in which the research is performed.

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 洛克菲勒大学临床和转化科学中心的目标是通过以下方式改善人类健康：1.提供基础设施以进行最高水平的临床研究，提供教育计划以培训未来几代熟练和忠诚的研究者，并提供可与他人分享的临床研究新方法，以及2.与CTSA其他机构密切合作，制定国家标准，以改善临床研究的开展。2006年临床和转化科学奖改变了洛克菲勒大学的转化研究，我们建议通过以下方式建立这些成就：1）加强我们的KL 2硕士学位和临床和转化科学教育课程证书; 2）为我们目前的K 08和K23获奖者创建一个新的教育课程，以加快他们向科学独立的过渡; 3）与我们的合作伙伴机构一起扩大我们的双向社区参与研究，整合分子机制和基于人群的组件，4）完成我们的集成，定制信息技术基础设施的实施，以促进协议的开发，审查和执行; 5）实施新的实时监测系统，以确保符合良好的临床实践; 6）加强我们的多学科和多部门协议导航计划，以加快协议的开发，批准和实施，并将其扩展到双向社区参与研究; 7）将新型非参数生物统计方法的应用扩展到基因组和基于社区的调查; 8）利用我们新的深度人类表型分析系统来帮助科学发现并解决重要的临床需求; 9）利用研究参与者感知的有效措施来改善临床研究的开展; 10）继续积极参与国家CTSA联盟，以促进临床和转化科学学科的发展，造福人类健康。 公共卫生相关性（由申请人提供）：洛克菲勒大学临床和转化科学中心致力于通过提供资源和人员来进行最高质量的研究，以改善人类疾病的预防，诊断和治疗，从而改善人类健康。它还正在开发新的方法，以改善从临床研究中获得的科学信息和进行研究的方式。