Transforming Clinical and Translational Research and Education at Rockefeller

洛克菲勒大学医院自1963年以来一直是GCRC的获奖者，一直是 自1910年以来在洛克菲勒从事临床和转化科学研究。它曾是众多地标性建筑的所在地 该研究所在科学和临床方面做出了贡献，其中许多学员后来成为学术领袖。使用 在临床和翻译科学奖(CTSA)下可用的新资源，CTSA是。 杰出的研究人员，他们的研究跨越了基础-翻译领域，涵盖了 广泛的科学和医学学科，将整合和扩大他们的科学和教育 一个新的洛克菲勒大学临床和翻译科学中心的项目。新的中心将 通过鼓励新研究以及通过加强和集中管理来转变临床和转化性研究 以科学严谨和绝对承诺进行研究所需的支持结构 保护人体主体和参与者安全。转型中的关键要素将是：1)新的 反映美国国立卫生研究院合作协议的治理结构(U54)“援助”机制，2)创建 新的K-12临床研究学者计划提供硕士和博士学位作为补充 目前的临床学者计划，3)基础设施的增强，以促进发展和 在良好临床实践(GCP)原则下执行临床方案，包括生物医学 信息学，生物统计学。生物营养、研究护理、研究药房、参与者招募和 社区参与，以及来自临床研究(研究对象)的监管支持和监督 倡导者)支助办公室，4)开发与树突状细胞有关的创新和新的核心方法 治疗；艾滋病毒、丙型肝炎和恶性肿瘤的疫苗开发；遗传学/基因组学；评估 免疫反应和代谢表型。该中心将延续洛克菲勒专注于 科学发现、人类病理生理学和新的诊断、预防和治疗之间的接口 治疗策略。在互惠互利的情况下，它将与业界合作，以实现这些目标。这个 中心也将是国家CTSA联盟的活跃成员，为联盟提供新颖的想法 以及用于进行和评估临床和转化性研究的工具。它还将热切地采用最好的 由联盟确定的做法，并遵守联盟设定的标准。

The Rockefeller University Hospital, a GCRC awardee since 1963, has been the continuous "home" for clinical and translational science at Rockefeller since 1910. It has been the site of numerous landmark scientific and clinical contributions, and many of its trainees have gone on to become academic leaders. With the new resources available under a Clinical and Translational Science Award (CTSA), a core faculty of. distinguished investigators, whose research spans the basic-translational spectrum and encompassesa broad range of scientific and medical disciplines, will integrate and expand their scientific and educational programs in a new Rockefeller University Center for Clinical and Translational Science. The new Center will transform clinical and translational research by encouraging new studies, and by enhancing and centralizing the support structures required to conduct studies with scientific rigor and an absolute commitment to protection of human subjects and participant safety. The key elements in the transformation will be: 1)A new governance structure reflecting the NIH cooperative agreement (U54) "assistance" mechanism, 2) Creation of a new K-12 Clinical Research Scholars Program offering Masters and PhD level degrees to complement the current Clinical Scholars,Program, 3) Infrastructure enhancements to facilitate the development and conduct of clinical protocols under the principle of Good Clinical Practice (GCP), including biomedical informatics, biostatistics. bionutrition, research nursing, research pharmacy, participant recruitment and community engagement, and regulatory support and oversight from the clinical research (research subject advocate) support office, 4) Development of innovative and novel core methodologies related to dendritic cell therapy; vaccine development for HIV, hepatitis C, and malignancies; genetics/genomics; assessing the immune response; and metabolic phenotyping. The Center will continue Rockefeller's tradition of focusing on the interface between scientific discovery, human pathophysiology,and novel diagnostic, preventive and therapeutic strategies. It will partner with industry, when mutually beneficial, to achieve these goals. The Center will also be an active member of the National CTSA Consortium, offering the Consortium novel ideas and tools for conducting and evaluating clinical and translational research. It will also eagerly adopt the best practices identified by the Consortium and adhere to the standardsset by the Consortium.