Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success

开发、展示和传播创新项目以实现转化成功

• 批准号: 10349629
• 负责人: Barry Coller
• 金额: $ 367.1万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-05 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10349629
• 关键词: Address; Affect; Area; Bioethics; Biotechnology; Certification; Cessation of life; Clinical; Clinical Investigator; Clinical Nursing Research; Clinical Research; Clinical Sciences; Collaborations; Communities; Competence; Complex; Consultations; DNA sequencing; Data; Development; Diagnosis; Disease; Education; Elderly; Elements; Enrollment; Ensure; Environment; Evaluation; Formulation; Funding; Genome; Grant; Health; Health Policy; Hospitals; Human; Human Resources; Immunocompetence; Individual; Informed Consent; Infrastructure; Institutes; Institution; Knowledge; Laboratories; Leadership; Medical; Medicine; Methods; Modeling; Modification; Monitor; NCI Scholars Program; Neighborhood Health Center; New York; Nurses; Nursing Research; Outcome; Participant; Patients; Pennsylvania; Pharmacy facility; Phase; Policies; Population; Prevention; Public Health; Publications; Reporting; Reproducibility; Research; Research Design; Research Personnel; Resources; Science; Scientist; Special Population; Speed; Surveys; Time; Training; Translational Research; Translations; Universities; Vision; base; career; clinical center; clinical investigation; community engagement; design; experience; high standard; human disease; improved; innovation; monoclonal antibody production; multidisciplinary; next generation; novel; novel therapeutics; outreach; participant enrollment; participant safety; pharmacokinetics and pharmacodynamics; practice-based research network; programs; recruit; skills; success; therapeutic development; translational scientist

The overall vision of the Rockefeller University Center for Clinical and Translational Science (CCTS), supported by the CTSA program, is to develop, demonstrate, and disseminate innovative programs so as to create a model clinical research enterprise built on rigor, responsible and transparent reporting, and scientific integrity to empower translation of paradigm-breaking discoveries into better human health. Our new initiatives are designed to: 1) ensure that all of our studies set the highest standards; 2) ensure that our trainees have the team science leadership skills needed for a career in translational science; and 3) enhance scientific rigor, reproducibility, and reporting. These new areas build on the infrastructure we have developed to integrate mechanistic science into community engagement, reach out to basic scientists, speed the development of health- enhancing products, and create an optimal training environment. Our specific aims are: 1. To provide a robust infrastructure to support the conduct of clinical investigation at the highest levels of participant safety, scientific rigor, bioethics, and regulatory compliance. We will enhance our multidisciplinary Translational Research Navigation (TRN) Program and our collaboration with Clinical Directors Network (CDN), a Practice Based Research Network of Community Health Centers, to ensure that our studies meet the highest standards of design, feasibility, method validity, and transparent reporting, supporting our active participation in the CTSA Trial Innovation Network. 2. To ensure that every discovery at Rockefeller has the best chance of improving human health. We will enhance our robust pipeline of programs to support basic and clinical investigators move their paradigm-breaking discoveries into new therapeutics by leveraging the resources of the Tri-Institutional Therapeutic Development Institute, the Robertson Therapeutic Development Fund, and the University affiliated biotechnology company, Bridge Medicines .3. To educate the entire research workforce team in conducting translational research at the highest levels of participant safety, scientific rigor, bioethics, and regulatory compliance. We will further enhance the multidisciplinary team science emphasis of our educational programs for KL2 Clinical Scholars, Clinical Research Nurses, basic scientists, and community clinicians, with a focus on our new Team Science Leadership training with the CTSA Hubs at Yale, University of Pennsylvania, and Columbia. 4. To study and improve the clinical research enterprise both at Rockefeller and nationally. We will continue to use the CCTS as a laboratory for investigating the clinical research enterprise itself and methods to improve it, including obtaining outcome data from research participants, enhancing rigor, reproducibility and reporting, speeding the evaluation of novel therapeutics via in-house formulation, and creating 'super teams' of CTSA Hubs to disseminate our model of community engagement harnessing basic mechanistic studies to address community-identified health needs. We will disseminate the results throughout the CTSA consortium and scientific community by publications, presentations, and active participation in CLIC and CD2H initiatives.

洛克菲勒大学临床和转化中心的整体愿景